Literature DB >> 29712848

Rational application of macrophage-specific LXR agonists avoids the pitfalls of SREBP-induced lipogenesis.

Jason A Magida1, Ronald M Evans2,3.   

Abstract

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Year:  2018        PMID： 29712848      PMCID： PMC5960336          DOI： 10.1073/pnas.1805128115

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


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  10 in total

1.  Synthetic LXR agonist suppresses endogenous cholesterol biosynthesis and efficiently lowers plasma cholesterol.

Authors:  Thomas Pfeifer; Marlene Buchebner; Prakash G Chandak; Jay Patankar; Adelheid Kratzer; Sascha Obrowsky; Gerald N Rechberger; Rajendra S Kadam; Uday B Kompella; Gerhard M Kostner; Dagmar Kratky; Sanja Levak-Frank
Journal:  Curr Pharm Biotechnol       Date:  2011-02-01       Impact factor: 2.837

Review 2.  Liver X receptors as regulators of macrophage inflammatory and metabolic pathways.

Authors:  Noelia A-González; Antonio Castrillo
Journal:  Biochim Biophys Acta       Date:  2010-12-28

Review 3.  Heart Disease and Stroke Statistics-2017 Update: A Report From the American Heart Association.

Authors:  Emelia J Benjamin; Michael J Blaha; Stephanie E Chiuve; Mary Cushman; Sandeep R Das; Rajat Deo; Sarah D de Ferranti; James Floyd; Myriam Fornage; Cathleen Gillespie; Carmen R Isasi; Monik C Jiménez; Lori Chaffin Jordan; Suzanne E Judd; Daniel Lackland; Judith H Lichtman; Lynda Lisabeth; Simin Liu; Chris T Longenecker; Rachel H Mackey; Kunihiro Matsushita; Dariush Mozaffarian; Michael E Mussolino; Khurram Nasir; Robert W Neumar; Latha Palaniappan; Dilip K Pandey; Ravi R Thiagarajan; Mathew J Reeves; Matthew Ritchey; Carlos J Rodriguez; Gregory A Roth; Wayne D Rosamond; Comilla Sasson; Amytis Towfighi; Connie W Tsao; Melanie B Turner; Salim S Virani; Jenifer H Voeks; Joshua Z Willey; John T Wilkins; Jason Hy Wu; Heather M Alger; Sally S Wong; Paul Muntner
Journal:  Circulation       Date:  2017-01-25       Impact factor: 29.690

4.  Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses.

Authors:  Nathanael J Spann; Lana X Garmire; Jeffrey G McDonald; David S Myers; Stephen B Milne; Norihito Shibata; Donna Reichart; Jesse N Fox; Iftach Shaked; Daniel Heudobler; Christian R H Raetz; Elaine W Wang; Samuel L Kelly; M Cameron Sullards; Robert C Murphy; Alfred H Merrill; H Alex Brown; Edward A Dennis; Andrew C Li; Klaus Ley; Sotirios Tsimikas; Eoin Fahy; Shankar Subramaniam; Oswald Quehenberger; David W Russell; Christopher K Glass
Journal:  Cell       Date:  2012-09-28       Impact factor: 41.582

5.  A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis.

Authors:  A Chawla; W A Boisvert; C H Lee; B A Laffitte; Y Barak; S B Joseph; D Liao; L Nagy; P A Edwards; L K Curtiss; R M Evans; P Tontonoz
Journal:  Mol Cell       Date:  2001-01       Impact factor: 17.970

6.  Major lipids, apolipoproteins, and risk of vascular disease.

Authors:  Emanuele Di Angelantonio; Nadeem Sarwar; Philip Perry; Stephen Kaptoge; Kausik K Ray; Alexander Thompson; Angela M Wood; Sarah Lewington; Naveed Sattar; Chris J Packard; Rory Collins; Simon G Thompson; John Danesh
Journal:  JAMA       Date:  2009-11-11       Impact factor: 56.272

7.  Beneficial and Adverse Effects of an LXR Agonist on Human Lipid and Lipoprotein Metabolism and Circulating Neutrophils.

