Joey C Prisnie1, Tolulope T Sajobi2, Meng Wang2, Scott B Patten3, Kirsten M Fiest4, Andrew G M Bulloch3, Tamara Pringsheim5, Samuel Wiebe5, Nathalie Jette6. 1. Department of Clinical Neurosciences, University of Calgary, Canada; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Canada. 2. Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Canada; Department of Community Health Sciences and O'Brien Institute for Public Health, Cumming School of Medicine, University of Calgary, Canada. 3. Department of Community Health Sciences and O'Brien Institute for Public Health, Cumming School of Medicine, University of Calgary, Canada; Department of Psychiatry and Mathison Centre for Mental Health Research, University of Calgary, Canada. 4. Department of Community Health Sciences and O'Brien Institute for Public Health, Cumming School of Medicine, University of Calgary, Canada; Department of Critical Care Medicine, University of Calgary, Canada. 5. Department of Clinical Neurosciences, University of Calgary, Canada; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Canada; Department of Community Health Sciences and O'Brien Institute for Public Health, Cumming School of Medicine, University of Calgary, Canada. 6. Department of Clinical Neurosciences, University of Calgary, Canada; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Canada; Department of Community Health Sciences and O'Brien Institute for Public Health, Cumming School of Medicine, University of Calgary, Canada; Department of Neurology, Icahn School of Medicine at Mount Sinai, United States. Electronic address: nathalie.jette@mssm.edu.
Abstract
BACKGROUND: It is unclear whether anxiety and depression impact health-related quality of life (HRQoL) equally across neurological diseases. This study examines the association between anxiety or depression and HRQoL in select neurological disorders. METHODS: HRQoL was measured using the Short Form Health Survey (SF-12) in neurological patients: epilepsy (n = 279), migraine (n = 268), multiple sclerosis (MS) (n = 222), stroke (n = 204), and Parkinson's disease (PD) (n = 224). Depression and anxiety symptoms were assessed using the Patient Health Questionnaire (PHQ-9) and Hospital Anxiety and Depression Scale (HADS-A), respectively. Multiple linear regression was used to evaluate variables associated with the SF-12 mental health component (MCS) and physical health component scores (PCS). Pratt index was used to estimate the relative importance of anxiety and depression on HRQoL. RESULTS: Anxiety and depression had the largest contribution to PCS in stroke and to MCS in epilepsy. Overall, anxiety and depression had a larger contribution to MCS as compared to PCS, except in stroke patients. Different patterns were seen across neurological diseases, with mental health variables strongly affecting MCS in all conditions, with also a sizable contribution to PCS in migraine, MS, and stroke. CONCLUSIONS: Anxiety and depression have varying impacts on HRQoL across neurological diseases. It is important for clinicians to be aware of how these patterns differ in each condition.
BACKGROUND: It is unclear whether anxiety and depression impact health-related quality of life (HRQoL) equally across neurological diseases. This study examines the association between anxiety or depression and HRQoL in select neurological disorders. METHODS: HRQoL was measured using the Short Form Health Survey (SF-12) in neurologicalpatients: epilepsy (n = 279), migraine (n = 268), multiple sclerosis (MS) (n = 222), stroke (n = 204), and Parkinson's disease (PD) (n = 224). Depression and anxiety symptoms were assessed using the Patient Health Questionnaire (PHQ-9) and Hospital Anxiety and Depression Scale (HADS-A), respectively. Multiple linear regression was used to evaluate variables associated with the SF-12 mental health component (MCS) and physical health component scores (PCS). Pratt index was used to estimate the relative importance of anxiety and depression on HRQoL. RESULTS:Anxiety and depression had the largest contribution to PCS in stroke and to MCS in epilepsy. Overall, anxiety and depression had a larger contribution to MCS as compared to PCS, except in strokepatients. Different patterns were seen across neurological diseases, with mental health variables strongly affecting MCS in all conditions, with also a sizable contribution to PCS in migraine, MS, and stroke. CONCLUSIONS:Anxiety and depression have varying impacts on HRQoL across neurological diseases. It is important for clinicians to be aware of how these patterns differ in each condition.
Authors: Anthony L Vaccarino; Derek Beaton; Sandra E Black; Pierre Blier; Farnak Farzan; Elizabeth Finger; Jane A Foster; Morris Freedman; Benicio N Frey; Susan Gilbert Evans; Keith Ho; Mojib Javadi; Sidney H Kennedy; Raymond W Lam; Anthony E Lang; Bianca Lasalandra; Sara Latour; Mario Masellis; Roumen V Milev; Daniel J Müller; Douglas P Munoz; Sagar V Parikh; Franca Placenza; Susan Rotzinger; Claudio N Soares; Alana Sparks; Stephen C Strother; Richard H Swartz; Brian Tan; Maria Carmela Tartaglia; Valerie H Taylor; Elizabeth Theriault; Gustavo Turecki; Rudolf Uher; Lorne Zinman; Kenneth R Evans Journal: Front Psychiatry Date: 2022-02-07 Impact factor: 4.157