Ying-Ming Chiu1,2, Chung-Lin Tsai3,4, Jung-Ta Kao3,5, Chin-Tung Hsieh6, Dong-Chen Shieh2, Yi-Ju Lee7, Gregory J Tsay8,9, Ken-Sheng Cheng10, Yi-Ying Wu11. 1. Division of Allergy, Immunology & Rheumatology, Changhua Christian Hospital, Changhua, Taiwan, R.O.C. 2. Department of Nursing, College of Medicine & Nursing, Hungkuang University, Taichung, Taiwan, R.O.C. 3. Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan, R.O.C. 4. Division of Cardiovascular Surgery, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C. 5. Department of Internal Medicine, School of Medicine, China Medical University Hospital and China Medical University, Taichung, Taiwan, R.O.C. 6. Department of Pediatrics, Lotung Poh-Ai Hospital, I-Lan, Taiwan, R.O.C. 7. Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan, R.O.C. 8. Division of Immunology and Rheumatology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan, R.O.C. 9. School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan, R.O.C. 10. Department of Internal Medicine, Division of Hepato-Gastroenterology, China Medical University Hospital, Taichung, Taiwan, R.O.C. 11. Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan, R.O.C. yyw@mail.cmu.edu.tw.
Abstract
BACKGROUND/AIM: The programmed death 1 (PD-1) receptor and its ligand (PD-L1) play pivotal roles in regulating host immune responses. However, the inhibitory effects of this pathway on the function of tumor infiltrating T lymphocytes in gastric adenocarcinoma patients are not well-defined. MATERIALS AND METHODS: We characterized the expression of PD-1 and PD-L1 in peripheral blood and tumor infiltrating cells and analyzed the association between PD-1/PD-L1 expression and disease progression in a cohort of 60 patients with Helicobacter pylori infection, including 18 with gastric adenocarcinoma, 23 with gastritis, and 19 asymptomatic controls. RESULTS: Relative to controls, the expression of PD-1 on peripheral blood and tumor infiltrating T cells increased with disease progression. In vitro, T cells induced PD-L1 expression on primary gastric adenocarcinoma epithelial cells in an IFN-γ-dependent manner, which in turn promoted T cells apoptosis. Blocking of PD-L1 reversed this effect. CONCLUSION: This study provides evidence for a new therapeutic target in gastric adenocarcinoma patients. Copyright
BACKGROUND/AIM: The programmed death 1 (PD-1) receptor and its ligand (PD-L1) play pivotal roles in regulating host immune responses. However, the inhibitory effects of this pathway on the function of tumor infiltrating T lymphocytes in gastric adenocarcinomapatients are not well-defined. MATERIALS AND METHODS: We characterized the expression of PD-1 and PD-L1 in peripheral blood and tumor infiltrating cells and analyzed the association between PD-1/PD-L1 expression and disease progression in a cohort of 60 patients with Helicobacter pylori infection, including 18 with gastric adenocarcinoma, 23 with gastritis, and 19 asymptomatic controls. RESULTS: Relative to controls, the expression of PD-1 on peripheral blood and tumor infiltrating T cells increased with disease progression. In vitro, T cells induced PD-L1 expression on primary gastric adenocarcinoma epithelial cells in an IFN-γ-dependent manner, which in turn promoted T cells apoptosis. Blocking of PD-L1 reversed this effect. CONCLUSION: This study provides evidence for a new therapeutic target in gastric adenocarcinomapatients. Copyright
Authors: Nathan Ryan; Kelvin Anderson; Greta Volpedo; Omar Hamza; Sanjay Varikuti; Abhay R Satoskar; Steve Oghumu Journal: Int J Cancer Date: 2019-11-29 Impact factor: 7.396
Authors: Leila Abdelhamid; Xavier Cabana-Puig; Qinghui Mu; Maryam Moarefian; Brianna Swartwout; Kristin Eden; Prerna Das; Ryan P Seguin; Libin Xu; Sarah Lowen; Mital Lavani; Terry C Hrubec; Caroline N Jones; Xin M Luo Journal: Front Immunol Date: 2020-10-21 Impact factor: 7.561