| Literature DB >> 29719213 |
Shuai Jiang1, Zhi Yang2, Shouyin Di3, Wei Hu2, Zhiqiang Ma3, Fulin Chen4, Yang Yang5.
Abstract
Forkhead box O (FOXO) family has recently been highlighted as important transcriptional regulators associated with many diverse carcinomas. Although redundant functionality between FOXO family members with cancer is known, regulatory ability of FOXO4 for tumorigenesis and tumor metastasis is still on the way. FOXO4 significantly regulates cell cycle, resists oxidative stress, and responses to hypoxia. FOXO4 alteration is closely linked to the progression of human cancer. In this review, we introduce the regulation of FOXO4 in physiological and pathological conditions. Particularly, the pathophysiological processes and molecular pathways regulated by FOXO4 in the development and progression of cancer are also summarized. Moreover, whether FOXO4 acts as a tumor-suppressor or pro-tumoral factor in tumors and the potential directions of future FOXO4 research are discussed. The information reviewed here may assist in the experimental design and increase the potential of FOXO4 as a therapeutic target for cancer.Entities:
Keywords: Cancer; FOXO4; Forkhead box O transcription factors; Molecular pathways; Regulatory mechanisms
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Year: 2018 PMID： 29719213 DOI： 10.1016/j.semcancer.2018.04.007
Source DB: PubMed Journal: Semin Cancer Biol ISSN： 1044-579X Impact factor: 15.707