Florence Buseyne1,2, Edouard Betsem1,2,3, Thomas Montange1,2, Richard Njouom4, Chanceline Bilounga Ndongo5, Olivier Hermine6,7,8, Antoine Gessain1,2. 1. Unité d'épidémiologie et Physiopathologie des Virus Oncogènes, Institut Pasteur, Paris, France. 2. UMR CNRS 3569, Paris, France. 3. Université of Yaoundé I, Yaoundé, Cameroon. 4. Centre Pasteur du Cameroun, Yaoundé, Cameroon. 5. Ministère de la Santé Publique, Yaoundé, Cameroon. 6. INSERM UMR 1163, CNRS ERL 8254, Paris, France. 7. Hôpital Necker, Université Paris Descartes, Sorbonne Paris Cité, Paris, France. 8. Laboratoire d'Excellence GR-Ex, Paris, France.
Abstract
Background: A spillover of simian foamy virus (SFV) to humans, following bites from infected nonhuman primates (NHPs), is ongoing in exposed populations. These retroviruses establish persistent infections of unknown physiological consequences to the human host. Methods: We performed a case-control study to compare 24 Cameroonian hunters infected with gorilla SFV and 24 controls matched for age and ethnicity. A complete physical examination and blood test were performed for all participants. Logistic regression and Wilcoxon signed rank tests were used to compare cases and controls. Results: The cases had significantly lower levels of hemoglobin than the controls (median, 12.7 vs 14.4 g/dL; P = .01). Basophil levels were also significantly lower in cases than controls, with no differences for other leukocyte subsets. Cases had significantly higher urea, creatinine, protein, creatinine phosphokinase, and lactate dehydrogenase levels and lower bilirubin levels than controls. Cases and controls had similar frequencies of general, cutaneous, gastrointestinal, neurological, and cardiorespiratory signs. Conclusions: The first case-control study of apparently healthy SFV-infected Cameroonian hunters showed the presence of hematological abnormalities. A thorough clinical and laboratory workup is now needed to establish the medical relevance of these observations because more than half of cases had mild or moderate anemia. Clinical Trials Registration: NCT03225794.
Background: A spillover of simian foamy virus (SFV) to humans, following bites from infected nonhuman primates (NHPs), is ongoing in exposed populations. These retroviruses establish persistent infections of unknown physiological consequences to the human host. Methods: We performed a case-control study to compare 24 Cameroonian hunters infected with gorilla SFV and 24 controls matched for age and ethnicity. A complete physical examination and blood test were performed for all participants. Logistic regression and Wilcoxon signed rank tests were used to compare cases and controls. Results: The cases had significantly lower levels of hemoglobin than the controls (median, 12.7 vs 14.4 g/dL; P = .01). Basophil levels were also significantly lower in cases than controls, with no differences for other leukocyte subsets. Cases had significantly higher urea, creatinine, protein, creatinine phosphokinase, and lactate dehydrogenase levels and lower bilirubin levels than controls. Cases and controls had similar frequencies of general, cutaneous, gastrointestinal, neurological, and cardiorespiratory signs. Conclusions: The first case-control study of apparently healthy SFV-infected Cameroonian hunters showed the presence of hematological abnormalities. A thorough clinical and laboratory workup is now needed to establish the medical relevance of these observations because more than half of cases had mild or moderate anemia. Clinical Trials Registration: NCT03225794.
Authors: Carmen Ledesma-Feliciano; Ryan M Troyer; Xin Zheng; Craig Miller; Rachel Cianciolo; Matteo Bordicchia; Nicholas Dannemiller; Roderick Gagne; Julia Beatty; Jessica Quimby; Martin Löchelt; Sue VandeWoude Journal: Viruses Date: 2019-07-19 Impact factor: 5.048
Authors: André F Santos; Marcelo A Soares; Cláudia P Muniz; Liliane T F Cavalcante; Dawn M Dudley; Alcides Pissinatti; David H O'Connor Journal: Microbiol Resour Announc Date: 2018-07-19
Authors: Liliane T F Cavalcante; Cláudia P Muniz; Hongwei Jia; Anderson M Augusto; Fernando Troccoli; Sheila de O Medeiros; Carlos G A Dias; William M Switzer; Marcelo A Soares; André F Santos Journal: Viruses Date: 2018-12-11 Impact factor: 5.048