Literature DB >> 29694240

Analysis of a Novel pncA Mutation for Susceptibility to Pyrazinamide Therapy.

Malancha Karmakar1, Maria Globan1,2, Janet A M Fyfe1,2, Timothy P Stinear1, Paul D R Johnson1,3, Natasha E Holmes1,4, Justin T Denholm1, David B Ascher1,5.   

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Year:  2018        PMID： 29694240      PMCID： PMC6118032          DOI： 10.1164/rccm.201712-2572LE

Source DB:  PubMed          Journal:  Am J Respir Crit Care Med        ISSN： 1073-449X            Impact factor:   21.405


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  11 in total

Review 1.  Pyrazinamide susceptibility testing in Mycobacterium tuberculosis: a systematic review with meta-analyses.

Authors:  Kwok Chiu Chang; Wing Wai Yew; Ying Zhang
Journal:  Antimicrob Agents Chemother       Date:  2011-07-18       Impact factor: 5.191

2.  Mechanisms of Pyrazinamide Action and Resistance.

Authors:  Ying Zhang; Wanliang Shi; Wenhong Zhang; Denis Mitchison
Journal:  Microbiol Spectr       Date:  2013

3.  Evaluation of methods for testing the susceptibility of clinical Mycobacterium tuberculosis isolates to pyrazinamide.

Authors:  Zhenling Cui; Jie Wang; Junmei Lu; Xiaochen Huang; Ruijuan Zheng; Zhongyi Hu
Journal:  J Clin Microbiol       Date:  2013-02-06       Impact factor: 5.948

4.  Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium tuberculosis.

Authors:  Yumi Park; Angela Pacitto; Tracy Bayliss; Laura A T Cleghorn; Zhe Wang; Travis Hartman; Kriti Arora; Thomas R Ioerger; Jim Sacchettini; Menico Rizzi; Stefano Donini; Tom L Blundell; David B Ascher; Kyu Rhee; Ardala Breda; Nian Zhou; Veronique Dartois; Surendranadha Reddy Jonnala; Laura E Via; Valerie Mizrahi; Ola Epemolu; Laste Stojanovski; Fred Simeons; Maria Osuna-Cabello; Lucy Ellis; Claire J MacKenzie; Alasdair R C Smith; Susan H Davis; Dinakaran Murugesan; Kirsteen I Buchanan; Penelope A Turner; Margaret Huggett; Fabio Zuccotto; Maria Jose Rebollo-Lopez; Maria Jose Lafuente-Monasterio; Olalla Sanz; Gracia Santos Diaz; Joël Lelièvre; Lluis Ballell; Carolyn Selenski; Matthew Axtman; Sonja Ghidelli-Disse; Hannah Pflaumer; Markus Bösche; Gerard Drewes; Gail M Freiberg; Matthew D Kurnick; Myron Srikumaran; Dale J Kempf; Simon R Green; Peter C Ray; Kevin Read; Paul Wyatt; Clifton E Barry; Helena I Boshoff
Journal:  ACS Infect Dis       Date:  2016-10-17       Impact factor: 5.084

5.  Crystal structure of the pyrazinamidase of Mycobacterium tuberculosis: insights into natural and acquired resistance to pyrazinamide.

Authors:  Stéphanie Petrella; Nathalie Gelus-Ziental; Arnaud Maudry; Caroline Laurans; Rachid Boudjelloul; Wladimir Sougakoff
Journal:  PLoS One       Date:  2011-01-24       Impact factor: 3.240

6.  Mycobacterium tuberculosis pyrazinamide resistance determinants: a multicenter study.

Authors:  Paolo Miotto; Andrea M Cabibbe; Silke Feuerriegel; Nicola Casali; Francis Drobniewski; Yulia Rodionova; Daiva Bakonyte; Petras Stakenas; Edita Pimkina; Ewa Augustynowicz-Kopeć; Massimo Degano; Alessandro Ambrosi; Sven Hoffner; Mikael Mansjö; Jim Werngren; Sabine Rüsch-Gerdes; Stefan Niemann; Daniela M Cirillo
Journal:  mBio       Date:  2014-10-21       Impact factor: 7.867

7.  A comprehensive characterization of PncA polymorphisms that confer resistance to pyrazinamide.

Authors:  Adam N Yadon; Kashmeel Maharaj; John H Adamson; Yi-Pin Lai; James C Sacchettini; Thomas R Ioerger; Eric J Rubin; Alexander S Pym
Journal:  Nat Commun       Date:  2017-09-19       Impact factor: 14.919

