Literature DB >> 29711102

PNA: Synthetic Polyamide Nucleic Acids with Unusual Binding Properties.

Eugen Uhlmann1, Anusch Peyman1, Gerhard Breipohl1, David W Will1.   

Abstract

The astonishing discovery that peptide nucleic acids (PNAs, B=nucleobase), in spite of their drastic structural difference to natural DNA, are better nucleic acid mimetics than many other oligonucleotides has resulted in an explosion of research into this class of compounds. The synthesis, physical properties, and biological interactions of PNAs as well as their chimeras with DNA and RNA are summarized here. © 1998 WILEY-VCH Verlag GmbH, Weinheim, Fed. Rep. of Germany.

Entities:  

Keywords:  Antisense agents; DNA recognition; Gene technology; Molecular recognition; Peptide nucleic acids

Year:  1998        PMID： 29711102     DOI： 10.1002/(SICI)1521-3773(19981102)37:20<2796::AID-ANIE2796>3.0.CO;2-K

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  15 in total

1.  A peptide nucleic acid-aminosugar conjugate targeting transactivation response element of HIV-1 RNA genome shows a high bioavailability in human cells and strongly inhibits tat-mediated transactivation of HIV-1 transcription.

Authors:  Indrajit Das; Jérôme Désiré; Dinesh Manvar; Isabelle Baussanne; Virendra N Pandey; Jean-Luc Décout
Journal:  J Med Chem       Date:  2012-06-22       Impact factor: 7.446

2.  A convenient asymmetric synthesis of a beta-amino ester with additional functionalization as a precursor for peptide nucleic acid (PNA) monomers.

Authors:  Narciso M Garrido; David Díez; Sara H Domínguez; M Rosa Sánchez; Mercedes García; Julio G Urones
Journal:  Molecules       Date:  2006-06-21       Impact factor: 4.411

3.  Triplex Hybridization of siRNA with Bifacial Glycopolymer Nucleic Acid Enables Hepatocyte-Targeted Silencing.

Authors:  Xin Xia; Zhun Zhou; Chris DeSantis; John J Rossi; Dennis Bong
Journal:  ACS Chem Biol       Date:  2019-06-11       Impact factor: 5.100

4.  Pyrrolidinyl peptide nucleic acid with α/β-peptide backbone: A conformationally constrained PNA with unusual hybridization properties.

Authors:  Chotima Vilaivan; Choladda Srisuwannaket; Cheeraporn Ananthanawat; Chaturong Suparpprom; Junji Kawakami; Yoshie Yamaguchi; Yuko Tanaka; Tirayut Vilaivan
Journal:  Artif DNA PNA XNA       Date:  2011-04

5.  Synthesis and monitored selection of nucleotide surrogates for binding T:A base pairs in homopurine-homopyrimidine DNA triple helices.

Authors:  A A Mokhir; W H Connors; C Richert
Journal:  Nucleic Acids Res       Date:  2001-09-01       Impact factor: 16.971

6.  Efficient inhibition of miR-155 function in vivo by peptide nucleic acids.

Authors:  Martin M Fabani; Cei Abreu-Goodger; Donna Williams; Paul A Lyons; Adrian G Torres; Kenneth G C Smith; Anton J Enright; Michael J Gait; Elena Vigorito
Journal:  Nucleic Acids Res       Date:  2010-03-11       Impact factor: 16.971

7.  (α,α-dimethyl)glycyl (dmg) PNAs: achiral PNA analogs that form stronger hybrids with cDNA relative to isosequential RNA.

Authors:  Aland Gourishankar; Krishna N Ganesh
Journal:  Artif DNA PNA XNA       Date:  2012 Jan-Mar

8.  Three-dimensional RNA structure of the major HIV-1 packaging signal region.

Authors:  James D Stephenson; Haitao Li; Julia C Kenyon; Martyn Symmons; Dave Klenerman; Andrew M L Lever
Journal:  Structure       Date:  2013-05-16       Impact factor: 5.006

9.  A versatile method for the preparation of conjugates of peptides with DNA/PNA/analog by employing chemo-selective click reaction in water.

Authors:  Khirud Gogoi; Meenakshi V Mane; Sunita S Kunte; Vaijayanti A Kumar
Journal:  Nucleic Acids Res       Date:  2007-11-02       Impact factor: 16.971

10.  RNA interference in mammalia cells by RNA-3'-PNA chimeras.

Authors:  Nicoletta Potenza; Loredana Moggio; Giovanna Milano; Vincenzo Salvatore; Benedetto Di Blasio; Aniello Russo; Anna Messere
Journal:  Int J Mol Sci       Date:  2008-03-12       Impact factor: 6.208
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