Literature DB >> 2971269

The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function.

J M McCune1, R Namikawa, H Kaneshima, L D Shultz, M Lieberman, I L Weissman.   

Abstract

The study of human hematopoietic cells and the human immune system is hampered by the lack of a suitable experimental model. Experimental data are presented showing that human fetal liver hematopoietic cells, human fetal thymus, and human fetal lymph node support the differentiation of mature human T cells and B cells after engraftment into mice with genetically determined severe combined immunodeficiency. The resultant SCID-hu mice are found to have a transient wave of human CD4+ and CD8+ T cells and human IgG (immunoglobulin G) in the peripheral circulation. The functional status of the human immune system within this mouse model is not yet known.

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Year:  1988        PMID： 2971269     DOI： 10.1126/science.2971269

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  376 in total

Review 1.  Characterization of the human antiporcine immune response: a prerequisite to xenotransplantation.

Authors:  A L Bothwell
Journal:  Immunol Res       Date:  1999       Impact factor: 2.829

2.  R5 strains of human immunodeficiency virus type 1 from rapid progressors lacking X4 strains do not possess X4-type pathogenicity in human thymus.

Authors:  R D Berkowitz; A B van't Wout; N A Kootstra; M E Moreno; V D Linquist-Stepps; C Bare; C A Stoddart; H Schuitemaker; J M McCune
Journal:  J Virol       Date:  1999-09       Impact factor: 5.103

3.  Functional reconstitution of thymopoiesis after human immunodeficiency virus infection.

Authors:  S G Kitchen; S Killian; J V Giorgi; J A Zack
Journal:  J Virol       Date:  2000-03       Impact factor: 5.103

4.  Antiviral activity of 2'-deoxy-3'-oxa-4'-thiocytidine (BCH-10652) against lamivudine-resistant human immunodeficiency virus type 1 in SCID-hu Thy/Liv mice.

Authors:  C A Stoddart; M E Moreno; V D Linquist-Stepps; C Bare; M R Bogan; A Gobbi; R W Buckheit; J Bedard; R F Rando; J M McCune
Journal:  Antimicrob Agents Chemother       Date:  2000-03       Impact factor: 5.191

5.  Immunohistochemical analysis, human papillomavirus DNA detection, hormonal manipulation, and exogenous gene expression of normal and dysplastic human cervical epithelium in severe combined immunodeficiency mice.

Authors:  J A Taylor; K Tewari; S Y Liao; C C Hughes; L P Villarreal
Journal:  J Virol       Date:  1999-06       Impact factor: 5.103

6.  Induction of the chemokine stromal-derived factor-1 following DNA damage improves human stem cell function.

Authors:  T Ponomaryov; A Peled; I Petit; R S Taichman; L Habler; J Sandbank; F Arenzana-Seisdedos; A Magerus; A Caruz; N Fujii; A Nagler; M Lahav; M Szyper-Kravitz; D Zipori; T Lapidot
Journal:  J Clin Invest       Date:  2000-12       Impact factor: 14.808

Review 7.  Are natural killer cells the key to treating Epstein-Barr virus-associated lymphoproliferative disorders?

Authors:  M J Robertson
Journal:  J Clin Invest       Date:  2001-09       Impact factor: 14.808

8.  Mechanism of human immunodeficiency virus type 1 localization in CD4-negative thymocytes: differentiation from a CD4-positive precursor allows productive infection.

Authors:  S G Kitchen; C H Uittenbogaart; J A Zack
Journal:  J Virol       Date:  1997-08       Impact factor: 5.103

9.  Hematopoietic stem cell and progenitor cell mechanisms in myelodysplastic syndromes.

Authors:  Wendy W Pang; John V Pluvinage; Elizabeth A Price; Kunju Sridhar; Daniel A Arber; Peter L Greenberg; Stanley L Schrier; Christopher Y Park; Irving L Weissman
Journal:  Proc Natl Acad Sci U S A       Date:  2013-02-06       Impact factor: 11.205

Review 10.  Cancer stem cells: relevance to SCT.

Authors:  T Lin; R J Jones; W Matsui
Journal:  Bone Marrow Transplant       Date:  2009-02-23       Impact factor: 5.483
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