Literature DB >> 29693099

Deciphering the role of substrate stiffness in enhancing the internalization efficiency of plasmid DNA in stem cells using lipid-based nanocarriers.

Saman Modaresi1, Settimio Pacelli, Jonathan Whitlow, Arghya Paul.   

Abstract

This study investigates the role of substrate stiffness in the non-viral transfection of human adipose-derived stem cells (hASCs) with the aim to maximize the hASC expression of vascular endothelial growth factor (VEGF). The results confirm the direct effect of substrate stiffness in regulating cytoskeletal remodeling and corresponding plasmid internalization.

Entities:  

Mesh：

Substances：

Year:  2018        PMID： 29693099      PMCID： PMC5957767          DOI： 10.1039/c8nr01516c

Source DB:  PubMed          Journal:  Nanoscale        ISSN： 2040-3364            Impact factor:   7.790


  34 in total

1.  Cationic liposome and plasmid DNA complexes formed in serum-free medium under optimum transfection condition are negatively charged.

Authors:  K K Son; D H Patel; D Tkach; A Park
Journal:  Biochim Biophys Acta       Date:  2000-06-01

2.  Fibroblast polarization is a matrix-rigidity-dependent process controlled by focal adhesion mechanosensing.

Authors:  Masha Prager-Khoutorsky; Alexandra Lichtenstein; Ramaswamy Krishnan; Kavitha Rajendran; Avi Mayo; Zvi Kam; Benjamin Geiger; Alexander D Bershadsky
Journal:  Nat Cell Biol       Date:  2011-11-13       Impact factor: 28.824

Review 3.  Human adipose-derived stem cells: current challenges and clinical perspectives.

Authors:  Samira Yarak; Oswaldo Keith Okamoto
Journal:  An Bras Dermatol       Date:  2010 Sep-Oct       Impact factor: 1.896

Review 4.  Intracellular trafficking of nonviral vectors.

Authors:  L K Medina-Kauwe; J Xie; S Hamm-Alvarez
Journal:  Gene Ther       Date:  2005-12       Impact factor: 5.250

5.  Non-viral gene delivery regulated by stiffness of cell adhesion substrates.

Authors:  Hyun Joon Kong; Jodi Liu; Kathryn Riddle; Takuya Matsumoto; Kent Leach; David J Mooney
Journal:  Nat Mater       Date:  2005-05-15       Impact factor: 43.841

Review 6.  Non viral vectors in gene therapy- an overview.

Authors:  Murali Ramamoorth; Aparna Narvekar
Journal:  J Clin Diagn Res       Date:  2015-01-01

7.  Nanodiamond-based injectable hydrogel for sustained growth factor release: Preparation, characterization and in vitro analysis.

Authors:  Settimio Pacelli; Francisca Acosta; Aparna R Chakravarti; Saheli G Samanta; Jonathan Whitlow; Saman Modaresi; Rafeeq P H Ahmed; Johnson Rajasingh; Arghya Paul
Journal:  Acta Biomater       Date:  2017-05-19       Impact factor: 8.947

8.  Emerging links between surface nanotechnology and endocytosis: impact on nonviral gene delivery.

Authors:  Andrew F Adler; Kam W Leong
Journal:  Nano Today       Date:  2010-12-01       Impact factor: 20.722

9.  The intracellular trafficking mechanism of Lipofectamine-based transfection reagents and its implication for gene delivery.

Authors:  Francesco Cardarelli; Luca Digiacomo; Cristina Marchini; Augusto Amici; Fabrizio Salomone; Giuseppe Fiume; Alessandro Rossetta; Enrico Gratton; Daniela Pozzi; Giulio Caracciolo
Journal:  Sci Rep       Date:  2016-05-11       Impact factor: 4.379

10.  Controlling Adult Stem Cell Behavior Using Nanodiamond-Reinforced Hydrogel: Implication in Bone Regeneration Therapy.

Authors:  Settimio Pacelli; Ryan Maloney; Aparna R Chakravarti; Jonathan Whitlow; Sayantani Basu; Saman Modaresi; Stevin Gehrke; Arghya Paul
Journal:  Sci Rep       Date:  2017-07-26       Impact factor: 4.379
View more
  5 in total

Review 1.  Biomaterial substrate modifications that influence cell-material interactions to prime cellular responses to nonviral gene delivery.

Authors:  Amy Mantz; Angela K Pannier
Journal:  Exp Biol Med (Maywood)       Date:  2019-01-08

2.  Development of a fibrin-mediated gene delivery system for the treatment of cystinosis via design of experiment.

Authors:  Valeria Graceffa
Journal:  Sci Rep       Date:  2022-03-08       Impact factor: 4.379

3.  Biomechanical Dependence of SARS-CoV-2 Infections.

Authors:  Alexandra Paul; Sachin Kumar; Tamer S Kaoud; Madison R Pickett; Amanda L Bohanon; Janet Zoldan; Kevin N Dalby; Sapun H Parekh
Journal:  ACS Appl Bio Mater       Date:  2022-04-29

Review 4.  Physical and mechanical cues affecting biomaterial-mediated plasmid DNA delivery: insights into non-viral delivery systems.

Authors:  Valeria Graceffa
Journal:  J Genet Eng Biotechnol       Date:  2021-06-17

Review 5.  Nucleic acid delivery to mesenchymal stem cells: a review of nonviral methods and applications.

Authors:  Andrew Hamann; Albert Nguyen; Angela K Pannier
Journal:  J Biol Eng       Date:  2019-01-18       Impact factor: 4.355
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.