| Literature DB >> 30951667 |
Saumya Das1, K Mark Ansel2, Markus Bitzer3, Xandra O Breakefield4, Alain Charest5, David J Galas6, Mark B Gerstein7, Mihir Gupta8, Aleksandar Milosavljevic9, Michael T McManus10, Tushar Patel11, Robert L Raffai12, Joel Rozowsky13, Matthew E Roth9, Julie A Saugstad14, Kendall Van Keuren-Jensen15, Alissa M Weaver16, Louise C Laurent17.
Abstract
The Extracellular RNA Communication Consortium (ERCC) was launched to accelerate progress in the new field of extracellular RNA (exRNA) biology and to establish whether exRNAs and their carriers, including extracellular vesicles (EVs), can mediate intercellular communication and be utilized for clinical applications. Phase 1 of the ERCC focused on exRNA/EV biogenesis and function, discovery of exRNA biomarkers, development of exRNA/EV-based therapeutics, and construction of a robust set of reference exRNA profiles for a variety of biofluids. Here, we present progress by ERCC investigators in these areas, and we discuss collaborative projects directed at development of robust methods for EV/exRNA isolation and analysis and tools for sharing and computational analysis of exRNA profiling data.Entities:
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Year: 2019 PMID： 30951667 PMCID： PMC6601620 DOI： 10.1016/j.cell.2019.03.023
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 66.850