| Literature DB >> 30621454 |
Amy Mantz1, Angela K Pannier1.
Abstract
IMPACT STATEMENT: This review summarizes how biomaterial substrate modifications (e.g. chemical modifications like natural coatings, ligands, or functional side groups, and/or physical modifications such as topography or stiffness) can prime the cellular response to nonviral gene delivery (e.g. affecting integrin binding and focal adhesion formation, cytoskeletal remodeling, endocytic mechanisms, and intracellular trafficking), to aid in improving gene delivery for applications where a cell-material interface might exist (e.g. tissue engineering scaffolds, medical implants and devices, sensors and diagnostics, wound dressings).Entities:
Keywords: Biomaterials; biotechnology; extracellular matrix; gene delivery; priming; transfection
Mesh:
Substances:
Year: 2019 PMID: 30621454 PMCID: PMC6405826 DOI: 10.1177/1535370218821060
Source DB: PubMed Journal: Exp Biol Med (Maywood) ISSN: 1535-3699