| Literature DB >> 29638123 |
Pablo Tovillas1, Iván García1, Paula Oroz1, Nuria Mazo1, Alberto Avenoza1, Francisco Corzana1, Gonzalo Jiménez-Osés1, Jesús H Busto1, Jesús M Peregrina1.
Abstract
Starting from commercially available ( S)-isoserine and effectively accessible ( S)-α-methylserine, enantiopure cyclic sulfamidates have been prepared as chiral building blocks for the synthesis of various S- and O-glycosylated amino acid derivatives, including unnatural variants of the Tn antigen, through highly chemo-, regio-, and stereoselective nucleophilic ring-opening reactions with carbohydrate C1- S- and C1- O-nucleophiles.Entities:
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Year: 2018 PMID： 29638123 DOI： 10.1021/acs.joc.7b03225
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354