Jason Y Y Wong1, Helene G Margolis2, Mitchell Machiela3, Weiyin Zhou4, Michelle C Odden5, Bruce M Psaty6, John Robbins2, Rena R Jones3, Jerome I Rotter7, Stephen J Chanock3, Nathaniel Rothman3, Qing Lan3, Jennifer S Lee8. 1. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA. Electronic address: jason.wong@nih.gov. 2. Department of Internal Medicine, School of Medicine, University of California, Davis, CA, USA. 3. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA. 4. Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Leidos Biomedical Research Inc., Bethesda, MD, USA. 5. School of Biological and Population Health Sciences, Oregon State University, Corvallis, OR, USA. 6. Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA. 7. Institute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles BioMedical Research Institute, Harbor-UCLA Medical Center, Torrance, CA, USA. 8. Division of Endocrinology, Gerontology, and Metabolism, Department of Medicine, and Division of Epidemiology, Department of Health Research and Policy, School of Medicine, Stanford University, Stanford, CA, USA; Medical Services, Veteran Affairs, Palo Alto, Health Care System, CA, USA.
Abstract
BACKGROUND: Mosaic loss of chromosome Y (mLOY) can occur in a fraction of cells as men age, which is potentially linked to increased mortality risk. Smoking is related to mLOY; however, the contribution of air pollution is unclear. OBJECTIVE: We investigated whether exposure to outdoor air pollution, age, and smoking were associated with mLOY. METHODS: We analyzed baseline (1989-1993) blood samples from 933 men ≥65 years of age from the prospective Cardiovascular Health Study. Particulate matter ≤10 μm (PM10), carbon monoxide, nitrogen dioxide, sulfur dioxide, and ozone data were obtained from the U.S. EPA Aerometric Information Retrieval System for the year prior to baseline. Inverse-distance weighted air monitor data were used to estimate each participants' monthly residential exposure. mLOY was detected with standard methods using signal intensity (median log-R ratio (mLRR)) of the male-specific chromosome Y regions from Illumina array data. Linear regression models were used to evaluate relations between mean exposure in the prior year, age, smoking and continuous mLRR. RESULTS: Increased PM10 was associated with mLOY, namely decreased mLRR (p-trend = 0.03). Compared with the lowest tertile (≤28.5 μg/m3), the middle (28.5-31.0 μg/m3; β = -0.0044, p = 0.09) and highest (≥31 μg/m3; β = -0.0054, p = 0.04) tertiles had decreased mLRR, adjusted for age, clinic, race/cohort, smoking status and pack-years. Additionally, increasing age (β = -0.00035, p = 0.06) and smoking pack-years (β = -0.00011, p = 1.4E-3) were associated with decreased mLRR, adjusted for each other and race/cohort. No significant associations were found for other pollutants. CONCLUSIONS: PM10 may increase leukocyte mLOY, a marker of genomic instability. The sample size was modest and replication is warranted.
BACKGROUND: Mosaic loss of chromosome Y (mLOY) can occur in a fraction of cells as men age, which is potentially linked to increased mortality risk. Smoking is related to mLOY; however, the contribution of air pollution is unclear. OBJECTIVE: We investigated whether exposure to outdoor air pollution, age, and smoking were associated with mLOY. METHODS: We analyzed baseline (1989-1993) blood samples from 933 men ≥65 years of age from the prospective Cardiovascular Health Study. Particulate matter ≤10 μm (PM10), carbon monoxide, nitrogen dioxide, sulfur dioxide, and ozone data were obtained from the U.S. EPA Aerometric Information Retrieval System for the year prior to baseline. Inverse-distance weighted air monitor data were used to estimate each participants' monthly residential exposure. mLOY was detected with standard methods using signal intensity (median log-R ratio (mLRR)) of the male-specific chromosome Y regions from Illumina array data. Linear regression models were used to evaluate relations between mean exposure in the prior year, age, smoking and continuous mLRR. RESULTS: Increased PM10 was associated with mLOY, namely decreased mLRR (p-trend = 0.03). Compared with the lowest tertile (≤28.5 μg/m3), the middle (28.5-31.0 μg/m3; β = -0.0044, p = 0.09) and highest (≥31 μg/m3; β = -0.0054, p = 0.04) tertiles had decreased mLRR, adjusted for age, clinic, race/cohort, smoking status and pack-years. Additionally, increasing age (β = -0.00035, p = 0.06) and smoking pack-years (β = -0.00011, p = 1.4E-3) were associated with decreased mLRR, adjusted for each other and race/cohort. No significant associations were found for other pollutants. CONCLUSIONS: PM10 may increase leukocyte mLOY, a marker of genomic instability. The sample size was modest and replication is warranted.
