Kumar Sandrasegaran1, Enming Cui2,3, Reem Elkady2,4,5, Pauley Gasparis2, Gitasree Borthakur2, Mark Tann2, Suthat Liangpunsakul6,7. 1. Department of Radiology, Indiana University School of Medicine, UH 0279, 550 N. University Blvd, Indianapolis, IN, 46202, USA. ksandras@iupui.edu. 2. Department of Radiology, Indiana University School of Medicine, UH 0279, 550 N. University Blvd, Indianapolis, IN, 46202, USA. 3. Department of Radiology, Jiangmen Central Hospital, Jiangmen, China. 4. Department of Radiology, Assiut University, Assiut, Egypt. 5. Department of Radiology, Taibah University, Medina, Saudi Arabia. 6. Department of Medicine (Division of Hepatology), Indiana University School of Medicine, Indianapolis, IN, USA. 7. Department of Medicine, Robert Roudebush VA Medical Center, Indianapolis, IN, USA.
Abstract
OBJECTIVES: To determine the value of quantitative parameters of gadoxetate-enhanced magnetic resonance imaging (MRI) in predicting prognosis in patients with cirrhosis. METHODS: A cohort of 63 cirrhotic patients who had gadoxetate MRI and 2-year clinical follow-up was enrolled. Enhancement ratio (ER), contrast enhancement index (CEI) and contrast enhancement spleen index (CES) were calculated. The usefulness of these parameters and clinical scores, such as Child-Pugh score (CPS) and model for end stage liver disease (MELD), in predicting adverse outcomes, such as variceal bleeding (VB), hepatic encephalopathy (HE) and mortality at 2 years were evaluated. RESULTS: Fifteen, 31 and 27 patients, respectively, had VB, HE and mortality within 2 years. The ER at 15 min (ER 15) and CES at 20 min (CES 20) were found to be the best MRI predictors. Areas under the receiver operating characteristic curve (AUC) for predicting VB were 0.785, 0.729, 0.673, 0.714, respectively, for ER 15, CES 20, CPS and MELD scores. ER 15 of less than 48 had sensitivity of 96% and specificity of 84% for predicting onset of HE within 2 years. CONCLUSIONS: In patients with cirrhosis, ER 15 or CES 20 were equivalent or better predictors of major morbidity and mortality compared with commonly used clinical scores. KEY POINTS: • Gadoxetate parameters may identify cirrhotic patients at risk of adverse events. • Gadoxetate parameters usually show superior predictive values compared to clinical scores. • CES 20 score is associated with risk of mortality within 2 years.
OBJECTIVES: To determine the value of quantitative parameters of gadoxetate-enhanced magnetic resonance imaging (MRI) in predicting prognosis in patients with cirrhosis. METHODS: A cohort of 63 cirrhotic patients who had gadoxetate MRI and 2-year clinical follow-up was enrolled. Enhancement ratio (ER), contrast enhancement index (CEI) and contrast enhancement spleen index (CES) were calculated. The usefulness of these parameters and clinical scores, such as Child-Pugh score (CPS) and model for end stage liver disease (MELD), in predicting adverse outcomes, such as variceal bleeding (VB), hepatic encephalopathy (HE) and mortality at 2 years were evaluated. RESULTS: Fifteen, 31 and 27 patients, respectively, had VB, HE and mortality within 2 years. The ER at 15 min (ER 15) and CES at 20 min (CES 20) were found to be the best MRI predictors. Areas under the receiver operating characteristic curve (AUC) for predicting VB were 0.785, 0.729, 0.673, 0.714, respectively, for ER 15, CES 20, CPS and MELD scores. ER 15 of less than 48 had sensitivity of 96% and specificity of 84% for predicting onset of HE within 2 years. CONCLUSIONS: In patients with cirrhosis, ER 15 or CES 20 were equivalent or better predictors of major morbidity and mortality compared with commonly used clinical scores. KEY POINTS: • Gadoxetate parameters may identify cirrhotic patients at risk of adverse events. • Gadoxetate parameters usually show superior predictive values compared to clinical scores. • CES 20 score is associated with risk of mortality within 2 years.
Authors: Andreas Wibmer; Alexander M Prusa; Richard Nolz; Thomas Gruenberger; Martin Schindl; Ahmed Ba-Ssalamah Journal: Radiology Date: 2013-10-28 Impact factor: 11.105
Authors: Lucian Beer; Mattias Mandorfer; Nina Bastati; Sarah Poetter-Lang; Dietmar Tamandl; Dilyana Plamenova Stoyanova; Michael Christoph Elmer; Georg Semmler; Benedikt Simbrunner; Jacqueline C Hodge; Claude B Sirlin; Thomas Reiberger; Ahmed Ba-Ssalamah Journal: Eur Radiol Date: 2019-04-18 Impact factor: 5.315