| Literature DB >> 29717110 |
Shu Wang1, Jingya Wang1, Varsha Kumar1, Jodi L Karnell1,2, Brian Naiman1, Phillip S Gross1, Saifur Rahman1, Kamelia Zerrouki1, Richard Hanna1, Christopher Morehouse3, Nicholas Holoweckyj3, Hao Liu3, Zerai Manna4, Raphaela Goldbach-Mansky5, Sarfaraz Hasni4, Richard Siegel4, Miguel Sanjuan1,6, Katie Streicher3, Michael P Cancro7, Roland Kolbeck1, Rachel Ettinger8,9.
Abstract
Although the aetiology of systemic lupus erythematosus (SLE) is unclear, dysregulated B cell responses have been implicated. Here we show that an unusual CD11chiT-bet+ B cell subset, with a unique expression profile including chemokine receptors consistent with migration to target tissues, is expanded in SLE patients, present in nephrotic kidney, enriched for autoreactive specificities and correlates with defined clinical manifestations. IL-21 can potently induce CD11chiT-bet+ B cells and promote the differentiation of these cells into Ig-secreting autoreactive plasma cells. While murine studies have identified a role for T-bet-expressing B cells in autoimmunity, this study describes and exemplifies the importance of CD11chiT-bet+ B cells in human SLE.Entities:
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Year: 2018 PMID： 29717110 PMCID： PMC5931508 DOI： 10.1038/s41467-018-03750-7
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 14.919