Andrea L Rosso1, Andrea L Metti1, Nancy W Glynn1, Robert M Boudreau1, W Jack Rejeski2, Nicolaas Bohnen3,4, Haiying Chen5, Neil M Johannsen6, Abby C King7, Todd M Manini8, Marco Pahor8, Stephanie A Studenski9, Carlos A Vaz Fragoso10, Caterina Rosano1. 1. Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania. 2. Department of Health and Exercise Science, Wake Forest University, Winston-Salem, North Carolina. 3. Department of Neurology, University of Michigan, Ann Arbor, Michigan. 4. Department of Radiology, University of Michigan, Ann Arbor, Michigan. 5. Department of Biostatistical Sciences, School of Medicine, Wake Forest University, Winston-Salem, North Carolina. 6. School of Kinesiology, Louisiana State University, Baton Rouge, Louisiana. 7. Department of Health Research and Policy, Stanford University, Palo Alto, California. 8. Department of Aging and Geriatric Research, University of Florida, Gainesville, Florida. 9. Longitudinal Studies Section, National Institute on Aging, Baltimore, Maryland. 10. Department of Geriatrics, School of Medicine, Yale University, New Haven, Connecticut.
Abstract
OBJECTIVES: To determine whether intervention-induced physical activity (PA) changes in sedentary older adults differed according to dopamine-related genotype. DESIGN: Randomized clinical trial (Lifestyle Interventions and Independence for Elders Trial (2010-13)). SETTING: Multicenter study, 8 U.S. PARTICIPANTS: Volunteer sample of sedentary adults aged 70 to 89 at risk of disability (N=1635). INTERVENTIONS:Structured PA versus health education (HE) for an average of 2.6 years. MEASUREMENTS: Single-nucleotide polymorphisms of dopamine-related genes (dopamine receptor (DR) D1, DRD2, DRD3, and catechol-O-methyltransferase (COMT)) were assessed. Average moderate to vigorous PA (MVPA) was calculated using accelerometry (min/d) at baseline and 6, 12, and 24 months. Between-arm MVPA differences according to genotype and genotype with square root-transformed MVPA separately according to arm were tested, stratified according to race, and adjusted for multiple comparisons. RESULTS:White participants in the PA arm (n=513) had higher average square root transformed MVPA (4.91±1.91)than those in the HE arm (n=538) (4.51±1.82) (p=.001). Between-arm differences were greater for DRD2 Met/Met (high dopamine; HE: 4.76±1.80, PA: 5.53±1.60, p=.03) than Val/Val (low dopamine; HE: 4.58±1.92, PA: 4.81±1.83, p=.16); results were similar for COMT. In the PA arm, DRD2 Met/Met was associated with higher average MVPA (5.39±2.00) than Met/Val (4.46±2.51) (p=.01) and Val/Val (4.65±2.71) (p=.01). There were no associations for other genes. Associations were not significant in blacks but followed similar trends. CONCLUSION: Higher dopamine signaling may support changes in PA during an intervention. The role of dopamine-related pathways in promoting PA participation and enhancing response to interventions in sedentary older adults should be studied. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT01072500.
RCT Entities:
OBJECTIVES: To determine whether intervention-induced physical activity (PA) changes in sedentary older adults differed according to dopamine-related genotype. DESIGN: Randomized clinical trial (Lifestyle Interventions and Independence for Elders Trial (2010-13)). SETTING: Multicenter study, 8 U.S. PARTICIPANTS: Volunteer sample of sedentary adults aged 70 to 89 at risk of disability (N=1635). INTERVENTIONS: Structured PA versus health education (HE) for an average of 2.6 years. MEASUREMENTS: Single-nucleotide polymorphisms of dopamine-related genes (dopamine receptor (DR) D1, DRD2, DRD3, and catechol-O-methyltransferase (COMT)) were assessed. Average moderate to vigorous PA (MVPA) was calculated using accelerometry (min/d) at baseline and 6, 12, and 24 months. Between-arm MVPA differences according to genotype and genotype with square root-transformed MVPA separately according to arm were tested, stratified according to race, and adjusted for multiple comparisons. RESULTS: White participants in the PA arm (n=513) had higher average square root transformed MVPA (4.91±1.91)than those in the HE arm (n=538) (4.51±1.82) (p=.001). Between-arm differences were greater for DRD2Met/Met (high dopamine; HE: 4.76±1.80, PA: 5.53±1.60, p=.03) than Val/Val (low dopamine; HE: 4.58±1.92, PA: 4.81±1.83, p=.16); results were similar for COMT. In the PA arm, DRD2Met/Met was associated with higher average MVPA (5.39±2.00) than Met/Val (4.46±2.51) (p=.01) and Val/Val (4.65±2.71) (p=.01). There were no associations for other genes. Associations were not significant in blacks but followed similar trends. CONCLUSION: Higher dopamine signaling may support changes in PA during an intervention. The role of dopamine-related pathways in promoting PA participation and enhancing response to interventions in sedentary older adults should be studied. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT01072500.
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