| Literature DB >> 29709260 |
Weijun Wei1, Dawei Jiang2, Emily B Ehlerding3, Quanyong Luo4, Weibo Cai5.
Abstract
The rapidly evolving field of cancer immunotherapy recently saw the approval of several new therapeutic antibodies. Several cell therapies, for example, chimeric antigen receptor-expressing T cells (CAR-T), are currently in clinical trials for a variety of cancers and other diseases. However, approaches to monitor changes in the immune status of tumors or to predict therapeutic responses are limited. Monitoring lymphocytes from whole blood or biopsies does not provide dynamic and spatial information about T cells in heterogeneous tumors. Positron emission tomography (PET) imaging using probes specific for T cells can noninvasively monitor systemic and intratumoral immune alterations during experimental therapies and may have an important and expanding value in the clinic.Entities:
Keywords: T cells; cancer; graft-versus-host disease (GVHD); immunotherapy; inflammation; positron emission tomography (PET); response prediction
Mesh:
Year: 2018 PMID: 29709260 PMCID: PMC6034116 DOI: 10.1016/j.trecan.2018.03.009
Source DB: PubMed Journal: Trends Cancer ISSN: 2405-8025