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Literature DB >> 29651106

Senotherapeutics for healthy ageing.

Laura J Niedernhofer¹, Paul D Robbins¹.

Abstract

Mesh：

Year: 2018 PMID： 29651106 DOI： 10.1038/nrd.2018.44

Source DB: PubMed Journal: Nat Rev Drug Discov ISSN： 1474-1776 Impact factor: 84.694

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10 in total

1. NF-κB inhibition delays DNA damage-induced senescence and aging in mice.

Authors: Jeremy S Tilstra; Andria R Robinson; Jin Wang; Siobhán Q Gregg; Cheryl L Clauson; Daniel P Reay; Luigi A Nasto; Claudette M St Croix; Arvydas Usas; Nam Vo; Johnny Huard; Paula R Clemens; Donna B Stolz; Denis C Guttridge; Simon C Watkins; George A Garinis; Yinsheng Wang; Laura J Niedernhofer; Paul D Robbins
Journal: J Clin Invest Date: 2012-06-18 Impact factor: 14.808

2. JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age.

Authors: Ming Xu; Tamara Tchkonia; Husheng Ding; Mikolaj Ogrodnik; Ellen R Lubbers; Tamar Pirtskhalava; Thomas A White; Kurt O Johnson; Michael B Stout; Vojtech Mezera; Nino Giorgadze; Michael D Jensen; Nathan K LeBrasseur; James L Kirkland
Journal: Proc Natl Acad Sci U S A Date: 2015-11-02 Impact factor: 11.205

3. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders.

Authors: Darren J Baker; Tobias Wijshake; Tamar Tchkonia; Nathan K LeBrasseur; Bennett G Childs; Bart van de Sluis; James L Kirkland; Jan M van Deursen
Journal: Nature Date: 2011-11-02 Impact factor: 49.962

Review 4. Senescent cells: an emerging target for diseases of ageing.

Authors: Bennett G Childs; Martina Gluscevic; Darren J Baker; Remi-Martin Laberge; Dan Marquess; Jamie Dananberg; Jan M van Deursen
Journal: Nat Rev Drug Discov Date: 2017-07-21 Impact factor: 84.694

5. Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment.

Authors: Ok Hee Jeon; Chaekyu Kim; Remi-Martin Laberge; Marco Demaria; Sona Rathod; Alain P Vasserot; Jae Wook Chung; Do Hun Kim; Yan Poon; Nathaniel David; Darren J Baker; Jan M van Deursen; Judith Campisi; Jennifer H Elisseeff
Journal: Nat Med Date: 2017-04-24 Impact factor: 53.440

6. The Achilles' heel of senescent cells: from transcriptome to senolytic drugs.

Authors: Yi Zhu; Tamara Tchkonia; Tamar Pirtskhalava; Adam C Gower; Husheng Ding; Nino Giorgadze; Allyson K Palmer; Yuji Ikeno; Gene B Hubbard; Marc Lenburg; Steven P O'Hara; Nicholas F LaRusso; Jordan D Miller; Carolyn M Roos; Grace C Verzosa; Nathan K LeBrasseur; Jonathan D Wren; Joshua N Farr; Sundeep Khosla; Michael B Stout; Sara J McGowan; Heike Fuhrmann-Stroissnigg; Aditi U Gurkar; Jing Zhao; Debora Colangelo; Akaitz Dorronsoro; Yuan Yuan Ling; Amira S Barghouthy; Diana C Navarro; Tokio Sano; Paul D Robbins; Laura J Niedernhofer; James L Kirkland
Journal: Aging Cell Date: 2015-04-22 Impact factor: 9.304

7. Identification of HSP90 inhibitors as a novel class of senolytics.

Authors: Heike Fuhrmann-Stroissnigg; Yuan Yuan Ling; Jing Zhao; Sara J McGowan; Yi Zhu; Robert W Brooks; Diego Grassi; Siobhan Q Gregg; Jennifer L Stripay; Akaitz Dorronsoro; Lana Corbo; Priscilla Tang; Christina Bukata; Nadja Ring; Mauro Giacca; Xuesen Li; Tamara Tchkonia; James L Kirkland; Laura J Niedernhofer; Paul D Robbins
Journal: Nat Commun Date: 2017-09-04 Impact factor: 14.919