Authors:  Todd G Kirchgessner; Paul Sleph; Jacek Ostrowski; John Lupisella; Carol S Ryan; Xiaoqin Liu; Gayani Fernando; Denise Grimm; Petia Shipkova; Rongan Zhang; Ricardo Garcia; Jun Zhu; Aiqing He; Harold Malone; Richard Martin; Kamelia Behnia; Zhaoqing Wang; Yu Chen Barrett; Robert J Garmise; Long Yuan; Jane Zhang; Mohit D Gandhi; Philip Wastall; Tong Li; Shuyan Du; Lisa Salvador; Raju Mohan; Glenn H Cantor; Ellen Kick; John Lee; Robert J A Frost
Journal:  Cell Metab       Date:  2016-08-09       Impact factor: 27.287

8.  Reciprocal regulation of inflammation and lipid metabolism by liver X receptors.

Authors:  Sean B Joseph; Antonio Castrillo; Bryan A Laffitte; David J Mangelsdorf; Peter Tontonoz
Journal:  Nat Med       Date:  2003-01-13       Impact factor: 53.440

9.  Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein particles.

Authors:  Aldo Grefhorst; Baukje M Elzinga; Peter J Voshol; Torsten Plösch; Tineke Kok; Vincent W Bloks; Fjodor H van der Sluijs; Louis M Havekes; Johannes A Romijn; Henkjan J Verkade; Folkert Kuipers
Journal:  J Biol Chem       Date:  2002-07-03       Impact factor: 5.157

10.  Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages.

Authors:  Evan D Muse; Shan Yu; Chantle R Edillor; Jenhan Tao; Nathanael J Spann; Ty D Troutman; Jason S Seidman; Adam Henke; Jason T Roland; Katherine A Ozeki; Bonne M Thompson; Jeffrey G McDonald; John Bahadorani; Sotirios Tsimikas; Tamar R Grossman; Matthew S Tremblay; Christopher K Glass
Journal:  Proc Natl Acad Sci U S A       Date:  2018-04-09       Impact factor: 11.205
  10 in total
  5 in total

Review 1.  Role of Myeloid-Epithelial-Reproductive Tyrosine Kinase and Macrophage Polarization in the Progression of Atherosclerotic Lesions Associated With Nonalcoholic Fatty Liver Disease.

Authors:  Mirella Pastore; Stefania Grimaudo; Rosaria Maria Pipitone; Giulia Lori; Chiara Raggi; Salvatore Petta; Fabio Marra
Journal:  Front Pharmacol       Date:  2019-05-29       Impact factor: 5.810

2.  Encapsulation of LXR ligand by D-Nap-GFFY hydrogel enhances anti-tumorigenic actions of LXR and removes LXR-induced lipogenesis.

Authors:  Ke Feng; Chuanrui Ma; Yuxin Liu; Xiaoxiao Yang; Zhimou Yang; Yaoxia Chen; Tengyan Xu; Chengbiao Yang; Shuang Zhang; Qi Li; Zhuo Wei; Dan Zhao; Peng Zeng; Jihong Han; Jie Gao; Yuanli Chen; Yajun Duan
Journal:  Theranostics       Date:  2021-01-01       Impact factor: 11.556

Review 3.  Lipid Metabolism Disorders in the Comorbid Course of Nonalcoholic Fatty Liver Disease and Chronic Obstructive Pulmonary Disease.

Authors:  Stanislav Kotlyarov; Aleksei Bulgakov
Journal:  Cells       Date:  2021-11-01       Impact factor: 6.600

4.  Liver X Receptors Protect Dorsal Root Ganglia from Obesity-Induced Endoplasmic Reticulum Stress and Mechanical Allodynia.

Authors:  Chaitanya K Gavini; Angie L Bookout; Raiza Bonomo; Laurent Gautron; Syann Lee; Virginie Mansuy-Aubert
Journal:  Cell Rep       Date:  2018-10-09       Impact factor: 9.423

5.  Macrophage Paired Immunoglobulin-Like Receptor B Deficiency Promotes Peripheral Atherosclerosis in Apolipoprotein E-Deficient Mice.

Authors:  Wenhua Su; Liwen Liang; Liang Zhou; Yu Cao; Xiuli Zhou; Shiqi Liu; Qian Wang; Hong Zhang
Journal:  Front Cell Dev Biol       Date:  2022-03-07
  5 in total

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