Authors: Paul J Villeneuve; Scott A Weichenthal; Daniel Crouse; Anthony B Miller; Teresa To; Randall V Martin; Aaron van Donkelaar; Claus Wall; Richard T Burnett Journal: Epidemiology Date: 2015-07 Impact factor: 4.822
Authors: D W Dockery; C A Pope; X Xu; J D Spengler; J H Ware; M E Fay; B G Ferris; F E Speizer Journal: N Engl J Med Date: 1993-12-09 Impact factor: 91.245
Authors: Sandrah P Eckel; Myles Cockburn; Yu-Hsiang Shu; Huiyu Deng; Frederick W Lurmann; Lihua Liu; Frank D Gilliland Journal: Thorax Date: 2016-08-04 Impact factor: 9.102
Authors: Mitchell J Machiela; Weiyin Zhou; Eric Karlins; Joshua N Sampson; Neal D Freedman; Qi Yang; Belynda Hicks; Casey Dagnall; Christopher Hautman; Kevin B Jacobs; Christian C Abnet; Melinda C Aldrich; Christopher Amos; Laufey T Amundadottir; Alan A Arslan; Laura E Beane-Freeman; Sonja I Berndt; Amanda Black; William J Blot; Cathryn H Bock; Paige M Bracci; Louise A Brinton; H Bas Bueno-de-Mesquita; Laurie Burdett; Julie E Buring; Mary A Butler; Federico Canzian; Tania Carreón; Kari G Chaffee; I-Shou Chang; Nilanjan Chatterjee; Chu Chen; Constance Chen; Kexin Chen; Charles C Chung; Linda S Cook; Marta Crous Bou; Michael Cullen; Faith G Davis; Immaculata De Vivo; Ti Ding; Jennifer Doherty; Eric J Duell; Caroline G Epstein; Jin-Hu Fan; Jonine D Figueroa; Joseph F Fraumeni; Christine M Friedenreich; Charles S Fuchs; Steven Gallinger; Yu-Tang Gao; Susan M Gapstur; Montserrat Garcia-Closas; Mia M Gaudet; J Michael Gaziano; Graham G Giles; Elizabeth M Gillanders; Edward L Giovannucci; Lynn Goldin; Alisa M Goldstein; Christopher A Haiman; Goran Hallmans; Susan E Hankinson; Curtis C Harris; Roger Henriksson; Elizabeth A Holly; Yun-Chul Hong; Robert N Hoover; Chao A Hsiung; Nan Hu; Wei Hu; David J Hunter; Amy Hutchinson; Mazda Jenab; Christoffer Johansen; Kay-Tee Khaw; Hee Nam Kim; Yeul Hong Kim; Young Tae Kim; Alison P Klein; Robert Klein; Woon-Puay Koh; Laurence N Kolonel; Charles Kooperberg; Peter Kraft; Vittorio Krogh; Robert C Kurtz; Andrea LaCroix; Qing Lan; Maria Teresa Landi; Loic Le Marchand; Donghui Li; Xiaolin Liang; Linda M Liao; Dongxin Lin; Jianjun Liu; Jolanta Lissowska; Lingeng Lu; Anthony M Magliocco; Nuria Malats; Keitaro Matsuo; Lorna H McNeill; Robert R McWilliams; Beatrice S Melin; Lisa Mirabello; Lee Moore; Sara H Olson; Irene Orlow; Jae Yong Park; Ana Patiño-Garcia; Beata