Guoqing Wang1, Xiaoyang Zhang1, Mengzhao Feng1, Fuyou Guo2. 1. Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, ZhengZhou, HeNan Province, PR China. 2. Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, ZhengZhou, HeNan Province, PR China; Department of Neurosurgery, Key Laboratory of Neurosurgical Diseases, The First Affiliated Hospital of Zhengzhou University, ZhengZhou, HeNan Province, PR China. Electronic address: chyou666@hotmail.com.
Abstract
BACKGROUND: Recent studies suggest that subtotal resection (STR) followed by radiation therapy (RT) is an appealing alternative to gross total resection (GTR) for craniopharyngioma, but it remains controversial. We conducted a meta-analysis to determine whether GTR is superior to STR with RT for craniopharyngioma. MATERIALS AND METHODS: A systematic search was performed for articles published until October 2017 in the PubMed, Embase, and Cochrane Central databases. The endpoints of interest are overall survival and progression-free survival. Pooled hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) were calculated using a fixed or random-effects model. The data were analyzed using Review Manager 5.3 software. RESULTS: A total of 744 patients (seven cohort studies) were enrolled for analyses. There were no significant differences between the GTR and STR with RT groups when the authors compared the pooled HRs at the end of the follow-up period. Overall survival (pooled HR = 0.76, 95% CI: 0.46-1.25, P = 0.28) and progression-free survival (pooled HR = 1.52, 95% CI: 0.42-5.44, P = 0.52) were similar between the two groups. CONCLUSIONS: The current meta-analysis suggests that GTR and STR with RT have the similar survival outcomes for craniopharyngioma.
BACKGROUND: Recent studies suggest that subtotal resection (STR) followed by radiation therapy (RT) is an appealing alternative to gross total resection (GTR) for craniopharyngioma, but it remains controversial. We conducted a meta-analysis to determine whether GTR is superior to STR with RT for craniopharyngioma. MATERIALS AND METHODS: A systematic search was performed for articles published until October 2017 in the PubMed, Embase, and Cochrane Central databases. The endpoints of interest are overall survival and progression-free survival. Pooled hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) were calculated using a fixed or random-effects model. The data were analyzed using Review Manager 5.3 software. RESULTS: A total of 744 patients (seven cohort studies) were enrolled for analyses. There were no significant differences between the GTR and STR with RT groups when the authors compared the pooled HRs at the end of the follow-up period. Overall survival (pooled HR = 0.76, 95% CI: 0.46-1.25, P = 0.28) and progression-free survival (pooled HR = 1.52, 95% CI: 0.42-5.44, P = 0.52) were similar between the two groups. CONCLUSIONS: The current meta-analysis suggests that GTR and STR with RT have the similar survival outcomes for craniopharyngioma.
Authors: Abd El Rahman Enayet; Mostafa M E Atteya; Hala Taha; Mohamed Saad Zaghloul; Amal Refaat; Eslam Maher; Amal Abdelaziz; Mohamed A El Beltagy Journal: Childs Nerv Syst Date: 2020-07-26 Impact factor: 1.475