8. New agents that target senescent cells: the flavone, fisetin, and the BCL-X_L inhibitors, A1331852 and A1155463.

Authors: Yi Zhu; Ewald J Doornebal; Tamar Pirtskhalava; Nino Giorgadze; Mark Wentworth; Heike Fuhrmann-Stroissnigg; Laura J Niedernhofer; Paul D Robbins; Tamara Tchkonia; James L Kirkland
Journal: Aging (Albany NY) Date: 2017-03-08 Impact factor: 5.682

9. Cellular senescence mediates fibrotic pulmonary disease.

Authors: Marissa J Schafer; Thomas A White; Koji Iijima; Andrew J Haak; Giovanni Ligresti; Elizabeth J Atkinson; Ann L Oberg; Jodie Birch; Hanna Salmonowicz; Yi Zhu; Daniel L Mazula; Robert W Brooks; Heike Fuhrmann-Stroissnigg; Tamar Pirtskhalava; Y S Prakash; Tamara Tchkonia; Paul D Robbins; Marie Christine Aubry; João F Passos; James L Kirkland; Daniel J Tschumperlin; Hirohito Kita; Nathan K LeBrasseur
Journal: Nat Commun Date: 2017-02-23 Impact factor: 14.919

10. p16(Ink4a) and senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli.

Authors: Brandon M Hall; Vitaly Balan; Anatoli S Gleiberman; Evguenia Strom; Peter Krasnov; Lauren P Virtuoso; Elena Rydkina; Slavoljub Vujcic; Karina Balan; Ilya I Gitlin; Katerina I Leonova; Camila R Consiglio; Sandra O Gollnick; Olga B Chernova; Andrei V Gudkov
Journal: Aging (Albany NY) Date: 2017-08-02 Impact factor: 5.682

10 in total

37 in total

1. Inhibition of 3-phosphoinositide-dependent protein kinase 1 (PDK1) can revert cellular senescence in human dermal fibroblasts.

Authors: Sugyun An; Si-Young Cho; Junsoo Kang; Soobeom Lee; Hyung-Su Kim; Dae-Jin Min; EuiDong Son; Kwang-Hyun Cho
Journal: Proc Natl Acad Sci U S A Date: 2020-11-23 Impact factor: 11.205

Review 10. Vascular Endothelial Senescence: Pathobiological Insights, Emerging Long Noncoding RNA Targets, Challenges and Therapeutic Opportunities.

Authors: Xinghui Sun; Mark W Feinberg
Journal: Front Physiol Date: 2021-06-16 Impact factor: 4.566

Senotherapeutics for healthy ageing.

1. NF-κB inhibition delays DNA damage-induced senescence and aging in mice.

2. JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age.

3. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders.

Review 4. Senescent cells: an emerging target for diseases of ageing.

5. Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment.

6. The Achilles' heel of senescent cells: from transcriptome to senolytic drugs.

7. Identification of HSP90 inhibitors as a novel class of senolytics.

8. New agents that target senescent cells: the flavone, fisetin, and the BCL-X_L inhibitors, A1331852 and A1155463.

9. Cellular senescence mediates fibrotic pulmonary disease.

10. p16(Ink4a) and senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli.

1. Inhibition of 3-phosphoinositide-dependent protein kinase 1 (PDK1) can revert cellular senescence in human dermal fibroblasts.

2. Senotherapeutic drugs for human intervertebral disc degeneration and low back pain.

Review 3. Cellular senescence and radiation-induced pulmonary fibrosis.

4. Development of Clinical Trials to Extend Healthy Lifespan.

Review 5. Cytoplasmic DNA: sources, sensing, and role in aging and disease.

Review 6. Recent advances in the discovery of senolytics.

7. Exploring the fuzzy border between senolytics and senomorphics with chemoinformatics and systems pharmacology.

Review 8. Mitochondria-targeted senotherapeutic interventions.

Review 9. The Role of Senescent Cells in Acquired Drug Resistance and Secondary Cancer in BRAFi-Treated Melanoma.

Review 10. Vascular Endothelial Senescence: Pathobiological Insights, Emerging Long Noncoding RNA Targets, Challenges and Therapeutic Opportunities.