M J Haapanen1,2, M M Perälä3,4, C Osmond5, M K Salonen3,4, E Kajantie4,6,7, T Rantanen8, M Simonen9, P Pohjolainen10, J G Eriksson11,3,4, M B von Bonsdorff3,8. 1. Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, PO Box 20, 00014, Helsinki, Finland. markus.haapanen@helsinki.fi. 2. Folkhälsan Research Center, Helsinki, Finland. markus.haapanen@helsinki.fi. 3. Folkhälsan Research Center, Helsinki, Finland. 4. Chronic Disease Prevention Unit, Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland. 5. MRC Lifecourse Epidemiology Unit, Southampton General Hospital, University of Southamptom, Southampton, UK. 6. Hospital for Children and Adolescents, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland. 7. PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland. 8. Faculty of Sport and Health Sciences, Gerontology Research Center, University of Jyväskylä, Jyvaskyla, Finland. 9. Finnish Centre of Excellence in Intersubjectivity in Interaction, University of Helsinki, Helsinki, Finland. 10. Age Institute, Helsinki, Finland. 11. Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, PO Box 20, 00014, Helsinki, Finland.
Abstract
BACKGROUND: Evidence from life course studies highlights the importance of infant and childhood growth as risk factors for adulthood chronic diseases. METHODS: In this sub-study of the Helsinki Birth Cohort Study, we studied 1078 individuals who had both information on body size from birth to 12 years of age and who were assessed for frailty according to the Fried criteria at the mean age of 71 years. RESULTS: Greater BMI gain between 2 and 11 years in boys was associated with frailty in old age (age-adjusted RRR 2.36, 95% CI 1.21, 4.63). No similar associations were observed in girls. CONCLUSIONS: Men who were frail in old age experienced accelerated BMI gain in childhood compared with those men who were not frail. This was not observed in women, which suggests that the patterns of early growth predisposing to frailty may vary by sex.
BACKGROUND: Evidence from life course studies highlights the importance of infant and childhood growth as risk factors for adulthood chronic diseases. METHODS: In this sub-study of the Helsinki Birth Cohort Study, we studied 1078 individuals who had both information on body size from birth to 12 years of age and who were assessed for frailty according to the Fried criteria at the mean age of 71 years. RESULTS: Greater BMI gain between 2 and 11 years in boys was associated with frailty in old age (age-adjusted RRR 2.36, 95% CI 1.21, 4.63). No similar associations were observed in girls. CONCLUSIONS:Men who were frail in old age experienced accelerated BMI gain in childhood compared with those men who were not frail. This was not observed in women, which suggests that the patterns of early growth predisposing to frailty may vary by sex.
Entities:
Keywords:
Frailty; Growth; Life course; Risk factor
Authors: Linda P Fried; Luigi Ferrucci; Jonathan Darer; Jeff D Williamson; Gerard Anderson Journal: J Gerontol A Biol Sci Med Sci Date: 2004-03 Impact factor: 6.053
Authors: Mikaela B von Bonsdorff; Taina Rantanen; Sarianna Sipilä; Minna K Salonen; Eero Kajantie; Clive Osmond; David J P Barker; Johan G Eriksson Journal: Am J Epidemiol Date: 2011-11-09 Impact factor: 4.897
Authors: Sofie Vermeiren; Roberta Vella-Azzopardi; David Beckwée; Ann-Katrin Habbig; Aldo Scafoglieri; Bart Jansen; Ivan Bautmans Journal: J Am Med Dir Assoc Date: 2016-12-01 Impact factor: 4.669
Authors: Mia-Maria Perälä; Mikaela von Bonsdorff; Satu Männistö; Minna K Salonen; Mika Simonen; Noora Kanerva; Pertti Pohjolainen; Eero Kajantie; Taina Rantanen; Johan G Eriksson Journal: Br J Nutr Date: 2016-01-20 Impact factor: 3.718