Rationale: A subpopulation of B cells (age-associated B cells [ABCs]) is increased in mice and humans with infections or autoimmune diseases. Because depletion of these cells might be valuable in patients with certain lung diseases, the goal was to find out if ABC-like cells were at elevated levels in such patients. Objectives: To measure ABC-like cell percentages in patients with lung granulomatous diseases. Methods: Peripheral blood and BAL cells from patients with sarcoidosis, beryllium sensitivity, or hypersensitivity pneumonitis and healthy subjects were analyzed for the percentage of B cells that were ABC-like, defined by expression of CD11c, low levels of CD21, FcRL 1-5 (Fc receptor-like protein 1-5) expression, and, in some cases, T-bet.Measurements and Main Results: ABC-like cells in blood were at low percentages in healthy subjects and higher percentages in patients with sarcoidosis as well as at high percentages among BAL cells of patients with sarcoidosis, beryllium disease, and hypersensitivity pneumonitis. Treatment of patients with sarcoidosis led to reduced percentages of ABC-like cells in blood.Conclusions: Increased levels of ABC-like cells in patients with sarcoidosis may be useful in diagnosis. The increase in percentage of ABC-like cells in patients with lung granulomatous diseases and decrease in treated patients suggests that depletion of these cells may be valuable.
Rationale: A subpopulation of B cells (age-associated B cells [ABCs]) is increased in mice and humans with infections or autoimmune diseases. Because depletion of these cells might be valuable in patients with certain lung diseases, the goal was to find out if ABC-like cells were at elevated levels in such patients. Objectives: To measure ABC-like cell percentages in patients with lung granulomatous diseases. Methods: Peripheral blood and BAL cells from patients with sarcoidosis, beryllium sensitivity, or hypersensitivity pneumonitis and healthy subjects were analyzed for the percentage of B cells that were ABC-like, defined by expression of CD11c, low levels of CD21, FcRL 1-5 (Fc receptor-like protein 1-5) expression, and, in some cases, T-bet.Measurements and Main Results:ABC-like cells in blood were at low percentages in healthy subjects and higher percentages in patients with sarcoidosis as well as at high percentages among BAL cells of patients with sarcoidosis, beryllium disease, and hypersensitivity pneumonitis. Treatment of patients with sarcoidosis led to reduced percentages of ABC-like cells in blood.Conclusions: Increased levels of ABC-like cells in patients with sarcoidosis may be useful in diagnosis. The increase in percentage of ABC-like cells in patients with lung granulomatous diseases and decrease in treated patients suggests that depletion of these cells may be valuable.
Authors: Martin S Naradikian; Arpita Myles; Daniel P Beiting; Kenneth J Roberts; Lucas Dawson; Ramin Sedaghat Herati; Bertram Bengsch; Susanne L Linderman; Erietta Stelekati; Rosanne Spolski; E John Wherry; Christopher Hunter; Scott E Hensley; Warren J Leonard; Michael P Cancro Journal: J Immunol Date: 2016-07-18 Impact factor: 5.422
Authors: Alan R Schenkel; John D Mitchell; Carlyne D Cool; Xiyuan Bai; Steve Groshong; Tilman Koelsch; Deepshikha Verma; Diane Ordway; Edward D Chan Journal: Immune Netw Date: 2022-04-11 Impact factor: 5.851
Authors: Basheer Khassawneh; Chengsong Zhu; Briana Barkes; Brian Vestal; Sarah Shrock; May Gillespie; Karin Pacheco; Kevin D Deane; Lisa A Maier; Quan-Zhen Li; Nabeel Hamzeh Journal: PLoS One Date: 2022-10-20 Impact factor: 3.752
Authors: Anna J Podolanczuk; Alyson W Wong; Shigeki Saito; Joseph A Lasky; Christopher J Ryerson; Oliver Eickelberg Journal: Am J Respir Crit Care Med Date: 2021-06-01 Impact factor: 21.405
Authors: Bashar N Alzghoul; Farah N Amer; Diana Barb; Ayoub Innabi; Mamoun T Mardini; Chen Bai; Bara Alzghoul; Tamara Al-Hakim; Noopur Singh; Mindy Buchanan; Leslie Serchuck; Diana Gomez Manjarres; Whitney W Woodmansee; Lisa A Maier; Divya C Patel Journal: ERJ Open Res Date: 2021-03-29
Authors: Laura Bauer; Lisa Jasmin Müller; Sarah M Volkers; Frederik Heinrich; Mir-Farzin Mashreghi; Clemens Ruppert; Leif E Sander; Andreas Hutloff Journal: Am J Respir Crit Care Med Date: 2021-12-15 Impact factor: 21.405