Literature DB >> 29707712

Coexisting order and disorder within a common 40-residue amyloid-β fibril structure in Alzheimer's disease brain tissue.

Ujjayini Ghosh1, Wai-Ming Yau, Robert Tycko.   

Abstract

Fibrils formed by 40- and 42-residue amyloid-β (Aβ40 and Aβ42) peptides exhibit molecular-level structural polymorphisms. A recent screen of fibrils derived from brain tissue of Alzheimer's disease patients revealed a single predominant Aβ40 polymorph. We present solid state nuclear magnetic resonance (ssNMR) data that define its coexisting structurally ordered and disordered segments.

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Year:  2018        PMID： 29707712      PMCID： PMC5953852          DOI： 10.1039/c8cc01967c

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  23 in total

1.  Multiple assembly pathways underlie amyloid-beta fibril polymorphisms.

Authors:  Claire Goldsbury; Peter Frey; Vesna Olivieri; Ueli Aebi; Shirley A Müller
Journal:  J Mol Biol       Date:  2005-09-16       Impact factor: 5.469

2.  Atomic Resolution Structure of Monomorphic Aβ42 Amyloid Fibrils.

Authors:  Michael T Colvin; Robert Silvers; Qing Zhe Ni; Thach V Can; Ivan Sergeyev; Melanie Rosay; Kevin J Donovan; Brian Michael; Joseph Wall; Sara Linse; Robert G Griffin
Journal:  J Am Chem Soc       Date:  2016-07-14       Impact factor: 15.419

3.  A new structural model of Aβ40 fibrils.

Authors:  Ivano Bertini; Leonardo Gonnelli; Claudio Luchinat; Jiafei Mao; Antonella Nesi
Journal:  J Am Chem Soc       Date:  2011-09-21       Impact factor: 15.419

4.  Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils.

Authors:  Aneta T Petkova; Richard D Leapman; Zhihong Guo; Wai-Ming Yau; Mark P Mattson; Robert Tycko
Journal:  Science       Date:  2005-01-14       Impact factor: 47.728

5.  Abeta(1-40) forms five distinct amyloid structures whose beta-sheet contents and fibril stabilities are correlated.

Authors:  Ravindra Kodali; Angela D Williams; Saketh Chemuru; Ronald Wetzel
Journal:  J Mol Biol       Date:  2010-06-18       Impact factor: 5.469

6.  Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer's disease.

Authors:  Jay Rasmussen; Jasmin Mahler; Natalie Beschorner; Stephan A Kaeser; Lisa M Häsler; Frank Baumann; Sofie Nyström; Erik Portelius; Kaj Blennow; Tammaryn Lashley; Nick C Fox; Diego Sepulveda-Falla; Markus Glatzel; Adrian L Oblak; Bernardino Ghetti; K Peter R Nilsson; Per Hammarström; Matthias Staufenbiel; Lary C Walker; Mathias Jucker
Journal:  Proc Natl Acad Sci U S A       Date:  2017-11-20       Impact factor: 11.205

7.  Fibril structure of amyloid-β(1-42) by cryo-electron microscopy.

Authors:  Lothar Gremer; Daniel Schölzel; Carla Schenk; Elke Reinartz; Jörg Labahn; Raimond B G Ravelli; Markus Tusche; Carmen Lopez-Iglesias; Wolfgang Hoyer; Henrike Heise; Dieter Willbold; Gunnar F Schröder
Journal:  Science       Date:  2017-09-07       Impact factor: 47.728

8.  Molecular structure of β-amyloid fibrils in Alzheimer's disease brain tissue.

Authors:  Jun-Xia Lu; Wei Qiang; Wai-Ming Yau; Charles D Schwieters; Stephen C Meredith; Robert Tycko
Journal:  Cell       Date:  2013-09-12       Impact factor: 41.582

9.  Aβ(1-42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease.

Authors:  Yiling Xiao; Buyong Ma; Dan McElheny; Sudhakar Parthasarathy; Fei Long; Minako Hoshi; Ruth Nussinov; Yoshitaka Ishii
Journal:  Nat Struct Mol Biol       Date:  2015-05-04       Impact factor: 15.369

10.  Abeta(1-40) fibril polymorphism implies diverse interaction patterns in amyloid fibrils.

Authors:  Jessica Meinhardt; Carsten Sachse; Peter Hortschansky; Nikolaus Grigorieff; Marcus Fändrich
Journal:  J Mol Biol       Date:  2008-11-14       Impact factor: 5.469
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  9 in total

1.  N-Terminal Modified Aβ Variants Enable Modulations to the Structures and Cytotoxicity Levels of Wild-Type Aβ Fibrils through Cross-Seeding.

Authors:  Zhi-Wen Hu; Dan Fai Au; Letticia Cruceta; Liliya Vugmeyster; Wei Qiang
Journal:  ACS Chem Neurosci       Date:  2020-07-06       Impact factor: 4.418

2.  Surveying the Energy Landscapes of Aβ Fibril Polymorphism.

Authors:  Mingchen Chen; Nicholas P Schafer; Peter G Wolynes
Journal:  J Phys Chem B       Date:  2018-10-01       Impact factor: 2.991

3.  Stability of Aβ-fibril fragments in the presence of fatty acids.

Authors:  Wenhui Xi; Elliott K Vanderford; Qinxin Liao; Ulrich H E Hansmann
Journal:  Protein Sci       Date:  2019-09-11       Impact factor: 6.725

4.  Automated picking of amyloid fibrils from cryo-EM images for helical reconstruction with RELION.

Authors:  Kent R Thurber; Yi Yin; Robert Tycko
Journal:  J Struct Biol       Date:  2021-04-06       Impact factor: 3.234

5.  Molecular structure of a prevalent amyloid-β fibril polymorph from Alzheimer's disease brain tissue.

Authors:  Ujjayini Ghosh; Kent R Thurber; Wai-Ming Yau; Robert Tycko
Journal:  Proc Natl Acad Sci U S A       Date:  2021-01-26       Impact factor: 12.779

6.  The amphibian antimicrobial peptide uperin 3.5 is a cross-α/cross-β chameleon functional amyloid.

Authors:  Nir Salinas; Einav Tayeb-Fligelman; Massimo D Sammito; Daniel Bloch; Raz Jelinek; Dror Noy; Isabel Usón; Meytal Landau
Journal:  Proc Natl Acad Sci U S A       Date:  2021-01-19       Impact factor: 12.779

7.  Structural differences in amyloid-β fibrils from brains of nondemented elderly individuals and Alzheimer's disease patients.

Authors:  Ujjayini Ghosh; Wai-Ming Yau; John Collinge; Robert Tycko
Journal:  Proc Natl Acad Sci U S A       Date:  2021-11-09       Impact factor: 12.779

8.  Fibrillization of 40-Residue β-Amyloid Peptides in Membrane-Like Environments Leads to Different Fibril Structures and Reduced Molecular Polymorphisms.

Authors:  Qinghui Cheng; Zhi-Wen Hu; Yuto Tobin-Miyaji; Amy E Perkins; Terrence Deak; Wei Qiang
Journal:  Biomolecules       Date:  2020-06-08

9.  The Cryo-EM structures of two amphibian antimicrobial cross-β amyloid fibrils.

Authors:  Robert Bücker; Carolin Seuring; Cornelia Cazey; Katharina Veith; Maria García-Alai; Kay Grünewald; Meytal Landau
Journal:  Nat Commun       Date:  2022-07-27       Impact factor: 17.694
  9 in total

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