Literature DB >> 12521380

Gene disruption discloses role of selenoprotein P in selenium delivery to target tissues.

Lutz Schomburg1, Ulrich Schweizer, Bettina Holtmann, Leopold Flohé, Michael Sendtner, Josef Köhrle.   

Abstract

Selenoprotein P (SePP), the major selenoprotein in plasma, has been implicated in selenium transport, selenium detoxification or antioxidant defence. We generated SePP-knockout mice that were viable, but exhibited reduced growth and developed ataxia. Selenium content was elevated in liver, but low in plasma and other tissues, and selenoenzyme activities changed accordingly. Our data reveal that SePP plays a pivotal role in delivering hepatic selenium to target tissues.

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Year:  2003        PMID： 12521380      PMCID： PMC1223208          DOI： 10.1042/BJ20021853

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  32 in total

1.  Toxicity, metabolism and absorption of selenite by isolated rat hepatocytes.

Authors:  Y C Park; P D Whanger
Journal:  Toxicology       Date:  1995-06-26       Impact factor: 4.221

2.  Assays of glutathione peroxidase.

Authors:  L Flohé; W A Günzler
Journal:  Methods Enzymol       Date:  1984       Impact factor: 1.600

3.  Simplified fluorometric assay of total selenium in plasma and urine.

Authors:  T M Sheehan; M Gao
Journal:  Clin Chem       Date:  1990-12       Impact factor: 8.327

4.  Selenoprotein P receptor from rat.

Authors:  B Gomez; A L Tappel
Journal:  Biochim Biophys Acta       Date:  1989-02-13

5.  Response of rat selenoprotein P to selenium administration and fate of its selenium.

Authors:  R F Burk; K E Hill; R Read; T Bellew
Journal:  Am J Physiol       Date:  1991-07

6.  Growth and plasma triiodothyronine concentrations are modified by selenium deficiency and repletion in second-generation selenium-deficient rats.

Authors:  K M Thompson; H Haibach; R A Sunde
Journal:  J Nutr       Date:  1995-04       Impact factor: 4.798

7.  Evidence for specific selenium target tissues and new biologically important selenoproteins.

Authors:  D Behne; H Hilmert; S Scheid; H Gessner; W Elger
Journal:  Biochim Biophys Acta       Date:  1988-07-14

8.  A selenocysteine-containing selenium-transport protein in rat plasma.

Authors:  M A Motsenbocker; A L Tappel
Journal:  Biochim Biophys Acta       Date:  1982-10-28

9.  Thyroid hormones rapidly and stringently regulate the messenger RNA levels of the thyrotropin-releasing hormone (TRH) receptor and the TRH-degrading ectoenzyme.

Authors:  L Schomburg; K Bauer
Journal:  Endocrinology       Date:  1995-08       Impact factor: 4.736

10.  Tissue-specific regulation of selenoenzyme gene expression during selenium deficiency in rats.

Authors:  G Bermano; F Nicol; J A Dyer; R A Sunde; G J Beckett; J R Arthur; J E Hesketh
Journal:  Biochem J       Date:  1995-10-15       Impact factor: 3.857
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  113 in total

1.  Progression of neurodegeneration and morphologic changes in the brains of juvenile mice with selenoprotein P deleted.

Authors:  Samuel W Caito; Dejan Milatovic; Kristina E Hill; Michael Aschner; Raymond F Burk; William M Valentine
Journal:  Brain Res       Date:  2011-05-05       Impact factor: 3.252

Review 2.  Lipoprotein receptors--an evolutionarily ancient multifunctional receptor family.

Authors:  Marco Dieckmann; Martin Frederik Dietrich; Joachim Herz
Journal:  Biol Chem       Date:  2010-11       Impact factor: 3.915

3.  Deletion of selenoprotein P results in impaired function of parvalbumin interneurons and alterations in fear learning and sensorimotor gating.

Authors:  M W Pitts; A V Raman; A C Hashimoto; C Todorovic; R A Nichols; M J Berry
Journal:  Neuroscience       Date:  2012-02-21       Impact factor: 3.590

4.  Efficient incorporation of multiple selenocysteines involves an inefficient decoding step serving as a potential translational checkpoint and ribosome bottleneck.

Authors:  Zoia Stoytcheva; Rosa M Tujebajeva; John W Harney; Marla J Berry
Journal:  Mol Cell Biol       Date:  2006-09-25       Impact factor: 4.272

Review 5.  Selenoproteins and their impact on human health through diverse physiological pathways.

Authors:  Behzad Moghadaszadeh; Alan H Beggs
Journal:  Physiology (Bethesda)       Date:  2006-10

6.  Production of selenoprotein P (Sepp1) by hepatocytes is central to selenium homeostasis.

Authors:  Kristina E Hill; Sen Wu; Amy K Motley; Teri D Stevenson; Virginia P Winfrey; Mario R Capecchi; John F Atkins; Raymond F Burk
Journal:  J Biol Chem       Date:  2012-10-04       Impact factor: 5.157

7.  Interaction between single nucleotide polymorphisms in selenoprotein P and mitochondrial superoxide dismutase determines prostate cancer risk.

Authors:  Matthew L Cooper; Hans-Olov Adami; Henrik Grönberg; Fredrik Wiklund; Fiona R Green; Margaret P Rayman
Journal:  Cancer Res       Date:  2008-12-15       Impact factor: 12.701

8.  Selenium requirements are higher for glutathione peroxidase-1 mRNA than gpx1 activity in rat testis.

Authors:  Sonja C Schriever; Kimberly M Barnes; Jacqueline K Evenson; Anna M Raines; Roger A Sunde
Journal:  Exp Biol Med (Maywood)       Date:  2009-02-20

9.  Sepp1(UF) forms are N-terminal selenoprotein P truncations that have peroxidase activity when coupled with thioredoxin reductase-1.

Authors:  Suguru Kurokawa; Sofi Eriksson; Kristie L Rose; Sen Wu; Amy K Motley; Salisha Hill; Virginia P Winfrey; W Hayes McDonald; Mario R Capecchi; John F Atkins; Elias S J Arnér; Kristina E Hill; Raymond F Burk
Journal:  Free Radic Biol Med       Date:  2014-01-14       Impact factor: 7.376

10.  Association of selenoprotein p with Alzheimer's pathology in human cortex.

Authors:  Frederick P Bellinger; Qing-Ping He; Miyoko T Bellinger; Yanling Lin; Arjun V Raman; Lon R White; Marla J Berry
Journal:  J Alzheimers Dis       Date:  2008-11       Impact factor: 4.472
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