Isaak Fischinger1,2,3, Theo G Seiler4,5,6, Karthiga Santhirasegaram4, Moritz Pettenkofer4, Chris P Lohmann4, Daniel Zapp4. 1. The Klinik und Poliklinik für Augenheilkunde, Klinikum rechts der Isar, Technische Universität München, Ismaningerstraße 21, 81675, Munich, Germany. isaak.fischinger@hotmail.com. 2. The Institut für Refraktive und Ophthalmo-Chirurgie (IROC), Zürich, Switzerland. isaak.fischinger@hotmail.com. 3. The Inselspital Bern, Universitätsspital Bern, Bern, Switzerland. isaak.fischinger@hotmail.com. 4. The Klinik und Poliklinik für Augenheilkunde, Klinikum rechts der Isar, Technische Universität München, Ismaningerstraße 21, 81675, Munich, Germany. 5. The Institut für Refraktive und Ophthalmo-Chirurgie (IROC), Zürich, Switzerland. 6. The Inselspital Bern, Universitätsspital Bern, Bern, Switzerland.
Abstract
PURPOSE: To investigate safety of accelerated corneal crosslinking during the first postoperative month. METHODS: In this retrospective study, 76 eyes of 60 patients with verified progressive keratectasia were enrolled in this study and followed for 1 month after accelerated CXL (18 mW/cm2 for 5 min, radiant exposure 5.4 J/cm2) (A-CXL(5*18)). Preoperatively, objective refraction, slit lamp inspection, and corneal tomography were performed. Early postoperative slit lamp examinations were performed on days 1 and 4. At 1 month, objective refraction, slit lamp inspection, and corneal tomography were performed. RESULTS: Gender distribution was m:f = 55:21, OD:OS was 40:36, and the average age was 26.5 ± 8.6 years at surgery. Only 71 of the 76 eyes completed the 1-month follow-up, indicating a dropout rate of 6.6%. In 7.0% (n = 5), sterile infiltrates were observed; 5.6% of eyes (n = 4) showed delayed epithelial healing (> 4 days) in 2.8% (n = 2); an infection occurred and in 1 eye (1.4%), a stromal scar was detected; no other complications, neither a loss of two or more Snellen lines at 1 month postoperatively, were observed. As a risk factor for sterile infiltrates, thin preoperative pachymetry could be identified (p = 0.027). CONCLUSIONS: This study revealed no difference in early postoperative safety between CXL using 18 mW/cm2 and standard corneal CXL. Thinner preoperative pachymetry could be identified predicting a higher rate of postoperative sterile infiltrates.
PURPOSE: To investigate safety of accelerated corneal crosslinking during the first postoperative month. METHODS: In this retrospective study, 76 eyes of 60 patients with verified progressive keratectasia were enrolled in this study and followed for 1 month after accelerated CXL (18 mW/cm2 for 5 min, radiant exposure 5.4 J/cm2) (A-CXL(5*18)). Preoperatively, objective refraction, slit lamp inspection, and corneal tomography were performed. Early postoperative slit lamp examinations were performed on days 1 and 4. At 1 month, objective refraction, slit lamp inspection, and corneal tomography were performed. RESULTS: Gender distribution was m:f = 55:21, OD:OS was 40:36, and the average age was 26.5 ± 8.6 years at surgery. Only 71 of the 76 eyes completed the 1-month follow-up, indicating a dropout rate of 6.6%. In 7.0% (n = 5), sterile infiltrates were observed; 5.6% of eyes (n = 4) showed delayed epithelial healing (> 4 days) in 2.8% (n = 2); an infection occurred and in 1 eye (1.4%), a stromal scar was detected; no other complications, neither a loss of two or more Snellen lines at 1 month postoperatively, were observed. As a risk factor for sterile infiltrates, thin preoperative pachymetry could be identified (p = 0.027). CONCLUSIONS: This study revealed no difference in early postoperative safety between CXL using 18 mW/cm2 and standard corneal CXL. Thinner preoperative pachymetry could be identified predicting a higher rate of postoperative sterile infiltrates.
Authors: Theo G Seiler; Isaak Fischinger; Tim Senfft; Gerald Schmidinger; Theo Seiler Journal: Invest Ophthalmol Vis Sci Date: 2014-06-10 Impact factor: 4.799
Authors: George D Kymionis; Michael A Grentzelos; Vardhaman P Kankariya; Dimitrios A Liakopoulos; Dimitra M Portaliou; Konstantinos I Tsoulnaras; Alexandra E Karavitaki; Aristophanis I Pallikaris Journal: J Cataract Refract Surg Date: 2014-08 Impact factor: 3.351