Peplonska; Ulrike Peters; Gloria M Petersen; Loreall Pooler; Jennifer Prescott; Ludmila Prokunina-Olsson; Mark P Purdue; You-Lin Qiao; Preetha Rajaraman; Francisco X Real; Elio Riboli; Harvey A Risch; Benjamin Rodriguez-Santiago; Avima M Ruder; Sharon A Savage; Fredrick Schumacher; Ann G Schwartz; Kendra L Schwartz; Adeline Seow; Veronica Wendy Setiawan; Gianluca Severi; Hongbing Shen; Xin Sheng; Min-Ho Shin; Xiao-Ou Shu; Debra T Silverman; Margaret R Spitz; Victoria L Stevens; Rachael Stolzenberg-Solomon; Daniel Stram; Ze-Zhong Tang; Philip R Taylor; Lauren R Teras; Geoffrey S Tobias; David Van Den Berg; Kala Visvanathan; Sholom Wacholder; Jiu-Cun Wang; Zhaoming Wang; Nicolas Wentzensen; William Wheeler; Emily White; John K Wiencke; Brian M Wolpin; Maria Pik Wong; Chen Wu; Tangchun Wu; Xifeng Wu; Yi-Long Wu; Jay S Wunder; Lucy Xia; Hannah P Yang; Pan-Chyr Yang; Kai Yu; Krista A Zanetti; Anne Zeleniuch-Jacquotte; Wei Zheng; Baosen Zhou; Regina G Ziegler; Luis A Perez-Jurado; Neil E Caporaso; Nathaniel Rothman; Margaret Tucker; Michael C Dean; Meredith Yeager; Stephen J Chanock Journal: Nat Commun Date: 2016-06-13 Impact factor: 14.919
Authors: Alejandro Cáceres; Aina Jene; Tonu Esko; Luis A Pérez-Jurado; Juan R González Journal: J Natl Cancer Inst Date: 2020-09-01 Impact factor: 13.506
Authors: Hanna Davies; Edyta Rychlicka-Buniowska; Jonas Mattisson; Behrooz Torabi Moghadam; Jan P Dumanski; Jonatan Halvardson; Noemi Nagy; Kazimierz Węglarczyk; Karolina Bukowska-Strakova; Marcus Danielsson; Paweł Olszewski; Arkadiusz Piotrowski; Erin Oerton; Aleksandra Ambicka; Marcin Przewoźnik; Łukasz Bełch; Tomasz Grodzicki; Piotr L Chłosta; Stefan Imreh; Vilmantas Giedraitis; Lena Kilander; Jessica Nordlund; Adam Ameur; Ulf Gyllensten; Åsa Johansson; Alicja Józkowicz; Maciej Siedlar; Alicja Klich-Rączka; Janusz Jaszczyński; Stefan Enroth; Jarosław Baran; Martin Ingelsson; John R B Perry; Janusz Ryś; Lars A Forsberg Journal: Cell Mol Life Sci Date: 2021-04-10 Impact factor: 9.261
Authors: Shu-Hong Lin; Youjin Wang; Stephen W Hartley; Danielle M Karyadi; Olivia W Lee; Bin Zhu; Weiyin Zhou; Derek W Brown; Erin Beilstein-Wedel; Rohan Hazra; Deborah Kacanek; Ellen G Chadwick; Carmen J Marsit; Miriam C Poirier; Sean S Brummel; Stephen J Chanock; Eric A Engels; Mitchell J Machiela Journal: AIDS Date: 2021-08-01 Impact factor: 4.632