BACKGROUND: Blood pressure variability (BPV) has been shown to predict cardiovascular events. Within-visit BPV is the simplest and easiest measure of BPV, but previous studies have shown conflicts as to whether within-visit BPV correlates with target organ damage. We aimed to evaluate whether within-visit BPV correlates with B-type natriuretic peptide (BNP) in a general population. HYPOTHESIS: Within-visit BPV correlates with BNP in a general population. METHODS: This was a cross-sectional study that included 633 individuals, randomly selected, age 45 to 99 years, registered in the primary care program from an urban medium-sized town. Patients were scheduled for a single-day visit that consisted of clinical evaluation and laboratory tests. Three blood pressure (BP) readings, 1 minute apart, were done, and within-visit BPV was determined as the coefficient of variation (CV) of the 3 BP measures. Our main outcome was to correlate BNP and within-visit BPV. A multivariable model was estimated using a generalized linear model to evaluate the independent effects of different variables on BNP levels. RESULTS: The median age was 57 years. Median BNP was 16 pg/mL, and the median systolic and diastolic BP-CV were, respectively, 3.9% and 3.5%. There was a weak but positive correlation between BNP and both systolic BP-CV and diastolic BP-CV (r = 0.107 and P = 0.007 and r = 0.092 and P = 0.019, respectively). In multiple regression equation, systolic BP, diastolic BP-CV, body mass index, and estimated glomerular filtration rate were associated with BNP. CONCLUSIONS: In the present study, there was a positive, albeit weak, correlation between within-visit BPV and BNP. In addition, diastolic BPV was associated with BNP even after adjustment for multiple confounders.
BACKGROUND: Blood pressure variability (BPV) has been shown to predict cardiovascular events. Within-visit BPV is the simplest and easiest measure of BPV, but previous studies have shown conflicts as to whether within-visit BPV correlates with target organ damage. We aimed to evaluate whether within-visit BPV correlates with B-type natriuretic peptide (BNP) in a general population. HYPOTHESIS: Within-visit BPV correlates with BNP in a general population. METHODS: This was a cross-sectional study that included 633 individuals, randomly selected, age 45 to 99 years, registered in the primary care program from an urban medium-sized town. Patients were scheduled for a single-day visit that consisted of clinical evaluation and laboratory tests. Three blood pressure (BP) readings, 1 minute apart, were done, and within-visit BPV was determined as the coefficient of variation (CV) of the 3 BP measures. Our main outcome was to correlate BNP and within-visit BPV. A multivariable model was estimated using a generalized linear model to evaluate the independent effects of different variables on BNP levels. RESULTS: The median age was 57 years. Median BNP was 16 pg/mL, and the median systolic and diastolic BP-CV were, respectively, 3.9% and 3.5%. There was a weak but positive correlation between BNP and both systolic BP-CV and diastolic BP-CV (r = 0.107 and P = 0.007 and r = 0.092 and P = 0.019, respectively). In multiple regression equation, systolic BP, diastolic BP-CV, body mass index, and estimated glomerular filtration rate were associated with BNP. CONCLUSIONS: In the present study, there was a positive, albeit weak, correlation between within-visit BPV and BNP. In addition, diastolic BPV was associated with BNP even after adjustment for multiple confounders.
Authors: Tan Lai Zhou; Abraham A Kroon; Koen D Reesink; Miranda T Schram; Annemarie Koster; Nicolaas C Schaper; Pieter C Dagnelie; Carla J H van der Kallen; Simone J S Sep; Coen D A Stehouwer; Ronald M A Henry Journal: J Hypertens Date: 2018-02 Impact factor: 4.844
Authors: Ana Beatriz Rodrigues; Ronaldo Altenburg Gismondi; Antonio Lagoeiro; Angela Mendes Cecilio; Delvo Vasques; Rafael Arita; Thabata Folegatti; Maria Luiza Rosa Journal: Clin Cardiol Date: 2018-05-10 Impact factor: 2.882
Authors: Antonio Lagoeiro Jorge; Maria Luiza G Rosa; Wolney A Martins; Dayse Mary S Correia; Luiz Claudio M Fernandes; Jean A Costa; Samuel D Moscavitch; Bruno Afonso L Jorge; Evandro T Mesquita Journal: J Card Fail Date: 2015-11-04 Impact factor: 5.712
Authors: Sarah L Stevens; Sally Wood; Constantinos Koshiaris; Kathryn Law; Paul Glasziou; Richard J Stevens; Richard J McManus Journal: BMJ Date: 2016-08-09
Authors: Ana Beatriz Rodrigues; Ronaldo Altenburg Gismondi; Antonio Lagoeiro; Angela Mendes Cecilio; Delvo Vasques; Rafael Arita; Thabata Folegatti; Maria Luiza Rosa Journal: Clin Cardiol Date: 2018-05-10 Impact factor: 2.882