| Literature DB >> 29706686 |
Noah J Kolodziejski1, Christopher J Stapels1, Daniel R McAdams1, Daniel E Fernandez1, Matthew J Podolsky1, Dana Farkas1,2, Brent B Ward3, Mark Vartarian3, Stephen E Feinberg3, Seung Yup Lee4, Urmi Parikh4, Mary-Ann Mycek4, James F Christian1.
Abstract
The vascularization and resulting perfusion of transferred tissues are critical to the success of grafts in buried free flap transplantations. To enable long-term clinical monitoring of grafted tissue perfusion during neovascularization and endothelialization, we are developing an implantable instrument for the continuous monitoring of perfusion using diffuse correlation spectroscopy (DCS), and augmented with diffuse reflectance spectroscopy (DRS). This work discusses instrument construction, integration, and preliminary results using a porcine graft model.Entities:
Keywords: Buried free flap; Continuous perfusion monitoring; Diffuse correlation spectroscopy; Diffuse reflectance spectroscopy; Implantable optical monitoring; Maxillofacial transplantation; Microcirculation; Perfusion monitoring
Year: 2016 PMID: 29706686 PMCID: PMC5916819 DOI: 10.1117/12.2212872
Source DB: PubMed Journal: Proc SPIE Int Soc Opt Eng ISSN: 0277-786X