| Literature DB >> 29685284 |
Albert M Anderson1, David Croteau2, Ronald J Ellis2, Debra Rosario3, Michael Potter3, Gilles J Guillemin4, Bruce J Brew5, Steven Paul Woods6, Scott L Letendre3.
Abstract
There is mounting evidence that prospective memory (PM) is impaired during HIV infection despite treatment. In this prospective study, 66 adults (43 HIV+ and 23 HIV negative) underwent PM assessment and cerebrospinal fluid (CSF) examination. HIV+ participants had significantly lower PM but significantly higher CSF concentrations of CXCL10 and quinolinic acid (QUIN). Higher CSF phosphorylated Tau (pTau) was associated with worse PM. In a secondary analysis excluding outliers, higher QUIN correlated with higher pTau. CSF QUIN is thus elevated during HIV infection despite antiretroviral therapy and could indirectly contribute to impaired PM by influencing the formation of pTau.Entities:
Keywords: Acquired immunodeficiency syndrome; Cerebrospinal fluid; Human immunodeficiency virus; Neurocognitive disorder; Tau proteins; Tryptophan
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Year: 2018 PMID： 29685284 PMCID： PMC5918423 DOI： 10.1016/j.jneuroim.2018.03.007
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478