Andrei A Puiu1, Olga Wudarczyk2, Katharina S Goerlich3, Mikhail Votinov4, Beate Herpertz-Dahlmann5, Bruce Turetsky6, Kerstin Konrad7. 1. Child Neuropsychology Section, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Medical Faculty, RWTH Aachen University, Aachen, Germany. Electronic address: apuiu@ukaachen.de. 2. Department of Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty, RWTH Aachen University, Aachen, Germany. Electronic address: owudarczyk@ukaachen.de. 3. Department of Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty, RWTH Aachen University, Aachen, Germany; Department of Neuroscience, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address: kgoerlich@ukaachen.de. 4. Department of Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty, RWTH Aachen University, Aachen, Germany; JARA-Institute Brain Structure-Function Relationship, Research Center Jülich and RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany; Institute of Neuroscience and Medicine 10, Research Center Jülich, Aachen, Germany. Electronic address: mvotinov@ukaachen.de. 5. Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Medical Faculty, RWTH Aachen University, Aachen, Germany. Electronic address: bherpertz@ukaachen.de. 6. Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: turetsky@mail.med.upenn.edu. 7. Child Neuropsychology Section, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Medical Faculty, RWTH Aachen University, Aachen, Germany. Electronic address: kkonrad@ukaachen.de.
Abstract
BACKGROUND: Although impulsive aggression (IA) and dysfunctional response inhibition (RI) are hallmarks of attention-deficit/hyperactivity disorder (ADHD) and disrupted behavioral disorders (DBDs), little is known about their shared and distinct deviant neural mechanisms. AIMS AND METHODS: Here, we selectively reviewed s/fMRI ADHD and DBD studies to identify disorder-specific and shared IA and RI aberrant neural mechanisms. RESULTS: In ADHD, deviant prefrontal and cingulate functional activity was associated with increased IA. Structural alterations were most pronounced in the cingulate cortex. Subjects with DBDs showed marked cortico-subcortical dysfunctions. ADHD and DBDs share similar cortico-limbic structural and functional alterations. RI deficits in ADHD highlighted hypoactivity in the dorso/ventro-lateral PFC, insula, and striatum, while the paralimbic system was primarily dysfunctional in DBDs. Across disorders, extensively altered cortico-limbic dysfunctions underlie IA, while RI was mostly associated with aberrant prefrontal activity. CONCLUSION: Control network deficits were evidenced across clinical phenotypes in IA and RI. Dysfunctions at any level within these cortico-subcortical projections lead to deficient cognitive-affective control by ascribing emotional salience to otherwise irrelevant stimuli. The clinical implications of these findings are discussed.
BACKGROUND: Although impulsive aggression (IA) and dysfunctional response inhibition (RI) are hallmarks of attention-deficit/hyperactivity disorder (ADHD) and disrupted behavioral disorders (DBDs), little is known about their shared and distinct deviant neural mechanisms. AIMS AND METHODS: Here, we selectively reviewed s/fMRI ADHD and DBD studies to identify disorder-specific and shared IA and RI aberrant neural mechanisms. RESULTS: In ADHD, deviant prefrontal and cingulate functional activity was associated with increased IA. Structural alterations were most pronounced in the cingulate cortex. Subjects with DBDs showed marked cortico-subcortical dysfunctions. ADHD and DBDs share similar cortico-limbic structural and functional alterations. RI deficits in ADHD highlighted hypoactivity in the dorso/ventro-lateral PFC, insula, and striatum, while the paralimbic system was primarily dysfunctional in DBDs. Across disorders, extensively altered cortico-limbic dysfunctions underlie IA, while RI was mostly associated with aberrant prefrontal activity. CONCLUSION: Control network deficits were evidenced across clinical phenotypes in IA and RI. Dysfunctions at any level within these cortico-subcortical projections lead to deficient cognitive-affective control by ascribing emotional salience to otherwise irrelevant stimuli. The clinical implications of these findings are discussed.
Authors: Jessica N Smith; Joseph S Raiker; Whitney D Fosco; Morgan L Jusko; Mileini Campez; Kelcey Little; Aaron Mattfeld; Kisbel Espinal; Gabriela Sanchez; Brittany Merrill; Erica D Musser; Elizabeth Gnagy; Andrew Greiner; Erika Coles; William E Pelham Journal: J Abnorm Child Psychol Date: 2020-09
Authors: Martine Hoogman; Ryan Muetzel; Joao P Guimaraes; Elena Shumskaya; Maarten Mennes; Marcel P Zwiers; Neda Jahanshad; Gustavo Sudre; Thomas Wolfers; Eric A Earl; Juan Carlos Soliva Vila; Yolanda Vives-Gilabert; Sabin Khadka; Stephanie E Novotny; Catharina A Hartman; Dirk J Heslenfeld; Lizanne J S Schweren; Sara Ambrosino; Bob Oranje; Patrick de Zeeuw; Tiffany M Chaim-Avancini; Pedro G P Rosa; Marcus V Zanetti; Charles B Malpas; Gregor Kohls; Georg G von Polier; Jochen Seitz; Joseph Biederman; Alysa E Doyle; Anders M Dale; Theo G M van Erp; Jeffery N Epstein; Terry L Jernigan; Ramona Baur-Streubel; Georg C Ziegler; Kathrin C Zierhut; Anouk Schrantee; Marie F Høvik; Astri J Lundervold; Clare Kelly; Hazel McCarthy; Norbert Skokauskas; Ruth L O'Gorman Tuura; Anna Calvo; Sara Lera-Miguel; Rosa Nicolau; Kaylita C Chantiluke; Anastasia Christakou; Alasdair Vance; Mara Cercignani; Matt C Gabel; Philip Asherson; Sarah Baumeister; Daniel Brandeis; Sarah Hohmann; Ivanei E Bramati; Fernanda Tovar-Moll; Andreas J Fallgatter; Bernd Kardatzki; Lena Schwarz; Anatoly Anikin; Alexandr Baranov; Tinatin Gogberashvili; Dmitry Kapilushniy; Anastasia Solovieva; Hanan El Marroun; Tonya White; Georgii Karkashadze; Leyla Namazova-Baranova; Thomas Ethofer; Paulo Mattos; Tobias Banaschewski; David Coghill; Kerstin J Plessen; Jonna Kuntsi; Mitul A Mehta; Yannis Paloyelis; Neil A Harrison; Mark A Bellgrove; Tim J Silk; Ana I Cubillo; Katya Rubia; Luisa Lazaro; Silvia Brem; Susanne Walitza; Thomas Frodl; Mariam Zentis; Francisco X Castellanos; Yuliya N Yoncheva; Jan Haavik; Liesbeth Reneman; Annette Conzelmann; Klaus-Peter Lesch; Paul Pauli; Andreas Reif; Leanne Tamm; Kerstin Konrad; Eileen Oberwelland Weiss; Geraldo F Busatto; Mario R Louza; Sarah Durston; Pieter J Hoekstra; Jaap Oosterlaan; Michael C Stevens; J Antoni Ramos-Quiroga; Oscar Vilarroya; Damien A Fair; Joel T Nigg; Paul M Thompson; Jan K Buitelaar; Stephen V Faraone; Philip Shaw; Henning Tiemeier; Janita Bralten; Barbara Franke Journal: Am J Psychiatry Date: 2019-04-24 Impact factor: 18.112
Authors: Andrei A Puiu; Olga Wudarczyk; Gregor Kohls; Danilo Bzdok; Beate Herpertz-Dahlmann; Kerstin Konrad Journal: Hum Brain Mapp Date: 2020-04-21 Impact factor: 5.038