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Literature DB >> 31529218

Current perspective on the regulation of FOXO4 and its role in disease progression.

Abstract

Forkhead box O4 (FOXO4) is a member of the FOXO family that regulates a number of genes involved in metabolism, cell cycle, apoptosis, and cellular homeostasis via transcriptional activity. It also mediates cell responses to oxidative stress and treatment with antitumor agents. The expression of FOXO4 is repressed by microRNAs in multiple cancer cells, while FOXO4 function is regulated by post-translational modifications and interaction with other proteins. The deregulation of FOXO4 is closely linked to the progression of several types of cancer, senescence, and other diseases. In this review, we present recent findings on the regulation of FOXO4 in physiological and pathological conditions and provide an overview of the complex role of FOXO4 in disease development and response to therapy.

Entities: Disease Gene

Keywords: Apoptosis; Cancer; Cell proliferation; Drug response; FOXO4

Year: 2019 PMID： 31529218 DOI： 10.1007/s00018-019-03297-w

Source DB: PubMed Journal: Cell Mol Life Sci ISSN： 1420-682X Impact factor: 9.261

121 in total

1. FOXO forkhead transcription factors induce G(2)-M checkpoint in response to oxidative stress.

Authors: Yoko Furukawa-Hibi; Kiyomi Yoshida-Araki; Tsutomu Ohta; Kyoji Ikeda; Noboru Motoyama
Journal: J Biol Chem Date: 2002-06-04 Impact factor: 5.157

2. Unspliced XBP1 Confers VSMC Homeostasis and Prevents Aortic Aneurysm Formation via FoxO4 Interaction.

Authors: Guizhen Zhao; Yi Fu; Zeyu Cai; Fang Yu; Ze Gong; Rongbo Dai; Yanhua Hu; Lingfang Zeng; Qingbo Xu; Wei Kong
Journal: Circ Res Date: 2017-10-31 Impact factor: 17.367

3. Differentiated phenotype of smooth muscle cells depends on signaling pathways through insulin-like growth factors and phosphatidylinositol 3-kinase.

Authors: K Hayashi; H Saga; Y Chimori; K Kimura; Y Yamanaka; K Sobue
Journal: J Biol Chem Date: 1998-10-30 Impact factor: 5.157

4. Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors.

Authors: Geert J P L Kops; Rene H Medema; Janet Glassford; Marieke A G Essers; Pascale F Dijkers; Paul J Coffer; Eric W-F Lam; Boudewijn M T Burgering
Journal: Mol Cell Biol Date: 2002-04 Impact factor: 4.272

5. FoxO4 regulates tumor necrosis factor alpha-directed smooth muscle cell migration by activating matrix metalloproteinase 9 gene transcription.

Authors: Hao Li; Jianping Liang; Diego H Castrillon; Ronald A DePinho; Eric N Olson; Zhi-Ping Liu
Journal: Mol Cell Biol Date: 2007-01-22 Impact factor: 4.272

6. FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1).

Authors: Armando van der Horst; Leon G J Tertoolen; Lydia M M de Vries-Smits; Roy A Frye; René H Medema; Boudewijn M T Burgering
Journal: J Biol Chem Date: 2004-05-04 Impact factor: 5.157

7. The transcription of FOXO genes is stimulated by FOXO3 and repressed by growth factors.

Authors: Ahmed Essaghir; Nicolas Dif; Catherine Y Marbehant; Paul J Coffer; Jean-Baptiste Demoulin
Journal: J Biol Chem Date: 2009-02-24 Impact factor: 5.157

8. Alteration of forkhead box O (foxo4) acetylation mediates apoptosis of podocytes in diabetes mellitus.

Authors: Peter Y Chuang; Yan Dai; Ruijie Liu; Helen He; Matthias Kretzler; Belinda Jim; Clemens D Cohen; John C He
Journal: PLoS One Date: 2011-08-17 Impact factor: 3.240

9. Deletion of hepatic FoxO1/3/4 genes in mice significantly impacts on glucose metabolism through downregulation of gluconeogenesis and upregulation of glycolysis.

