M J Haapanen1,2, M M Perälä2,3, M K Salonen2,3, E Kajantie3,4,5, M Simonen6, P Pohjolainen7, J G Eriksson1,2,3,8, M B von Bonsdorff2,9. 1. Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. 2. Folkhälsan Research Center, Helsinki, Finland. 3. Department of Public Health Solutions, Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland. 4. Hospital for Children and Adolescents, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland. 5. PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland. 6. Finnish Centre of Excellence in Intersubjectivity and Interaction, University of Helsinki, Helsinki, Finland. 7. Age Institute, Helsinki, Finland. 8. Vaasa Central Hospital, Vaasa, Finland. 9. Gerontology Research Center, Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland.
Abstract
BACKGROUND: there is evidence suggesting that several chronic diseases have their origins in utero and that development taking place during sensitive periods may affect the aging process. We investigated whether early life determinants would be associated with frailty in old age. METHODS: at a mean age of 71 years, 1,078 participants belonging to the Helsinki Birth Cohort Study were assessed for frailty according to the Fried frailty criteria. Early life measurements (birth weight, length, mother body mass index [BMI] and parity) were obtained from birth, child welfare and school health records. Multinomial regression analysis was used to assess the association between early life determinants and frailty in old age. RESULTS: weight, length and BMI at birth were all inversely associated with frailty in old age. A 1 kg increase in birth weight was associated with a lower relative risk ratio (RRR) of frailty (age and sex-adjusted RRR = 0.40, 95% CI: 0.19, 0.82) compared to non-frailty. Associations persisted after adjusting for several confounding factors. Compared to cohort members in the upper middle class, those who as adults worked as manual workers or belonged to the lower middle class, were at an increased risk of frailty. CONCLUSIONS: those who were small at birth were at an increased risk of developing frailty in old age, suggesting that frailty is at least partly programmed in early life. A less privileged socioeconomic status in adulthood was associated with an increased risk of frailty in old age.
BACKGROUND: there is evidence suggesting that several chronic diseases have their origins in utero and that development taking place during sensitive periods may affect the aging process. We investigated whether early life determinants would be associated with frailty in old age. METHODS: at a mean age of 71 years, 1,078 participants belonging to the Helsinki Birth Cohort Study were assessed for frailty according to the Fried frailty criteria. Early life measurements (birth weight, length, mother body mass index [BMI] and parity) were obtained from birth, child welfare and school health records. Multinomial regression analysis was used to assess the association between early life determinants and frailty in old age. RESULTS: weight, length and BMI at birth were all inversely associated with frailty in old age. A 1 kg increase in birth weight was associated with a lower relative risk ratio (RRR) of frailty (age and sex-adjusted RRR = 0.40, 95% CI: 0.19, 0.82) compared to non-frailty. Associations persisted after adjusting for several confounding factors. Compared to cohort members in the upper middle class, those who as adults worked as manual workers or belonged to the lower middle class, were at an increased risk of frailty. CONCLUSIONS: those who were small at birth were at an increased risk of developing frailty in old age, suggesting that frailty is at least partly programmed in early life. A less privileged socioeconomic status in adulthood was associated with an increased risk of frailty in old age.
Authors: M J Haapanen; M M Perälä; C Osmond; M K Salonen; E Kajantie; T Rantanen; M Simonen; P Pohjolainen; J G Eriksson; M B von Bonsdorff Journal: Aging Clin Exp Res Date: 2018-07-24 Impact factor: 3.636
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Authors: M J Haapanen; M M Perälä; M K Salonen; E Kajantie; M Simonen; P Pohjolainen; A K Pesonen; K Räikkönen; J G Eriksson; M B von Bonsdorff Journal: BMC Geriatr Date: 2018-08-13 Impact factor: 3.921
Authors: Nina T Rogers; Joanna M Blodgett; Samuel D Searle; Rachel Cooper; Daniel H J Davis; Snehal M Pinto Pereira Journal: Am J Epidemiol Date: 2021-08-01 Impact factor: 4.897