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Literature DB >> 29610213

Coping with an Essential Poison: a Genetic Suppressor Analysis Corroborates a Key Function of c-di-AMP in Controlling Potassium Ion Homeostasis in Gram-Positive Bacteria.

Abstract

Cyclic di-AMP (c-di-AMP) is an important second messenger in bacteria. In most Firmicutes, the molecule is required for growth in complex media but also toxic upon accumulation. In an article on their current study, Zarrella and coworkers present a suppressor analysis of a Streptococcus pneumoniae strain that is unable to degrade c-di-AMP (T. M. Zarrella, D. W. Metzger, and G. Bai, J Bacteriol 200:e00045-18, 2018, https://doi.org/10.1128/JB.00045-18). Their study identifies new links between c-di-AMP and potassium homeostasis and supports the hypothesis that c-di-AMP serves as a second messenger to report about the intracellular potassium concentrations.

Entities: Chemical Species

Keywords: Streptococcus pneumoniae; diadenylate cyclase; phosphodiesterase; potassium uptake; second messenger

Mesh：

Substances：

Year: 2018 PMID： 29610213 PMCID： PMC5971470 DOI： 10.1128/JB.00166-18

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

40 in total

1. Control of potassium homeostasis is an essential function of the second messenger cyclic di-AMP in Bacillus subtilis.

Authors: Jan Gundlach; Christina Herzberg; Volkhard Kaever; Katrin Gunka; Tamara Hoffmann; Martin Weiß; Johannes Gibhardt; Andrea Thürmer; Dietrich Hertel; Rolf Daniel; Erhard Bremer; Fabian M Commichau; Jörg Stülke
Journal: Sci Signal Date: 2017-04-18 Impact factor: 8.192

2. Two DHH subfamily 1 proteins contribute to pneumococcal virulence and confer protection against pneumococcal disease.

Authors: L E Cron; K Stol; P Burghout; S van Selm; E R Simonetti; H J Bootsma; P W M Hermans
Journal: Infect Immun Date: 2011-07-18 Impact factor: 3.441

3. DisA and c-di-AMP act at the intersection between DNA-damage response and stress homeostasis in exponentially growing Bacillus subtilis cells.

Authors: Carolina Gándara; Juan C Alonso
Journal: DNA Repair (Amst) Date: 2015-01-06

Review 4. Too much of a good thing: regulated depletion of c-di-AMP in the bacterial cytoplasm.

Authors: TuAnh Ngoc Huynh; Joshua J Woodward
Journal: Curr Opin Microbiol Date: 2016-01-07 Impact factor: 7.934

5. Stress Suppressor Screening Leads to Detection of Regulation of Cyclic di-AMP Homeostasis by a Trk Family Effector Protein in Streptococcus pneumoniae.

Authors: Tiffany M Zarrella; Dennis W Metzger; Guangchun Bai
Journal: J Bacteriol Date: 2018-05-24 Impact factor: 3.490

6. Cyclic di-AMP homeostasis in bacillus subtilis: both lack and high level accumulation of the nucleotide are detrimental for cell growth.

Authors: Felix M P Mehne; Katrin Gunka; Hinnerk Eilers; Christina Herzberg; Volkhard Kaever; Jörg Stülke
Journal: J Biol Chem Date: 2012-11-28 Impact factor: 5.157

7. Lysozyme resistance in Streptococcus suis is highly variable and multifactorial.

Authors: Paul J Wichgers Schreur; Christian van Weeghel; Johanna M J Rebel; Mari A Smits; Jos P M van Putten; Hilde E Smith
Journal: PLoS One Date: 2012-04-30 Impact factor: 3.240

8. Identification of the Components Involved in Cyclic Di-AMP Signaling in Mycoplasma pneumoniae.

Authors: Cedric Blötz; Katrin Treffon; Volkhard Kaever; Frank Schwede; Elke Hammer; Jörg Stülke
Journal: Front Microbiol Date: 2017-07-13 Impact factor: 5.640

9. Comprehensive identification of essential Staphylococcus aureus genes using Transposon-Mediated Differential Hybridisation (TMDH).

