| Literature DB >> 29604373 |
Zongmin Zhao1, Anvay Ukidve1, Anshuman Dasgupta1, Samir Mitragotri2.
Abstract
Immunomodulation, manipulation of the immune responses towards an antigen, is a promising strategy to treat cancer, infectious diseases, allergies, and autoimmune diseases, among others. Unique features of the skin including the presence of tissue-resident immune cells, ease of access and connectivity to other organs makes it a unique target organ for immunomodulation. In this review, we summarize advances in transdermal delivery of agents for modulating the immune responses for vaccination as well as tolerization. The biological foundation of skin-based immunomodulation and challenges in its implementation are described. Technological approaches aimed at enhancing the delivery of immunomodulatory therapeutics into skin are also discussed in this review. Progress made in the treatment of several specific diseases including cancer, infections and allergy are discussed. Finally, this review discusses some practical considerations and offers some recommendations for future studies in the field of transdermal immunomodulation.Entities:
Keywords: Autoimmune diseases; Cancer vaccine; Immune tolerance; Immunomodulation; Infectious diseases; Microneedle; Transdermal drug delivery; Vaccination
Mesh：
Year: 2018 PMID： 29604373 DOI： 10.1016/j.addr.2018.03.010
Source DB: PubMed Journal: Adv Drug Deliv Rev ISSN： 0169-409X Impact factor: 15.470