| Literature DB >> 29618663 |
Kang Li1, Rodosthenis S Rodosthenous2, Fatah Kashanchi3, Thomas Gingeras4, Stephen J Gould5, Lillian S Kuo6, Peter Kurre7, Hakho Lee8, Joshua N Leonard9, Huiping Liu10, Tania B Lombo11, Stefan Momma12, John P Nolan13, Margaret J Ochocinska14, D Michiel Pegtel15, Yoel Sadovsky16, Francisco Sánchez-Madrid17, Kayla M Valdes18, Kasey C Vickers19, Alissa M Weaver20, Kenneth W Witwer21, Yong Zeng22, Saumya Das2, Robert L Raffai1, T Kevin Howcroft23.
Abstract
Extracellular RNA (exRNA) has emerged as an important transducer of intercellular communication. Advancing exRNA research promises to revolutionize biology and transform clinical practice. Recent efforts have led to cutting-edge research and expanded knowledge of this new paradigm in cell-to-cell crosstalk; however, gaps in our understanding of EV heterogeneity and exRNA diversity pose significant challenges for continued development of exRNA diagnostics and therapeutics. To unravel this complexity, the NIH convened expert teams to discuss the current state of the science, define the significant bottlenecks, and brainstorm potential solutions across the entire exRNA research field. The NIH Strategic Workshop on Extracellular RNA Transport helped identify mechanistic and clinical research opportunities for exRNA biology and provided recommendations on high priority areas of research that will advance the exRNA field.Mesh：
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Year: 2018 PMID： 29618663 PMCID： PMC5928855 DOI： 10.1172/jci.insight.98942
Source DB: PubMed Journal: JCI Insight ISSN： 2379-3708