Audrey J Gaskins1, Jaime E Hart2, Lidia Mínguez-Alarcón3, Jorge E Chavarro4, Francine Laden5, Brent A Coull6, Jennifer B Ford3, Irene Souter7, Russ Hauser8. 1. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Electronic address: agaskins@hsph.harvard.edu. 2. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA. 3. Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA. 4. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. 5. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. 6. Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA. 7. Vincent Obstetrics and Gynecology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. 8. Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Vincent Obstetrics and Gynecology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Abstract
BACKGROUND: Emerging data from animal and human studies suggest that traffic-related air pollution adversely affects early pregnancy outcomes; however evidence is limited. OBJECTIVE: We examined whether residential proximity to major roadways and traffic, as proxies for traffic-related air pollution, are associated with in vitro fertilization (IVF) outcomes. METHODS: This analysis included 423 women enrolled in the Environment and Reproductive Health (EARTH) Study, a prospective cohort study, who underwent 726 IVF cycles (2004-2017). Using geocoded residential addresses collected at study entry, we calculated the distance to nearest major roadway and the traffic density within a 100 m radius. IVF outcomes were abstracted from electronic medical records. We used multivariable generalized linear mixed models to evaluate the associations between residential proximity to major roadways and traffic density and IVF outcomes adjusting for maternal age, body mass index, race, education level, smoking status, and census tract median income. RESULTS: Closer residential proximity to major roadways was statistically significantly associated with lower probability of implantation and live birth following IVF. The adjusted percentage of IVF cycles resulting in live birth for women living ≥400 m from a major roadway was 46% (95% CI 36, 56%) compared to 33% (95% CI 26, 40%) for women living <50 m (p-for-comparison, 0.04). Of the intermediate outcomes, there were suggestive associations between living closer to major roadways and slightly higher estradiol trigger concentrations (p-trend = 0.16) and lower endometrial thickness (p-trend = 0.06). Near-residence traffic density was not associated with outcomes of IVF. CONCLUSION: Closer residential proximity to major roadways was related to reduced likelihood of live birth following IVF.
BACKGROUND: Emerging data from animal and human studies suggest that traffic-related air pollution adversely affects early pregnancy outcomes; however evidence is limited. OBJECTIVE: We examined whether residential proximity to major roadways and traffic, as proxies for traffic-related air pollution, are associated with in vitro fertilization (IVF) outcomes. METHODS: This analysis included 423 women enrolled in the Environment and Reproductive Health (EARTH) Study, a prospective cohort study, who underwent 726 IVF cycles (2004-2017). Using geocoded residential addresses collected at study entry, we calculated the distance to nearest major roadway and the traffic density within a 100 m radius. IVF outcomes were abstracted from electronic medical records. We used multivariable generalized linear mixed models to evaluate the associations between residential proximity to major roadways and traffic density and IVF outcomes adjusting for maternal age, body mass index, race, education level, smoking status, and census tract median income. RESULTS: Closer residential proximity to major roadways was statistically significantly associated with lower probability of implantation and live birth following IVF. The adjusted percentage of IVF cycles resulting in live birth for women living ≥400 m from a major roadway was 46% (95% CI 36, 56%) compared to 33% (95% CI 26, 40%) for women living <50 m (p-for-comparison, 0.04). Of the intermediate outcomes, there were suggestive associations between living closer to major roadways and slightly higher estradiol trigger concentrations (p-trend = 0.16) and lower endometrial thickness (p-trend = 0.06). Near-residence traffic density was not associated with outcomes of IVF. CONCLUSION: Closer residential proximity to major roadways was related to reduced likelihood of live birth following IVF.
