| Literature DB >> 29604247 |
Yongmei Yang1, Xiaohui Li2, Jie Du2, Youcong Yin2, Yuanjian Li3.
Abstract
It has been found that Helicobacter pylori （H. pylori）is not only the main cause of gastric cancer, but also closely related to its metastasis. E-cadherin cleavage induced by matrix metalloproteinases (MMPs) plays an important role in the tumor metastasis. In the present study, we investigated the role of microRNAs-MMPs-E-cadherin in migration and invasion of gastric cancer cells treated with H. pylori. The results showed that H. pylori induced migration and invasion of SGC-7901 cells with a down-regulation of E-cadherin expression, which were abolished by MMPs knock down, E-cadherin overexpression, mimics of miR128 and miR148a. MiR128/miR148a inhibitors restored MMP-3/MMP-7 expression, down-regulated E-cadherin level, and accelerated cellular migration and invasion. This study suggests that H. pylori induces migration and invasion of gastric cancer cells through reduction of E-cadherin function by activation of MMP-3, - 7. The present results also suggest that the activated MMPs/E-cadherin pathway is related with down-regulation of miR128/miR148a in the human gastric cancer cells infected with H. pylori.Entities:
Keywords: E-cadherin; Helicobacter pylori; Invasion; MMPs; MicroRNAs; Migration
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Year: 2018 PMID： 29604247 DOI： 10.1016/j.yexcr.2018.03.036
Source DB: PubMed Journal: Exp Cell Res ISSN： 0014-4827 Impact factor: 3.905