Hector M González1, Wassim Tarraf2, Priscilla Vásquez3, Ashley H Sanderlin4, Natalya I Rosenberg5, Sonia Davis6, Carlos J Rodríguez7, Linda C Gallo8, Bharat Thyagarajan9, Martha Daviglus5, Tasneem Khambaty10, Jianwen Cai6, Neil Schneiderman11. 1. Department of Neurosciences and Shiley-Marcos Alzheimer's Disease Research Center, University of California, San Diego, La Jolla, CA hectorgonzalez@ucsd.edu. 2. Institute of Gerontology and Department of Healthcare Sciences, Wayne State University, Detroit, MI. 3. Department of Neurosciences and Shiley-Marcos Alzheimer's Disease Research Center, University of California, San Diego, La Jolla, CA. 4. Section of Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC. 5. Institute for Minority Health Research, College of Medicine, University of Illinois at Chicago, Chicago, IL. 6. Collaborative Studies Coordinating Center, Department of Biostatistics, The University of North Carolina at Chapel Hill, Chapel Hill, NC. 7. Departments of Medicine and Epidemiology, Wake Forest School of Medicine, Winston-Salem, NC. 8. Institute for Behavioral and Community Health and Graduate School of Public Health, San Diego State University, San Diego, CA. 9. Department of Laboratory Medicine and Pathology, University of Minnesota Medical Center Fairview, Minneapolis, MN. 10. Department of Psychology, University of Maryland, Baltimore County, Baltimore, MD. 11. Department of Psychology, University of Miami, Coral Gables, FL.
Abstract
OBJECTIVE: Hispanics/Latinos have the highest risks for metabolic syndrome (MetS) in the U.S. and are also at increased risk for Alzheimer disease. In this study, we examined associations among neurocognitive function, MetS, and inflammation among diverse middle-aged and older Hispanics/Latinos. RESEARCH DESIGN AND METHODS: Cross-sectional data (2008-2011) from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) were analyzed to examine associations between neurocognition and MetS among diverse Hispanics/Latinos (N = 9,136; aged 45-74 years). RESULTS: MetS status was associated with lower global neurocognition, mental status, verbal learning and memory, verbal fluency, and executive function. Age significantly modified the associations between MetS and learning and memory measures. Significant associations between MetS and neurocognition were observed among middle-aged Hispanics/Latinos, and all associations remained robust to additional covariates adjustment. CONCLUSIONS: We found that MetS was associated with lower neurocognitive function, particularly in midlife. Our findings support and extend current hypotheses that midlife may be a particularly vulnerable developmental period for unhealthy neurocognitive aging.
OBJECTIVE: Hispanics/Latinos have the highest risks for metabolic syndrome (MetS) in the U.S. and are also at increased risk for Alzheimer disease. In this study, we examined associations among neurocognitive function, MetS, and inflammation among diverse middle-aged and older Hispanics/Latinos. RESEARCH DESIGN AND METHODS: Cross-sectional data (2008-2011) from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) were analyzed to examine associations between neurocognition and MetS among diverse Hispanics/Latinos (N = 9,136; aged 45-74 years). RESULTS: MetS status was associated with lower global neurocognition, mental status, verbal learning and memory, verbal fluency, and executive function. Age significantly modified the associations between MetS and learning and memory measures. Significant associations between MetS and neurocognition were observed among middle-aged Hispanics/Latinos, and all associations remained robust to additional covariates adjustment. CONCLUSIONS: We found that MetS was associated with lower neurocognitive function, particularly in midlife. Our findings support and extend current hypotheses that midlife may be a particularly vulnerable developmental period for unhealthy neurocognitive aging.
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