Literature DB >> 29644769

Reactive Chemical Probes: Beyond the Kinase Cysteinome.

Lyn H Jones1.   

Abstract

The reaction of small-molecule chemical probes with proteins has been harnessed to develop covalent inhibitor drugs and protein-profiling technologies. This Essay discusses some of the recent enhancements to the chemical biology toolkit that are enabling the study of previously unchartered areas of chemoproteomic space. An analysis of the kinome is used to illustrate the potential for these approaches enable the pursuit of new targets using reactive chemical probes.
© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  chemical probes; chemoproteomics; kinases; lysine; tyrosine

Mesh：

Substances：

Year:  2018        PMID： 29644769     DOI： 10.1002/anie.201802693

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  6 in total

Review 1.  Recent Advances in Selective and Irreversible Covalent Ligand Development and Validation.

Authors:  Tinghu Zhang; John M Hatcher; Mingxing Teng; Nathanael S Gray; Milka Kostic
Journal:  Cell Chem Biol       Date:  2019-10-17       Impact factor: 8.116

Review 2.  Structure-based design and analysis of SuFEx chemical probes.

Authors:  Lyn H Jones; Jeffery W Kelly
Journal:  RSC Med Chem       Date:  2020-01-06

3.  Rh-Catalyzed Highly Enantioselective Synthesis of Aliphatic Sulfonyl Fluorides.

Authors:  Balakrishna Moku; Wan-Yin Fang; Jing Leng; Linxian Li; Gao-Feng Zha; K P Rakesh; Hua-Li Qin
Journal:  iScience       Date:  2019-10-30

4.  A targeted covalent inhibitor of p97 with proteome-wide selectivity.

Authors:  Zi Ye; Ke Wang; Lianguo Chen; Xiaofeng Jin; Hao Chen; Guanghui Tang; Shao Q Yao; Zhiqiang Feng; Chong-Jing Zhang
Journal:  Acta Pharm Sin B       Date:  2021-09-08       Impact factor: 11.413

5.  Cereblon covalent modulation through structure-based design of histidine targeting chemical probes.

Authors:  Justin T Cruite; Geoffrey P Dann; Jianwei Che; Katherine A Donovan; Silas Ferrao; Scott B Ficarro; Eric S Fischer; Nathanael S Gray; Fidel Huerta; Nikki R Kong; Hu Liu; Jarrod A Marto; Rebecca J Metivier; Radosław P Nowak; Breanna L Zerfas; Lyn H Jones
Journal:  RSC Chem Biol       Date:  2022-07-08

Review 6.  The Application of Fluorine-Containing Reagents in Structural Proteomics.

Authors:  Ming Cheng; Chunyang Guo; Michael L Gross
Journal:  Angew Chem Int Ed Engl       Date:  2020-01-16       Impact factor: 15.336
  6 in total

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