Ranjit Unnikrishnan1, Prasanna Kumar Gupta1, Viswanathan Mohan2. 1. Department of Diabetology, Dr. Mohan's Diabetes Specialities Centre & Madras Diabetes Research Foundation, ICMR Centre for Advanced Research on Diabetes, WHO Collaborating Centre, Non-Communicable Disease Prevention & Control & IDF Centre of Excellence in Diabetes Care, No 4, Conran Smith Road, Gopalapuram, Chennai, 600 086, India. 2. Department of Diabetology, Dr. Mohan's Diabetes Specialities Centre & Madras Diabetes Research Foundation, ICMR Centre for Advanced Research on Diabetes, WHO Collaborating Centre, Non-Communicable Disease Prevention & Control & IDF Centre of Excellence in Diabetes Care, No 4, Conran Smith Road, Gopalapuram, Chennai, 600 086, India. drmohans@diabetes.ind.in.
Abstract
PURPOSE OF REVIEW: South Asia is one of the epicenters of the global diabetes pandemic. Diabetes in south Asians has certain peculiar features with respect to its pathophysiology, clinical presentation, and management. This review aims to summarize some of the recent evidence pertaining to the distinct diabetes phenotype in south Asians. RECENT FINDINGS: South Asia has high incidence and prevalence rates of diabetes. The progression from "pre-diabetes" to diabetes also occurs faster in this population. Pancreatic beta cell dysfunction seems to be as important as insulin resistance in the pathophysiology of diabetes in south Asians. Recent evidence suggests that the epidemic of diabetes in south Asia is spreading to rural areas and to less affluent sections of society. Diabetes in south Asians differs significantly from that in white Caucasians, with important implications for prevention, diagnosis, and management.
PURPOSE OF REVIEW: South Asia is one of the epicenters of the global diabetes pandemic. Diabetes in south Asians has certain peculiar features with respect to its pathophysiology, clinical presentation, and management. This review aims to summarize some of the recent evidence pertaining to the distinct diabetes phenotype in south Asians. RECENT FINDINGS: South Asia has high incidence and prevalence rates of diabetes. The progression from "pre-diabetes" to diabetes also occurs faster in this population. Pancreatic beta cell dysfunction seems to be as important as insulin resistance in the pathophysiology of diabetes in south Asians. Recent evidence suggests that the epidemic of diabetes in south Asia is spreading to rural areas and to less affluent sections of society. Diabetes in south Asians differs significantly from that in white Caucasians, with important implications for prevention, diagnosis, and management.
Entities:
Keywords:
Diabetes; Incidence; Phenotype; Pre-diabetes; Prevalence; South Asians
Authors: C S Yajnik; H G Lubree; S S Rege; S S Naik; J A Deshpande; S S Deshpande; C V Joglekar; J S Yudkin Journal: J Clin Endocrinol Metab Date: 2002-12 Impact factor: 5.958
Authors: R M Anjana; R Pradeepa; M Deepa; M Datta; V Sudha; R Unnikrishnan; A Bhansali; S R Joshi; P P Joshi; C S Yajnik; V K Dhandhania; L M Nath; A K Das; P V Rao; S V Madhu; D K Shukla; T Kaur; M Priya; E Nirmal; S J Parvathi; S Subhashini; R Subashini; M K Ali; V Mohan Journal: Diabetologia Date: 2011-09-30 Impact factor: 10.122
Authors: X R Pan; G W Li; Y H Hu; J X Wang; W Y Yang; Z X An; Z X Hu; J Lin; J Z Xiao; H B Cao; P A Liu; X G Jiang; Y Y Jiang; J P Wang; H Zheng; H Zhang; P H Bennett; B V Howard Journal: Diabetes Care Date: 1997-04 Impact factor: 19.112
Authors: Satoyo Ikehara; Adam G Tabák; Tasnime N Akbaraly; Adam Hulmán; Mika Kivimäki; Nita G Forouhi; Hiroyasu Iso; Eric J Brunner Journal: Diabetologia Date: 2014-11-28 Impact factor: 10.122
Authors: Lisa R Staimez; Mary Beth Weber; Harish Ranjani; Mohammed K Ali; Justin B Echouffo-Tcheugui; Lawrence S Phillips; Viswanathan Mohan; K M Venkat Narayan Journal: Diabetes Care Date: 2013-04-17 Impact factor: 19.112
Authors: J Jaime Miranda; Tonatiuh Barrientos-Gutiérrez; Camila Corvalan; Adnan A Hyder; Maria Lazo-Porras; Tolu Oni; Jonathan C K Wells Journal: Nat Med Date: 2019-11-07 Impact factor: 53.440
Authors: Sushrima Gan; Adem Y Dawed; Louise A Donnelly; Anand T N Nair; Colin N A Palmer; Viswanathan Mohan; Ewan R Pearson Journal: Diabetes Care Date: 2020-08 Impact factor: 19.112
Authors: Miyang Luo; Linda Wei Lin Tan; Xueling Sim; Milly Khiam Hoon Ng; Rob Van Dam; E Shyong Tai; Kee Seng Chia; Wern Ee Tang; Darren Ej Seah; Kavita Venkataraman Journal: BMJ Open Date: 2020-05-30 Impact factor: 2.692
Authors: Viswanathan Mohan; Kamlesh Khunti; Siew P Chan; Fadlo F Filho; Nam Q Tran; Kaushik Ramaiya; Shashank Joshi; Ambrish Mithal; Maïmouna N Mbaye; Nemencio A Nicodemus; Tint S Latt; Linong Ji; Ibrahim N Elebrashy; Jean C Mbanya Journal: Diabetes Ther Date: 2019-11-26 Impact factor: 2.945