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Literature DB >> 29670694

Study on Liposomal Encapsulation of New Bodipy Sensitizers for Photodynamic Therapy.

Thumuganti Gayathri^1,2, A Vijayalakshmi³, Sreejith Mangalath⁴, Joshy Joseph⁴, N Madhusudhana Rao³, Surya Prakash Singh^1,2.

Abstract

We report a series of four efficient photosensitizers (PSs) based on a Bodipy core for photodynamic therapy (PDT). In the absence of hydrophilic functional groups, these PSs have been encapsulated in liposomes and examined for photocytotoxicity against human ovarian carcinoma cell line (SK-OV-3). The IC50 values obtained are as low as 0.350 μM, which compete with the classical photosensitizer chlorine E6 (IC50 = 0.39 μM) under similar experimental conditions.

Entities: Chemical Disease Species

Year: 2018 PMID： 29670694 PMCID： PMC5900332 DOI： 10.1021/acsmedchemlett.7b00490

Source DB: PubMed Journal: ACS Med Chem Lett ISSN： 1948-5875 Impact factor: 4.345

28 in total

Review 1. Photodynamic therapy in head and neck cancer.

Authors: Merrill A Biel
Journal: Curr Oncol Rep Date: 2002-01 Impact factor: 5.075

Review 2. Liposomes and niosomes as topical drug delivery systems.

Authors: M J Choi; H I Maibach
Journal: Skin Pharmacol Physiol Date: 2005-07-05 Impact factor: 3.479

3. Bright, color-tunable fluorescent dyes in the visible-near-infrared region.

Authors: Keitaro Umezawa; Yuki Nakamura; Hiroshi Makino; Daniel Citterio; Koji Suzuki
Journal: J Am Chem Soc Date: 2008-01-15 Impact factor: 15.419

Review 4. Liposomes in topical photodynamic therapy.

Authors: Nina Dragicevic-Curic; Alfred Fahr
Journal: Expert Opin Drug Deliv Date: 2012-06-25 Impact factor: 6.648

5. Synthesis and in vitro photodynamic activities of pegylated distyryl boron dipyrromethene derivatives.

Authors: Hui He; Pui-Chi Lo; Sin-Lui Yeung; Wing-Ping Fong; Dennis K P Ng
Journal: J Med Chem Date: 2011-03-21 Impact factor: 7.446

6. In vitro and in vivo photocytotoxicity of boron dipyrromethene derivatives for photodynamic therapy.

Authors: Siang Hui Lim; Cliferson Thivierge; Patrycja Nowak-Sliwinska; Junyan Han; Hubert van den Bergh; Georges Wagnières; Kevin Burgess; Hong Boon Lee
Journal: J Med Chem Date: 2010-04-08 Impact factor: 7.446

7. Preparation of unsymmetrical distyryl BODIPY derivatives and effects of the styryl substituents on their in vitro photodynamic properties.

Authors: Hui He; Pui-Chi Lo; Sin-Lui Yeung; Wing-Ping Fong; Dennis K P Ng
Journal: Chem Commun (Camb) Date: 2011-03-15 Impact factor: 6.222

8. A new fluorescence method to detect singlet oxygen inside phospholipid model membranes.

Authors: M Wozniak; F Tanfani; E Bertoli; G Zolese; J Antosiewicz
Journal: Biochim Biophys Acta Date: 1991-02-26

9. Thienopyrrole-expanded BODIPY as a potential NIR photosensitizer for photodynamic therapy.

Authors: Yongchao Yang; Qiuli Guo; Huachao Chen; Zhikuan Zhou; Zijian Guo; Zhen Shen
Journal: Chem Commun (Camb) Date: 2013-03-27 Impact factor: 6.222

10. Bright, color-tunable fluorescent dyes in the Vis/NIR region: establishment of new "tailor-made" multicolor fluorophores based on borondipyrromethene.

Authors: Keitaro Umezawa; Akihiro Matsui; Yuki Nakamura; Daniel Citterio; Koji Suzuki
Journal: Chemistry Date: 2009 Impact factor: 5.236

3 in total