C Pulcini1, F Binda2, A S Lamkang3, A Trett3, E Charani4, D A Goff5, S Harbarth6, S L Hinrichsen7, G Levy-Hara8, M Mendelson9, D Nathwani10, R Gunturu11, S Singh12, A Srinivasan13, V Thamlikitkul14, K Thursky15, E Vlieghe16, H Wertheim17, M Zeng18, S Gandra3, R Laxminarayan19. 1. Université de Lorraine, APEMAC, Nancy, France; Université de Lorraine, CHRU-Nancy, Infectious Diseases Department, Nancy, France. Electronic address: celine.pulcini@univ-lorraine.fr. 2. Université de Lorraine, APEMAC, Nancy, France; Université de Lorraine, CHRU-Nancy, Infectious Diseases Department, Nancy, France; University of Milan, Department of Biomedical and Clinical Sciences «Luigi Sacco», Milan, Italy. 3. Center for Disease Dynamics, Economics & Policy (CDDEP), New Delhi, India. 4. Imperial College London, Department of Medicine, NIHR Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, London, UK. 5. The Ohio State University Wexner Medical Center, Columbus, OH, USA. 6. Geneva University Hospitals, Infection Control Program and WHO Collaborating Center, Faculty of Medicine, Geneva, Switzerland. 7. Universidade Federal de Pernambuco (UFPE), Tropical Diseases Department, Recife, Brazil. 8. Hospital Carlos G Durand, Unit of Infectious Diseases, Buenos Aires, Argentina. 9. Groote Schuur Hospital, University of Cape Town, Department of Medicine, Division of Infectious Diseases & HIV Medicine, Cape Town, South Africa. 10. Ninewells Hospital and Medical School, Dundee, UK. 11. The Aga Khan University Hospital, Dept. of Pathology, Division of Clinical Microbiology, Nairobi, Kenya. 12. Amrita Institute of Medical Sciences, Kochi, Kerala, India. 13. Centers for Disease Control and Prevention, Atlanta, GA, USA. 14. Mahidol University, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand. 15. National Centre for Antimicrobial Stewardship, Royal Melbourne Hospital at the Peter Doherty Institute, Melbourne, Australia. 16. University Hospital Antwerp, Department of General Internal Medicine, Infectious Diseases & Tropical Medicine, Antwerp, Belgium; University of Antwerp, Global Health Institute, Antwerp, Belgium; Institute of Tropical Medicine, Department of Clinical Sciences, Antwerp, Belgium. 17. Radboudumc, Department of Medical Microbiology and Radboud Center for Infectious Diseases, Nijmegen, The Netherlands. 18. Children's Hospital of Fudan University, Department of Infectious Diseases, Shanghai, China. 19. Center for Disease Dynamics, Economics & Policy (CDDEP), New Delhi, India; Princeton University, Princeton, NJ, USA.
Abstract
OBJECTIVES: With increasing global interest in hospital antimicrobial stewardship (AMS) programmes, there is a strong demand for core elements of AMS to be clearly defined on the basis of principles of effectiveness and affordability. To date, efforts to identify such core elements have been limited to Europe, Australia, and North America. The aim of this study was to develop a set of core elements and their related checklist items for AMS programmes that should be present in all hospitals worldwide, regardless of resource availability. METHODS: A literature review was performed by searching Medline and relevant websites to retrieve a list of core elements and items that could have global relevance. These core elements and items were evaluated by an international group of AMS experts using a structured modified Delphi consensus procedure, using two-phased online in-depth questionnaires. RESULTS: The literature review identified seven core elements and their related 29 checklist items from 48 references. Fifteen experts from 13 countries in six continents participated in the consensus procedure. Ultimately, all seven core elements were retained, as well as 28 of the initial checklist items plus one that was newly suggested, all with ≥80% agreement; 20 elements and items were rephrased. CONCLUSIONS: This consensus on core elements for hospital AMS programmes is relevant to both high- and low-to-middle-income countries and could facilitate the development of national AMS stewardship guidelines and adoption by healthcare settings worldwide.
OBJECTIVES: With increasing global interest in hospital antimicrobial stewardship (AMS) programmes, there is a strong demand for core elements of AMS to be clearly defined on the basis of principles of effectiveness and affordability. To date, efforts to identify such core elements have been limited to Europe, Australia, and North America. The aim of this study was to develop a set of core elements and their related checklist items for AMS programmes that should be present in all hospitals worldwide, regardless of resource availability. METHODS: A literature review was performed by searching Medline and relevant websites to retrieve a list of core elements and items that could have global relevance. These core elements and items were evaluated by an international group of AMS experts using a structured modified Delphi consensus procedure, using two-phased online in-depth questionnaires. RESULTS: The literature review identified seven core elements and their related 29 checklist items from 48 references. Fifteen experts from 13 countries in six continents participated in the consensus procedure. Ultimately, all seven core elements were retained, as well as 28 of the initial checklist items plus one that was newly suggested, all with ≥80% agreement; 20 elements and items were rephrased. CONCLUSIONS: This consensus on core elements for hospital AMS programmes is relevant to both high- and low-to-middle-income countries and could facilitate the development of national AMS stewardship guidelines and adoption by healthcare settings worldwide.
Authors: Jean-François Timsit; Matteo Bassetti; Olaf Cremer; George Daikos; Jan de Waele; Andre Kallil; Eric Kipnis; Marin Kollef; Kevin Laupland; Jose-Artur Paiva; Jesús Rodríguez-Baño; Étienne Ruppé; Jorge Salluh; Fabio Silvio Taccone; Emmanuel Weiss; François Barbier Journal: Intensive Care Med Date: 2019-01-18 Impact factor: 17.440
Authors: Abraham S Alabi; Stephen W Picka; Reubvera Sirleaf; Pacifique R Ntirenganya; Arnold Ayebare; Nidia Correa; Sarah Anyango; Gerald Ekwen; Emmanuel Agu; Rebecca Cook; John Yarngrorble; Ibrahim Sanoe; Henry Dugulu; Emmanuel Wiefue; Diana Gahn-Smith; Francis N Kateh; Ezekiel F Hallie; Christiane G Sidonie; Aaron O Aboderin; David Vassellee; Damien Bishop; Daniel Lohmann; Manja Naumann-Hustedt; Alois Dörlemann; Frieder Schaumburg Journal: JAC Antimicrob Resist Date: 2022-06-24
Authors: Melissa D Johnson; Russell E Lewis; Elizabeth S Dodds Ashley; Luis Ostrosky-Zeichner; Theoklis Zaoutis; George R Thompson; David R Andes; Thomas J Walsh; Peter G Pappas; Oliver A Cornely; John R Perfect; Dimitrios P Kontoyiannis Journal: J Infect Dis Date: 2020-08-05 Impact factor: 5.226
Authors: P F Dutey-Magni; M J Gill; D McNulty; G Sohal; A Hayward; L Shallcross; Niall Anderson; Elise Crayton; Gillian Forbes; Arnoupe Jhass; Emma Richardson; Michelle Richardson; Patrick Rockenschaub; Catherine Smith; Elizabeth Sutton; Rosanna Traina; Lou Atkins; Anne Conolly; Spiros Denaxas; Ellen Fragaszy; Rob Horne; Patty Kostkova; Fabiana Lorencatto; Susan Michie; Jennifer Mindell; John Robson; Claire Royston; Carolyn Tarrant; James Thomas; Jonathan West; Haydn Williams; Nadia Elsay; Chris Fuller Journal: JAC Antimicrob Resist Date: 2021-03-04