Authors: M Brandes; J O M van der Steen; S B Bokdam; C J C M Hamilton; J P de Bruin; W L D M Nelen; J A M Kremer Journal: Hum Reprod Date: 2009-09-26 Impact factor: 6.918
Authors: David M Stieb; Li Chen; Perry Hystad; Bernardo S Beckerman; Michael Jerrett; Michael Tjepkema; Daniel L Crouse; D Walter Omariba; Paul A Peters; Aaron van Donkelaar; Randall V Martin; Richard T Burnett; Shiliang Liu; Marc Smith-Doiron; Rose M Dugandzic Journal: Environ Res Date: 2016-05-06 Impact factor: 6.498
Authors: Aurélien Wauters; Céline Dreyfuss; Stéphanie Pochet; Patrick Hendrick; Guy Berkenboom; Philippe van de Borne; Jean-François Argacha Journal: Hypertension Date: 2013-06-24 Impact factor: 10.190
Authors: Anelise Barth; Natália Brucker; Angela M Moro; Sabrina Nascimento; Gabriela Goethel; Caroline Souto; Rafael Fracasso; Elisa Sauer; Louise Altknecht; Bárbara da Costa; Marta Duarte; Camila B Menezes; Tiana Tasca; Marcelo D Arbo; Solange Cristina Garcia Journal: Environ Sci Pollut Res Int Date: 2016-10-08 Impact factor: 4.223
Authors: Sarah A Valentino; Anne Tarrade; Josiane Aioun; Eve Mourier; Christophe Richard; Michèle Dahirel; Delphine Rousseau-Ralliard; Natalie Fournier; Marie-Christine Aubrière; Marie-Sylvie Lallemand; Sylvaine Camous; Marine Guinot; Madia Charlier; Etienne Aujean; Hala Al Adhami; Paul H Fokkens; Lydiane Agier; John A Boere; Flemming R Cassee; Rémy Slama; Pascale Chavatte-Palmer Journal: Part Fibre Toxicol Date: 2016-07-26 Impact factor: 9.400
Authors: Jennifer Yland; Carmen Messerlian; Lidia Mínguez-Alarcón; Jennifer B Ford; Russ Hauser; Paige L Williams Journal: Hum Reprod Date: 2019-03-01 Impact factor: 6.918
Authors: Marianthi-Anna Kioumourtzoglou; Raanan Raz; Ander Wilson; Ronen Fluss; Ronit Nirel; David M Broday; Michele R Hacker; Thomas F McElrath; Itamar Grotto; Petros Koutrakis; Marc G Weisskopf Journal: Epidemiology Date: 2019-01 Impact factor: 4.822
Authors: Mary D Willis; Olivia R Orta; Collette Ncube; Amelia K Wesselink; Lan N Ðoàn; Kipruto Kirwa; Renée Boynton-Jarrett; Elizabeth E Hatch; Lauren A Wise Journal: JAMA Netw Open Date: 2022-06-01
Authors: Audrey J Gaskins; Kelvin C Fong; Yara Abu Awad; Qian Di; Lidia Mínguez-Alarcón; Jorge E Chavarro; Jennifer B Ford; Brent A Coull; Joel Schwartz; Itai Kloog; Irene Souter; Russ Hauser; Francine Laden Journal: Environ Health Perspect Date: 2019-07-03 Impact factor: 9.031
Authors: Amelia K Wesselink; Kipruto Kirwa; Elizabeth E Hatch; Perry Hystad; Adam A Szpiro; Joel D Kaufman; Jonathan I Levy; Ellen M Mikkelsen; Sabah M Quraishi; Kenneth J Rothman; Lauren A Wise Journal: Environ Epidemiol Date: 2020-11-11
Authors: Mary E Ingle; Lidia Mínguez-Alarcón; Courtney C Carignan; Heather M Stapleton; Paige L Williams; Jennifer B Ford; Molly B Moravek; Marie S O'Neill; Lu Wang; Russ Hauser; John D Meeker Journal: Environ Res Date: 2020-09-22 Impact factor: 6.498
Authors: Audrey J Gaskins; Ziyin Tang; Robert B Hood; Jennifer Ford; Joel D Schwartz; Dean P Jones; Francine Laden; Donghai Liang Journal: Environ Int Date: 2021-06-08 Impact factor: 9.621
Authors: Linda C Giudice; Erlidia F Llamas-Clark; Nathaniel DeNicola; Santosh Pandipati; Marya G Zlatnik; Ditas Cristina D Decena; Tracey J Woodruff; Jeanne A Conry Journal: Int J Gynaecol Obstet Date: 2021-10-25 Impact factor: 4.447