Daniel Clark1, Yogalakshmi Rajendran1, Sarmad Paydar1, Sunita Ho2, Darren Cox3, Mark Ryder1, John Dollard1, Richard T Kao1,4. 1. Department of Orofacial Sciences, Division of Periodontology, University of California San Francisco, San Francisco, CA. 2. Department of Preventive and Restorative Dental Sciences , Division of Biomaterials and Bioengineering University of California San Francisco, San Francisco, CA. 3. Arthur A. Dugoni School of Dentistry, University of the Pacific, San Francisco, CA. 4. Private Practice , Cupertino , CA.
Abstract
BACKGROUND:Advanced platelet-rich fibrin (A-PRF) is an autogenous blood product with applications in dento-alveolar surgery. However, there is minimal information regarding its optimal clinical application or efficacy. The aim of this multi-arm parallel randomized controlled clinical trial was to evaluate the efficacy of A-PRF alone or with freeze-dried bone allograft (FDBA) in improving vital bone formation and alveolar dimensional stability during ridge preservation. METHODS:Forty patients requiring extraction of non-molar teeth and replacement with dental implants were randomized into one of four ridge preservation approaches: A-PRF, A-PRF+FDBA, FDBA, or blood clot. A-PRF was prepared at 1,300 rpm for 8 minutes. Non-traumatic extractions and ridge preservation was performed. After an average of 15 weeks healing, bone core samples were harvested at the time of implant placement for micro-CT and histomorphometric analysis. Ridge dimensions were measured immediately after extraction and before implant placement. RESULTS: Significantly greater loss of ridge height was noted in the blood clot group (3.8 ± 2.0 mm) compared to A-PRF (1.8 ± 2.1 mm) and A-PRF+FDBA (1.0 ± 2.3 mm) groups (P < 0.05). No significant differences in ridge width reduction were noted between groups. Significantly more vital bone was present in the A-PRF group (46% ± 18%) compared to the FDBA group (29% ± 14%) (P < 0.05). Bone mineral density was significantly greater in the FDBA group (551 ± 58 mg/cm3 ) compared to blood clot (487 ± 64 mg/cm3 ) (P < 0.05). CONCLUSIONS: This study demonstrates A-PRF alone or augmented with FDBA is a suitable biomaterial for ridge preservation. This study represents the first randomized controlled clinical trial comparing A-PRF with and without FDBA to FDBA alone for ridge preservation.
RCT Entities:
BACKGROUND: Advanced platelet-rich fibrin (A-PRF) is an autogenous blood product with applications in dento-alveolar surgery. However, there is minimal information regarding its optimal clinical application or efficacy. The aim of this multi-arm parallel randomized controlled clinical trial was to evaluate the efficacy of A-PRF alone or with freeze-dried bone allograft (FDBA) in improving vital bone formation and alveolar dimensional stability during ridge preservation. METHODS: Forty patients requiring extraction of non-molar teeth and replacement with dental implants were randomized into one of four ridge preservation approaches: A-PRF, A-PRF+FDBA, FDBA, or blood clot. A-PRF was prepared at 1,300 rpm for 8 minutes. Non-traumatic extractions and ridge preservation was performed. After an average of 15 weeks healing, bone core samples were harvested at the time of implant placement for micro-CT and histomorphometric analysis. Ridge dimensions were measured immediately after extraction and before implant placement. RESULTS: Significantly greater loss of ridge height was noted in the blood clot group (3.8 ± 2.0 mm) compared to A-PRF (1.8 ± 2.1 mm) and A-PRF+FDBA (1.0 ± 2.3 mm) groups (P < 0.05). No significant differences in ridge width reduction were noted between groups. Significantly more vital bone was present in the A-PRF group (46% ± 18%) compared to the FDBA group (29% ± 14%) (P < 0.05). Bone mineral density was significantly greater in the FDBA group (551 ± 58 mg/cm3 ) compared to blood clot (487 ± 64 mg/cm3 ) (P < 0.05). CONCLUSIONS: This study demonstrates A-PRF alone or augmented with FDBA is a suitable biomaterial for ridge preservation. This study represents the first randomized controlled clinical trial comparing A-PRF with and without FDBA to FDBA alone for ridge preservation.
Authors: David M Dohan; Joseph Choukroun; Antoine Diss; Steve L Dohan; Anthony J J Dohan; Jaafar Mouhyi; Bruno Gogly Journal: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Date: 2006-01-10
Authors: David M Dohan; Joseph Choukroun; Antoine Diss; Steve L Dohan; Anthony J J Dohan; Jaafar Mouhyi; Bruno Gogly Journal: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Date: 2006-01-19
Authors: Shahram Ghanaati; Patrick Booms; Anna Orlowska; Alica Kubesch; Jonas Lorenz; Jim Rutkowski; Constantin Landes; Robert Sader; Cj Kirkpatrick; Joseph Choukroun Journal: J Oral Implantol Date: 2014-12 Impact factor: 1.779
Authors: John M Iasella; Henry Greenwell; Richard L Miller; Margaret Hill; Connie Drisko; Aziz A Bohra; James P Scheetz Journal: J Periodontol Date: 2003-07 Impact factor: 6.993
Authors: Marco Tatullo; Massimo Marrelli; Michele Cassetta; Andrea Pacifici; Luigi Vito Stefanelli; Salvatore Scacco; Gianna Dipalma; Luciano Pacifici; Francesco Inchingolo Journal: Int J Med Sci Date: 2012-11-07 Impact factor: 3.738
Authors: L Canullo; M Del Fabbro; S Khijmatgar; S Panda; A Ravidà; G Tommasato; A Sculean; P Pesce Journal: Clin Oral Investig Date: 2021-11-26 Impact factor: 3.606
Authors: Momen A Atieh; Nabeel Hm Alsabeeha; Alan Gt Payne; Sara Ali; Clovis M Jr Faggion; Marco Esposito Journal: Cochrane Database Syst Rev Date: 2021-04-26