| Literature DB >> 29651674 |
Ao Xie1, Jie Sheng1, Feng Zheng2.
Abstract
Kidney diseases are common and the incidence rate is increasing. Gut microbiota is involved in metabolic and immune regulation of the host. Genetic, alimentary and environmental disease factors may change gut flora and increase opportunistic and pathogenic bacteria, contributing to immune or non-immune mediated kidney diseases including IgA nephropathy and diabetic nephropathy. Additionally, bacterial metabolites may be a source of uremic toxins. Thus, identification of diversity, composition, and metabolic and immunologic features of gut bacteria in chronic kidney diseases may help understand pathogenetic mechanism and develop therapy for diseases.Entities:
Keywords: IgA nephropathy; chronic kidney disease; microbiota; uremia
Mesh:
Year: 2018 PMID: 29651674 DOI: 10.1007/s11655-017-2927-5
Source DB: PubMed Journal: Chin J Integr Med ISSN: 1672-0415 Impact factor: 1.978