Literature DB >> 296587

Some thoughts about genetics, differentiation, and malignancy.

H Harris.   

Abstract

This article deals with three related questions: (1) whether malignancy is determined by genetic or epigenetic mechanisms; (2) whether epigenetic mechanisms, as conventionally defined, actually exist; (3) what criteria are appropriate for defining dominance or recessiveness of the malignant state in cell fusion experiments.

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Year:  1979        PMID： 296587     DOI： 10.1007/bf01542651

Source DB:  PubMed          Journal:  Somatic Cell Genet        ISSN： 0098-0366


  4 in total

1.  The majority of independently transformed BHK cell clones share a single functional lesion which determines anchorage independence and influences tumorigenicity.

Authors:  N Bouck; M Head
Journal:  In Vitro Cell Dev Biol       Date:  1985-08

Review 2.  Chemical carcinogenesis -- the price for DNA - repair?

Authors:  U Wintersberger
Journal:  Naturwissenschaften       Date:  1982-03

Review 3.  Somatic cell fusion as a source of genetic rearrangement leading to metastatic variants.

Authors:  L Larizza; V Schirrmacher
Journal:  Cancer Metastasis Rev       Date:  1984       Impact factor: 9.264

Review 4.  Mutation or not, what directly establishes a neoplastic state, namely cellular immortality and autonomy, still remains unknown and should be prioritized in our research.

Authors:  Shengming Zhu; Jiangang Wang; Lucas Zellmer; Ningzhi Xu; Mei Liu; Yun Hu; Hong Ma; Fei Deng; Wenxiu Yang; Dezhong Joshua Liao
Journal:  J Cancer       Date:  2022-07-04       Impact factor: 4.478
  4 in total

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