8.  The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis.

Authors:  Vinayak Singh; Stefano Donini; Angela Pacitto; Claudia Sala; Ruben C Hartkoorn; Neeraj Dhar; Gyorgy Keri; David B Ascher; Guillaume Mondésert; Anthony Vocat; Andréanne Lupien; Raphael Sommer; Hélène Vermet; Sophie Lagrange; Joe Buechler; Digby F Warner; John D McKinney; Janos Pato; Stewart T Cole; Tom L Blundell; Menico Rizzi; Valerie Mizrahi
Journal:  ACS Infect Dis       Date:  2016-09-08       Impact factor: 5.084

9.  Arpeggio: A Web Server for Calculating and Visualising Interatomic Interactions in Protein Structures.

Authors:  Harry C Jubb; Alicia P Higueruelo; Bernardo Ochoa-Montaño; Will R Pitt; David B Ascher; Tom L Blundell
Journal:  J Mol Biol       Date:  2016-12-10       Impact factor: 5.469

10.  In silico functional dissection of saturation mutagenesis: Interpreting the relationship between phenotypes and changes in protein stability, interactions and activity.

Authors:  Douglas E V Pires; Jing Chen; Tom L Blundell; David B Ascher
Journal:  Sci Rep       Date:  2016-01-22       Impact factor: 4.379
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  18 in total

1.  mmCSM-AB: guiding rational antibody engineering through multiple point mutations.

Authors:  Yoochan Myung; Douglas E V Pires; David B Ascher
Journal:  Nucleic Acids Res       Date:  2020-07-02       Impact factor: 16.971

2.  Drug Degradation Caused by mce3R Mutations Confers Contezolid (MRX-I) Resistance in Mycobacterium tuberculosis.

Authors:  Rui Pi; Xiaomin Chen; Jian Meng; Qingyun Liu; Yiwang Chen; Cheng Bei; Chuan Wang; Qian Gao
Journal:  Antimicrob Agents Chemother       Date:  2022-10-03       Impact factor: 5.938

3.  ThermoMutDB: a thermodynamic database for missense mutations.

Authors:  Joicymara S Xavier; Thanh-Binh Nguyen; Malancha Karmarkar; Stephanie Portelli; Pâmela M Rezende; João P L Velloso; David B Ascher; Douglas E V Pires
Journal:  Nucleic Acids Res       Date:  2021-01-08       Impact factor: 16.971

4.  Kinact: a computational approach for predicting activating missense mutations in protein kinases.

Authors:  Carlos Hm Rodrigues; David B Ascher; Douglas Ev Pires
Journal:  Nucleic Acids Res       Date:  2018-07-02       Impact factor: 16.971

5.  Empirical ways to identify novel Bedaquiline resistance mutations in AtpE.

Authors:  Malancha Karmakar; Carlos H M Rodrigues; Kathryn E Holt; Sarah J Dunstan; Justin Denholm; David B Ascher
Journal:  PLoS One       Date:  2019-05-29       Impact factor: 3.240

6.  Structure guided prediction of Pyrazinamide resistance mutations in pncA.

Authors:  Malancha Karmakar; Carlos H M Rodrigues; Kristy Horan; Justin T Denholm; David B Ascher
Journal:  Sci Rep       Date:  2020-02-05       Impact factor: 4.379

7.  mCSM-membrane: predicting the effects of mutations on transmembrane proteins.

Authors:  Douglas E V Pires; Carlos H M Rodrigues; David B Ascher
Journal:  Nucleic Acids Res       Date:  2020-07-02       Impact factor: 16.971

8.  Artificial Intelligence and Machine learning based prediction of resistant and susceptible mutations in Mycobacterium tuberculosis.

Authors:  Salma Jamal; Mohd Khubaib; Rishabh Gangwar; Sonam Grover; Abhinav Grover; Seyed E Hasnain
Journal:  Sci Rep       Date:  2020-03-26       Impact factor: 4.379

9.  Computational saturation mutagenesis to predict structural consequences of systematic mutations in the beta subunit of RNA polymerase in Mycobacterium leprae.

Authors:  Sundeep Chaitanya Vedithi; Carlos H M Rodrigues; Stephanie Portelli; Marcin J Skwark; Madhusmita Das; David B Ascher; Tom L Blundell; Sony Malhotra
Journal:  Comput Struct Biotechnol J       Date:  2020-01-17       Impact factor: 7.271

10.  Synthesis and Structure-Activity relationship of 1-(5-isoquinolinesulfonyl)piperazine analogues as inhibitors of Mycobacterium tuberculosis IMPDH.

Authors:  Vinayak Singh; Angela Pacitto; Stefano Donini; Davide M Ferraris; Sándor Boros; Eszter Illyés; Bálint Szokol; Menico Rizzi; Tom L Blundell; David B Ascher; Janos Pato; Valerie Mizrahi
Journal:  Eur J Med Chem       Date:  2019-04-15       Impact factor: 6.514
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