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Literature DB >> 33479601

Structure-based design and analysis of SuFEx chemical probes.

Abstract

The discerning reactivity of sulfur(vi)-fluoride exchange (SuFEx) chemistry has enabled the context-specific labeling of protein binding sites by chemical probes that incorporate these versatile warheads. Emerging information from protein-probe structures and proteomic mapping experiments is helping advance our understanding of the protein microenvironment that dictates the reactivity of targetable amino acid residues. This review explores these new findings that should influence the future rational design of SuFEx probes for a multitude of applications in chemical biology and drug discovery. This journal is © The Royal Society of Chemistry 2020.

Entities: Chemical

Year: 2020 PMID： 33479601 PMCID： PMC7460715 DOI： 10.1039/c9md00542k

Source DB: PubMed Journal: RSC Med Chem ISSN： 2632-8682

53 in total

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Journal: ACS Chem Biol Date: 2017-07-20 Impact factor: 5.100

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7. A study of the reactivity of S^(VI)-F containing warheads with nucleophilic amino-acid side chains under physiological conditions.

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Journal: Org Biomol Chem Date: 2017-11-22 Impact factor: 3.876

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Authors: Maarten L J Doornbos; Xuesong Wang; Sophie C Vermond; Luc Peeters; Laura Pérez-Benito; Andrés A Trabanco; Hilde Lavreysen; José María Cid; Laura H Heitman; Gary Tresadern; Adriaan P IJzerman
Journal: J Med Chem Date: 2018-03-07 Impact factor: 7.446

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Journal: Sci Rep Date: 2016-08-16 Impact factor: 4.379

10. Structural Basis for Binding of Allosteric Drug Leads in the Adenosine A₁ Receptor.

Authors: Yinglong Miao; Apurba Bhattarai; Anh T N Nguyen; Arthur Christopoulos; Lauren T May
Journal: Sci Rep Date: 2018-11-15 Impact factor: 4.379

11 in total

Review 1. Reactive chemistry for covalent probe and therapeutic development.

Authors: R Justin Grams; Ku-Lung Hsu
Journal: Trends Pharmacol Sci Date: 2022-01-06 Impact factor: 14.819

2. Calcium Bistriflimide-Mediated Sulfur(VI)-Fluoride Exchange (SuFEx): Mechanistic Insights toward Instigating Catalysis.

Authors: Brian Han; Samuel R Khasnavis; Matthew Nwerem; Michael Bertagna; Nicholas D Ball; O Maduka Ogba
Journal: Inorg Chem Date: 2022-06-14 Impact factor: 5.436

3. Covalent labeling of a chromatin reader domain using proximity-reactive cyclic peptides.

Authors: Meng Yao Zhang; Hyunjun Yang; Gloria Ortiz; Michael J Trnka; Nektaria Petronikolou; Alma L Burlingame; William F DeGrado; Danica Galonić Fujimori
Journal: Chem Sci Date: 2022-05-12 Impact factor: 9.969

4. Amino-oxetanes as amide isosteres by an alternative defluorosulfonylative coupling of sulfonyl fluorides.

Authors: Juan J Rojas; Rosemary A Croft; Alistair J Sterling; Edward L Briggs; Daniele Antermite; Daniel C Schmitt; Luka Blagojevic; Peter Haycock; Andrew J P White; Fernanda Duarte; Chulho Choi; James J Mousseau; James A Bull
Journal: Nat Chem Date: 2022-01-27 Impact factor: 24.274

5. Photoredox catalytic radical fluorosulfonylation of olefins enabled by a bench-stable redox-active fluorosulfonyl radical precursor.

Authors: Peng Wang; Honghai Zhang; Xingliang Nie; Tianxiao Xu; Saihu Liao
Journal: Nat Commun Date: 2022-06-11 Impact factor: 17.694