OBJECTIVE: To use clinical specimens to better understand the neuropathogenesis of prospective memory (ProM) functioning in persons with HIV-1 infection. BACKGROUND: Emergent evidence suggests that HIV-1 is associated with impaired ProM, but the underlying neuropathophysiology of this deficit is not known. METHODS: Thirty-five nondemented subjects with HIV-1 infection completed measures of both ProM (ie, memory for future intentions) and retrospective memory (RM; ie, memory for past episodes). A panel of biomarkers reflecting several possible neuropathogenic mechanisms of HIV was measured in plasma and cerebrospinal fluid, including HIV-1 RNA, total tau, monocyte chemoattractant protein-1 (MCP-1), soluble receptor for tumor necrosis factor type II, and fibroblast growth factor 1. RESULTS: After controlling for antiretroviral therapy and CD4 lymphocyte count, higher levels of MCP-1 in plasma, and soluble receptor for tumor necrosis factor type II and tau in cerebrospinal fluid were associated with ProM, but not RM. Markers of astrocytosis, growth factor depletion, and HIV-1 replication did not predict either ProM or RM. CONCLUSIONS: ProM impairment in HIV-1 may be dissociable from RM, perhaps reflecting specific neuropathogenic mechanisms of macrophage activation and axonal injury.
OBJECTIVE: To use clinical specimens to better understand the neuropathogenesis of prospective memory (ProM) functioning in persons with HIV-1 infection. BACKGROUND: Emergent evidence suggests that HIV-1 is associated with impaired ProM, but the underlying neuropathophysiology of this deficit is not known. METHODS: Thirty-five nondemented subjects with HIV-1 infection completed measures of both ProM (ie, memory for future intentions) and retrospective memory (RM; ie, memory for past episodes). A panel of biomarkers reflecting several possible neuropathogenic mechanisms of HIV was measured in plasma and cerebrospinal fluid, including HIV-1 RNA, total tau, monocyte chemoattractant protein-1 (MCP-1), soluble receptor for tumornecrosis factor type II, and fibroblast growth factor 1. RESULTS: After controlling for antiretroviral therapy and CD4 lymphocyte count, higher levels of MCP-1 in plasma, and soluble receptor for tumornecrosis factor type II and tau in cerebrospinal fluid were associated with ProM, but not RM. Markers of astrocytosis, growth factor depletion, and HIV-1 replication did not predict either ProM or RM. CONCLUSIONS: ProM impairment in HIV-1 may be dissociable from RM, perhaps reflecting specific neuropathogenic mechanisms of macrophage activation and axonal injury.
Authors: Catherine L Carey; Steven Paul Woods; Julie D Rippeth; Robert K Heaton; Igor Grant Journal: J Clin Exp Neuropsychol Date: 2006-05 Impact factor: 2.475
Authors: K Conant; A Garzino-Demo; A Nath; J C McArthur; W Halliday; C Power; R C Gallo; E O Major Journal: Proc Natl Acad Sci U S A Date: 1998-03-17 Impact factor: 11.205
Authors: Adriana S A Andrade; Henraya F McGruder; Albert W Wu; Shivaun A Celano; Richard L Skolasky; Ola A Selnes; I-Chan Huang; Justin C McArthur Journal: Clin Infect Dis Date: 2005-08-05 Impact factor: 9.079
Authors: P Portegies; M H Godfried; R Q Hintzen; J Stam; T van der Poll; M Bakker; S J van Deventer; R A van Lier; J Goudsmit Journal: J Neuroimmunol Date: 1993 Nov-Dec Impact factor: 3.478
Authors: Saurabh Gupta; Steven Paul Woods; Erica Weber; Matthew S Dawson; Igor Grant Journal: J Clin Exp Neuropsychol Date: 2010-04-27 Impact factor: 2.475
Authors: Sarah A Raskin; Steven Paul Woods; Amelia J Poquette; April B McTaggart; Jim Sethna; Rebecca C Williams; Alexander I Tröster Journal: Neuropsychology Date: 2011-03 Impact factor: 3.295
Authors: Steven Paul Woods; Catherine L Carey; Lisa M Moran; Matthew S Dawson; Scott L Letendre; Igor Grant Journal: Arch Clin Neuropsychol Date: 2007-02-06 Impact factor: 2.813
Authors: Steven Paul Woods; Elizabeth W Twamley; Matthew S Dawson; Jenille M Narvaez; Dilip V Jeste Journal: Schizophr Res Date: 2006-12-15 Impact factor: 4.939
Authors: David P Sheppard; Erica Weber; Kaitlin B Casaletto; Gunes Avci; Steven Paul Woods Journal: J Assoc Nurses AIDS Care Date: 2016-04-06 Impact factor: 1.354
Authors: Gunes Avci; David P Sheppard; Savanna M Tierney; Victoria M Kordovski; Kelli L Sullivan; Steven Paul Woods Journal: Clin Neuropsychol Date: 2017-09-27 Impact factor: 3.535