Literature DB >> 29605076

Future Approaches and Therapeutic Modalities for Acute Liver Failure.

Pavan Patel1, Nneoma Okoronkwo1, Nikolaos T Pyrsopoulos2.   

Abstract

The current gold standard for the management of acute liver failure is liver transplantation. However, because of organ shortages, other modalities of therapy are necessary as a possible bridge. This article discusses the current modalities as well as the future management of acute liver failure. Liver assist devices, hepatocyte transplantation, stem cell transplant, organogenesis, and repopulation of decellularized organs are discussed.
Copyright © 2018 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Acute liver failure; ELAD; HepatAssist; Hepatocyte transplant; Liver assist device; MARS; Organogenesis; Stem cell transplant

Mesh：

Year:  2018        PMID： 29605076     DOI： 10.1016/j.cld.2018.01.011

Source DB:  PubMed          Journal:  Clin Liver Dis        ISSN： 1089-3261            Impact factor:   6.126


  8 in total

1.  Sex-linked differences in the course of thioacetamide-induced acute liver failure in Lewis rats.

Authors:  E Koblihová; I Mrázová; Z Vaňourková; H Maxová; M Ryska; J Froněk
Journal:  Physiol Res       Date:  2020-09-09       Impact factor: 1.881

2.  Pharmacological stimulation of Wnt/beta-catenin signaling pathway attenuates the course of thioacetamide-induced acute liver failure.

Authors:  E Koblihová; I Mrázová; Z Vaňourková; H Maxová; S Kikerlová; Z Husková; M Ryska; J Froněk; Z Vernerová
Journal:  Physiol Res       Date:  2019-12-19       Impact factor: 1.881

Review 3.  The therapeutic potential of exosomes derived from different cell sources in liver diseases.

Authors:  Yun Pan; Wei-Feng Tan; Mu-Qing Yang; Ji-Yu Li; David A Geller
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2022-02-02       Impact factor: 4.052

4.  Selonsertib, a potential drug for liver failure therapy by rescuing the mitochondrial dysfunction of macrophage via ASK1-JNK-DRP1 pathway.

Authors:  Guohua Lou; Aichun Li; Yelei Cen; Qin Yang; Tianbo Zhang; Jinjin Qi; Zhi Chen; Yanning Liu
Journal:  Cell Biosci       Date:  2021-01-07       Impact factor: 7.133

5.  Human umbilical cord mesenchymal stem cells ameliorate acute liver failure by inhibiting apoptosis, inflammation and pyroptosis.

Authors:  Mengting Liu; Jing He; Shuo Zheng; Ke Zhang; Yu Ouyang; Yaqi Zhang; Changyong Li; Dongcheng Wu
Journal:  Ann Transl Med       Date:  2021-11

6.  UMSCs Attenuate LPS/D-GalN-induced Acute Liver Failure in Mice by Down-regulating the MyD88/NF-κB Pathway.

Authors:  Hailing Liao; Siying Du; Ting Jiang; Mengyao Zheng; Zhao Xiang; Jinhui Yang
Journal:  J Clin Transl Hepatol       Date:  2021-04-22

7.  SKLB023 protects mice against acute liver injury by inhibiting proinflammatory cytokine production in both T cells and macrophages.

Authors:  Jia Yu; Lili Liu; Huiming Zhang; Yating Wu; Heying Pei; Liang Ma; Anwen Xiong; Caifeng Xie
Journal:  RSC Adv       Date:  2018-09-27       Impact factor: 3.361

8.  Chrysophanol-8-O-glucoside protects mice against acute liver injury by inhibiting autophagy in hepatic stellate cells and inflammatory response in liver-resident macrophages.

Authors:  Tao Wang; Zhuo Lu; Xin-Hui Qu; Zi-Ying Xiong; Ya-Ting Wu; Yong Luo; Zi-Yu Zhang; Xiao-Jian Han; Cai-Feng Xie
Journal:  Front Pharmacol       Date:  2022-09-06       Impact factor: 5.988
  8 in total

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