Literature DB >> 29664486

Heparin-induced tau filaments are structurally heterogeneous and differ from Alzheimer's disease filaments.

Yann Fichou1, Michael Vigers, Andrew K Goring, Neil A Eschmann, Songi Han.   

Abstract

Alzheimer's disease (AD) is characterized by the presence of tau filaments in the brain whose structure was recently solved. The formation of AD filaments is routinely modeled in vitro by mixing tau with heparin. This study shows that heparin-induced tau filaments are markedly different from the AD filaments and are highly heterogeneous.

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Year:  2018        PMID： 29664486     DOI： 10.1039/c8cc01355a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  20 in total

1.  Cofactors are essential constituents of stable and seeding-active tau fibrils.

Authors:  Yann Fichou; Yanxian Lin; Jennifer N Rauch; Michael Vigers; Zhikai Zeng; Madhur Srivastava; Timothy J Keller; Jack H Freed; Kenneth S Kosik; Songi Han
Journal:  Proc Natl Acad Sci U S A       Date:  2018-12-11       Impact factor: 11.205

2.  In vitro 0N4R tau fibrils contain a monomorphic β-sheet core enclosed by dynamically heterogeneous fuzzy coat segments.

Authors:  Aurelio J Dregni; Venkata S Mandala; Haifan Wu; Matthew R Elkins; Harrison K Wang; Ivan Hung; William F DeGrado; Mei Hong
Journal:  Proc Natl Acad Sci U S A       Date:  2019-07-29       Impact factor: 11.205

3.  In vitro Tau Aggregation Inducer Molecules Influence the Effects of MAPT Mutations on Aggregation Dynamics.

Authors:  David J Ingham; Kelsey M Hillyer; Madison J McGuire; Truman C Gamblin
Journal:  Biochemistry       Date:  2022-06-22       Impact factor: 3.321

4.  Specific Peptide from the Novel W-Tau Isoform Inhibits Tau and Amyloid β Peptide Aggregation In Vitro.

Authors:  Raquel Cuadros; Mar Pérez; Daniel Ruiz-Gabarre; Félix Hernández; Vega García-Escudero; Jesús Avila
Journal:  ACS Chem Neurosci       Date:  2022-06-13       Impact factor: 5.780

5.  Structural disorder in four-repeat Tau fibrils reveals a new mechanism for barriers to cross-seeding of Tau isoforms.

Authors:  Hilary A Weismiller; Rachel Murphy; Guanghong Wei; Buyong Ma; Ruth Nussinov; Martin Margittai
Journal:  J Biol Chem       Date:  2018-09-21       Impact factor: 5.157

6.  Impaired tau-microtubule interactions are prevalent among pathogenic tau variants arising from missense mutations.

Authors:  Yuxing Xia; Zachary A Sorrentino; Justin D Kim; Kevin H Strang; Cara J Riffe; Benoit I Giasson
Journal:  J Biol Chem       Date:  2019-10-24       Impact factor: 5.157

Review 7.  Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer's Disease, Parkinson's Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis.

Authors:  Phuong H Nguyen; Ayyalusamy Ramamoorthy; Bikash R Sahoo; Jie Zheng; Peter Faller; John E Straub; Laura Dominguez; Joan-Emma Shea; Nikolay V Dokholyan; Alfonso De Simone; Buyong Ma; Ruth Nussinov; Saeed Najafi; Son Tung Ngo; Antoine Loquet; Mara Chiricotto; Pritam Ganguly; James McCarty; Mai Suan Li; Carol Hall; Yiming Wang; Yifat Miller; Simone Melchionna; Birgit Habenstein; Stepan Timr; Jiaxing Chen; Brianna Hnath; Birgit Strodel; Rakez Kayed; Sylvain Lesné; Guanghong Wei; Fabio Sterpone; Andrew J Doig; Philippe Derreumaux
Journal:  Chem Rev       Date:  2021-02-05       Impact factor: 60.622

8.  Fungally Derived Isoquinoline Demonstrates Inducer-Specific Tau Aggregation Inhibition.

Authors:  David J Ingham; Bryce R Blankenfeld; Shibin Chacko; Chamani Perera; Berl R Oakley; Truman Christopher Gamblin
Journal:  Biochemistry       Date:  2021-05-19       Impact factor: 3.162

9.  Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases.

Authors:  Wenjuan Zhang; Benjamin Falcon; Alexey G Murzin; Juan Fan; R Anthony Crowther; Michel Goedert; Sjors Hw Scheres
Journal:  Elife       Date:  2019-02-05       Impact factor: 8.140

10.  Phosphorylation and O-GlcNAcylation of the PHF-1 Epitope of Tau Protein Induce Local Conformational Changes of the C-Terminus and Modulate Tau Self-Assembly Into Fibrillar Aggregates.

Authors:  François-Xavier Cantrelle; Anne Loyens; Xavier Trivelli; Oliver Reimann; Clément Despres; Neha S Gandhi; Christian P R Hackenberger; Isabelle Landrieu; Caroline Smet-Nocca
Journal:  Front Mol Neurosci       Date:  2021-06-17       Impact factor: 5.639
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