Francesco Signorelli1, Sapir Sela2, Loreto Gesualdo3, Sophie Chevrel4, Félix Tollet4, Cyril Pailler-Mattei5, Leonello Tacconi6, Francis Turjman7, Angelo Vacca8, David B Schul9. 1. Division of Neurosurgery, Department of Basic Medical Sciences, Neurosciences and Sense Organs, "Aldo Moro" University of Bari Medical School, Bari, Italy. Electronic address: signorelli2007@gmail.com. 2. Department of Immunology, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel. 3. Nephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, "Aldo Moro" University of Bari Medical School, Bari, Italy. 4. University "Claude Bernard Lyon 1", ISPB-Faculty of Pharmacy, Lyon, France. 5. University "Claude Bernard Lyon 1", ISPB-Faculty of Pharmacy, Lyon, France; Tribology and Systems Dynamics Laboratory, UMR-CNRS 5513, "Ecole Centrale de Lyon", Ecully, France. 6. Division of Neurosurgery, Azienda Sanitaria Universitaria Integrata di Trieste, University Hospital of Trieste, Trieste, Italy. 7. Department of Interventional Neuroradiology, Hôpital Neurologique et Neurochirurgical "P. Wertheimer", Hospices Civils de Lyon, Bron, France. 8. Unit "G. Baccelli" of Internal Medicine, Department of Biomedical Sciences and Human Oncology, "Aldo Moro" University of Bari Medical School, Bari, Italy. 9. Department of Neurosurgery, Bogenhausen Academic Teaching Hospital, Technical University of Munich, Munich, Germany.
Abstract
BACKGROUND: There seems to be a pathogenetic link between hemodynamics and inflammatory arterial wall alteration leading to the development and rupture of intracranial aneurysms (IAs). Noninvasive assessment of the inflammatory status of the aneurysm wall may guide the management of unruptured IAs by identifying reliable markers for increased rupture risk. METHODS: We conducted a qualitative systematic review following the ENTREQ (Enhancing Transparency in Reporting the Synthesis of Qualitative Research) framework. A search was made in MEDLINE/PubMed, Embase, and CINAHL from database inception to October 2017 using the terms "intracranial aneurysm" and "cerebral aneurysm" linked with the following key words: inflammation, hemodynamic(s), remodeling, macrophages, neutrophils, lymphocytes, complement system, vascular smooth muscle cells, mast cells, cytokines, and inflammatory biomarkers. RESULTS: One hundred and twenty-three articles were included in the review. CONCLUSIONS: In this systematic review, we explore the relationship between hemodynamic stress, inflammation, vascular remodeling, and the formation and rupture of IAs to develop novel strategies to predict the individual risk of aneurysmal rupture.
BACKGROUND: There seems to be a pathogenetic link between hemodynamics and inflammatory arterial wall alteration leading to the development and rupture of intracranial aneurysms (IAs). Noninvasive assessment of the inflammatory status of the aneurysm wall may guide the management of unruptured IAs by identifying reliable markers for increased rupture risk. METHODS: We conducted a qualitative systematic review following the ENTREQ (Enhancing Transparency in Reporting the Synthesis of Qualitative Research) framework. A search was made in MEDLINE/PubMed, Embase, and CINAHL from database inception to October 2017 using the terms "intracranial aneurysm" and "cerebral aneurysm" linked with the following key words: inflammation, hemodynamic(s), remodeling, macrophages, neutrophils, lymphocytes, complement system, vascular smooth muscle cells, mast cells, cytokines, and inflammatory biomarkers. RESULTS: One hundred and twenty-three articles were included in the review. CONCLUSIONS: In this systematic review, we explore the relationship between hemodynamic stress, inflammation, vascular remodeling, and the formation and rupture of IAs to develop novel strategies to predict the individual risk of aneurysmal rupture.
Authors: Joanna Kamińska; Violetta Dymicka-Piekarska; Robert Chrzanowski; Karol Sawicki; Anna J Milewska; Justyna Zińczuk; Marzena Tylicka; Marek Jadeszko; Zenon Mariak; Ewa M Kratz; Joanna Matowicka-Karna; Johannes Kornhuber; Piotr Lewczuk; Olga M Koper-Lenkiewicz Journal: J Inflamm Res Date: 2021-11-23