Authors: Xiwen Xiong; Rongya Tao; Ronald A DePinho; X Charlie Dong
Journal: PLoS One Date: 2013-08-28 Impact factor: 3.240

10. MiR-150 promotes cellular metastasis in non-small cell lung cancer by targeting FOXO4.

Authors: Hui Li; Ruoyun Ouyang; Zi Wang; Weihua Zhou; Huiyong Chen; Yawen Jiang; Yibin Zhang; Hui Li; Mengting Liao; Weiwei Wang; Mao Ye; Zhigang Ding; Xueping Feng; Jing Liu; Bin Zhang
Journal: Sci Rep Date: 2016-12-15 Impact factor: 4.379

13 in total

Review 1. Mechanistic insights into the role of FOXO in diabetic retinopathy.

Authors: Tapan Behl; Muskan Wadhwa; Aayush Sehgal; Sukhbir Singh; Neelam Sharma; Saurabh Bhatia; Ahmed Al-Harrasi; Lotfi Aleya; Simona Bungau
Journal: Am J Transl Res Date: 2022-06-15 Impact factor: 3.940

2. Precocious Puberty in a Boy With Bilateral Leydig Cell Tumors due to a Somatic Gain-of-Function LHCGR Variant.

Authors: Chelsi Flippo; Vipula Kolli; Melissa Andrew; Seth Berger; Tricia Bhatti; Alison M Boyce; Daniel Casella; Michael T Collins; Emmanuèle Délot; Joseph Devaney; Stephen M Hewitt; Thomas Kolon; Ashwini Mallappa; Perrin C White; Deborah P Merke; Andrew Dauber
Journal: J Endocr Soc Date: 2022-08-12

3. circPDE5A regulates prostate cancer metastasis via controlling WTAP-dependent N6-methyladenisine methylation of EIF3C mRNA.

Authors: Lifeng Ding; Ruyue Wang; Qiming Zheng; Danyang Shen; Huan Wang; Zeyi Lu; Wenqin Luo; Haiyun Xie; Liangliang Ren; Minxiao Jiang; Chenhao Yu; Zhenwei Zhou; Yudong Lin; Haohua Lu; Dingwei Xue; Wenjing Su; Liqun Xia; Jochen Neuhaus; Sheng Cheng; Gonghui Li
Journal: J Exp Clin Cancer Res Date: 2022-06-02

4. Circ_0084443 Inhibits Wound Healing Via Repressing Keratinocyte Migration Through Targeting the miR-17-3p/FOXO4 Axis.

Authors: Zongliang He; Xing Xu
Journal: Biochem Genet Date: 2021-11-26 Impact factor: 2.220

5. Identification of contributing genes of Huntington's disease by machine learning.

Authors: Jack Cheng; Hsin-Ping Liu; Wei-Yong Lin; Fuu-Jen Tsai
Journal: BMC Med Genomics Date: 2020-11-23 Impact factor: 3.063

Review 6. Trash Talk: Mammalian Proteasome Regulation at the Transcriptional Level.

Authors: Hatem Elif Kamber Kaya; Senthil K Radhakrishnan
Journal: Trends Genet Date: 2020-09-25 Impact factor: 11.639

Review 7. Nicotinamide as a Foundation for Treating Neurodegenerative Disease and Metabolic Disorders.

Authors: Kenneth Maiese
Journal: Curr Neurovasc Res Date: 2021 Impact factor: 1.990

8. Functional Analysis of the Promoter Regions of Two Apoptosis-Related Genes (Bcl-2 and Cycs) and Their Regulation by Zn in Yellow Catfish.

Authors: Yang He; Tao Zhao; Fang Chen; Changchun Song; Chongchao Zhong; Zhi Luo
Journal: Int J Mol Sci Date: 2021-06-11 Impact factor: 5.923

Review 9. Elucidating the Possible Role of FoxO in Depression.

Authors: Tarapati Rana; Tapan Behl; Aayush Sehgal; Vineet Mehta; Sukhbir Singh; Neelam Sharma; Simona Bungau
Journal: Neurochem Res Date: 2021-06-01 Impact factor: 3.996

Review 10. Targeting the core of neurodegeneration: FoxO, mTOR, and SIRT1.

Authors: Kenneth Maiese
Journal: Neural Regen Res Date: 2021-03 Impact factor: 5.135