Literature DB >> 29712364

Expanding the Pyrimidine Diphosphosugar Repertoire: The Chemoenzymatic Synthesis of Amino- and Acetamidoglucopyranosyl Derivatives.

Jiqing Jiang1, John B Biggins1, Jon S Thorson1.   

Abstract

The exploitation of a unique thymidylyltransferase (Ep ) allows the rapid syntheses of thymidine and uridine 5'-(aminodeoxy-α-D-hexopyranosyl diphosphates), 5'-(acetamidodeoxy-α-D-hexopyranosyl diphosphates), and even 5'-(aminodideoxy-α-D-hexopyranosyl diphosphates), which are amino analogues of the products from the native reaction of Ep .
© 2001 WILEY-VCH Verlag GmbH, Weinheim, Fed. Rep. of Germany.

Entities:  

Keywords:  enzyme catalysis; glycosyl phosphate; nucleotides; synthetic methods; transferases

Year:  2001        PMID： 29712364     DOI： 10.1002/1521-3773(20010417)40:8<1502::AID-ANIE1502>3.0.CO;2-K

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  3 in total

1.  Expanding pyrimidine diphosphosugar libraries via structure-based nucleotidylyltransferase engineering.

Authors:  William A Barton; John B Biggins; Jiqing Jiang; Jon S Thorson; Dimitar B Nikolov
Journal:  Proc Natl Acad Sci U S A       Date:  2002-10-08       Impact factor: 11.205

Review 2.  Rhamnose-Containing Compounds: Biosynthesis and Applications.

Authors:  Siqiang Li; Fujia Chen; Yun Li; Lizhen Wang; Hongyan Li; Guofeng Gu; Enzhong Li
Journal:  Molecules       Date:  2022-08-20       Impact factor: 4.927

3.  Creation of the first anomeric D/L-sugar kinase by means of directed evolution.

Authors:  Dirk Hoffmeister; Jie Yang; Lesley Liu; Jon S Thorson
Journal:  Proc Natl Acad Sci U S A       Date:  2003-11-11       Impact factor: 11.205
  3 in total

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