Authors: Roy R Chaudhuri; Andrew G Allen; Paul J Owen; Gil Shalom; Karl Stone; Marcus Harrison; Timothy A Burgis; Michael Lockyer; Jorge Garcia-Lara; Simon J Foster; Stephen J Pleasance; Sarah E Peters; Duncan J Maskell; Ian G Charles
Journal: BMC Genomics Date: 2009-07-01 Impact factor: 3.969

Review 10. Cyclic di-AMP: another second messenger enters the fray.

Authors: Rebecca M Corrigan; Angelika Gründling
Journal: Nat Rev Microbiol Date: 2013-07-01 Impact factor: 60.633

15 in total

Review 1. A decade of research on the second messenger c-di-AMP.

Authors: Wen Yin; Xia Cai; Hongdan Ma; Li Zhu; Yuling Zhang; Shan-Ho Chou; Michael Y Galperin; Jin He
Journal: FEMS Microbiol Rev Date: 2020-11-24 Impact factor: 16.408

2. c-di-AMP-Regulated K⁺ Importer KtrAB Affects Biofilm Formation, Stress Response, and SpeB Expression in Streptococcus pyogenes.

Authors: Sabrina Faozia; Tazin Fahmi; Gary C Port; Kyu Hong Cho
Journal: Infect Immun Date: 2021-03-17 Impact factor: 3.441

Coping with an Essential Poison: a Genetic Suppressor Analysis Corroborates a Key Function of c-di-AMP in Controlling Potassium Ion Homeostasis in Gram-Positive Bacteria.

1. Control of potassium homeostasis is an essential function of the second messenger cyclic di-AMP in Bacillus subtilis.

2. Two DHH subfamily 1 proteins contribute to pneumococcal virulence and confer protection against pneumococcal disease.

3. DisA and c-di-AMP act at the intersection between DNA-damage response and stress homeostasis in exponentially growing Bacillus subtilis cells.

Review 4. Too much of a good thing: regulated depletion of c-di-AMP in the bacterial cytoplasm.

5. Stress Suppressor Screening Leads to Detection of Regulation of Cyclic di-AMP Homeostasis by a Trk Family Effector Protein in Streptococcus pneumoniae.

6. Cyclic di-AMP homeostasis in bacillus subtilis: both lack and high level accumulation of the nucleotide are detrimental for cell growth.

7. Lysozyme resistance in Streptococcus suis is highly variable and multifactorial.

8. Identification of the Components Involved in Cyclic Di-AMP Signaling in Mycoplasma pneumoniae.

9. Comprehensive identification of essential Staphylococcus aureus genes using Transposon-Mediated Differential Hybridisation (TMDH).

Review 10. Cyclic di-AMP: another second messenger enters the fray.

Review 1. A decade of research on the second messenger c-di-AMP.

2. c-di-AMP-Regulated K⁺ Importer KtrAB Affects Biofilm Formation, Stress Response, and SpeB Expression in Streptococcus pyogenes.

3. Onward and [K⁺]Upward: a New Potassium Importer under the Spell of Cyclic di-AMP.

4. Porphyromonas gingivalis Tyrosine Kinase Is a Fitness Determinant in Polymicrobial Infections.

5. Cyclic di-AMP, a second messenger of primary importance: tertiary structures and binding mechanisms.

Review 6. The Many Roles of the Bacterial Second Messenger Cyclic di-AMP in Adapting to Stress Cues.

7. c-di-AMP Accumulation Impairs Muropeptide Synthesis in Listeria monocytogenes.

Review 8. Beyond Homeostasis: Potassium and Pathogenesis during Bacterial Infections.

9. c-di-AMP Is Essential for the Virulence of Enterococcus faecalis.

10. Structural basis of KdpD histidine kinase binding to the second messenger c-di-AMP.