Junga Lee1. 1. Author Affiliation: Graduate School of Sport Science, Kyung Hee University, Republic of Korea.
Abstract
BACKGROUND: There are conflicting data on the association between physical activity (PA) intensity and amount and prognosis of breast cancer. It is unknown whether increasing or decreasing PA is associated with all-cause mortality. OBJECTIVE: The purpose of this study was to estimate the associations between PA and the risk of mortality. METHODS: MEDLINE and EMBASE were used to find eligible studies published from January 1970 to March 2017 for this meta-analysis. We included 24 studies, with a total of 144 224 patients and follow-up periods ranging from 1.9 to 12.7 years. We categorized the amount of PA as low (<300 min/wk), moderate (300-500 min/wk), and high (>500 min/wk). RESULTS: We found that high amounts of PA had an inverse relationship with breast-cancer-specific mortality and all-cause morality. Patients who decreased PA after diagnosis showed poorer all-cause mortality, whereas patients who increased PA postdiagnosis had a favorable association with all-cause mortality. Last, patients who met PA guidelines after diagnosis had a lower breast-cancer-specific mortality and all-cause mortality. CONCLUSION: Physical activity may play a pivotal role in reducing the risk of death. Getting at least 300 min/wk of moderate-intensity PA will help improve the risk of breast cancer death. IMPLICATIONS FOR PRACTICE: Participating in PA is an essential factor in breast cancer care that extends throughout the life span of cancer survivors. Higher levels of PA than current PA guidelines should be recommended to cancer patients.
BACKGROUND: There are conflicting data on the association between physical activity (PA) intensity and amount and prognosis of breast cancer. It is unknown whether increasing or decreasing PA is associated with all-cause mortality. OBJECTIVE: The purpose of this study was to estimate the associations between PA and the risk of mortality. METHODS: MEDLINE and EMBASE were used to find eligible studies published from January 1970 to March 2017 for this meta-analysis. We included 24 studies, with a total of 144 224 patients and follow-up periods ranging from 1.9 to 12.7 years. We categorized the amount of PA as low (<300 min/wk), moderate (300-500 min/wk), and high (>500 min/wk). RESULTS: We found that high amounts of PA had an inverse relationship with breast-cancer-specific mortality and all-cause morality. Patients who decreased PA after diagnosis showed poorer all-cause mortality, whereas patients who increased PA postdiagnosis had a favorable association with all-cause mortality. Last, patients who met PA guidelines after diagnosis had a lower breast-cancer-specific mortality and all-cause mortality. CONCLUSION: Physical activity may play a pivotal role in reducing the risk of death. Getting at least 300 min/wk of moderate-intensity PA will help improve the risk of breast cancer death. IMPLICATIONS FOR PRACTICE: Participating in PA is an essential factor in breast cancer care that extends throughout the life span of cancer survivors. Higher levels of PA than current PA guidelines should be recommended to cancerpatients.
Authors: Rikki A Cannioto; Alan Hutson; Shruti Dighe; William McCann; Susan E McCann; Gary R Zirpoli; William Barlow; Kara M Kelly; Carol A DeNysschen; Dawn L Hershman; Joseph M Unger; Halle C F Moore; James A Stewart; Claudine Isaacs; Timothy J Hobday; Muhammad Salim; Gabriel N Hortobagyi; Julie R Gralow; Kathy S Albain; G Thomas Budd; Christine B Ambrosone Journal: J Natl Cancer Inst Date: 2021-01-04 Impact factor: 13.506
Authors: Daniel Tough; Jonathan Robinson; Steven Gowling; Peter Raby; John Dixon; Samantha L Harrison Journal: BMC Cancer Date: 2018-11-21 Impact factor: 4.430
Authors: Matteo Floris; Giovanna Pira; Paolo Castiglia; Maria Laura Idda; Maristella Steri; Maria Rosaria De Miglio; Andrea Piana; Andrea Cossu; Antonio Azara; Caterina Arru; Giovanna Deiana; Carlo Putzu; Valeria Sanna; Ciriaco Carru; Antonello Serra; Marco Bisail; Maria Rosaria Muroni Journal: Oncol Lett Date: 2022-08-08 Impact factor: 3.111